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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemotherapy for advanced head and neck cancer with the combination adriamycin, cyclophosphamide, and cis-diamminedichloroplatinum (II): preliminary assessment of a one-day vs. three-day drug regimen.

Fourteen patients with advanced head and neck carcinomas received a monthly intravenous regimen of Adriamycin, 40 mg/m2, day 1; cyclophosphamide, 400 mg/m2, day 3; and cis-diamminedichloroplatinum, 20 mg/m2/1 hour, days 1-3 (CAP-3). A regression rate of only 7% (0/12 squamous cell carcinomas; 1/2 adenocarcinomas) and a median survival of five months for all patients was accompanied by considerable gastrointestinal toxicity. These results strikingly diverge from a prior study that achieved a 64% (16/25) regression rate using comparable doses of each agent but was administered by rapid infusion on one day each month ( CAP-1). Admittedly, the relatively impaired performance scores of the CAP-3 participants may have had some impact on these discouraging results. On the other hand, the maximum therapeutic efficacy of the combination Adriamycin, cyclophosphamide, and cis-platinum may well depend upon subtle interactions of cell cycle kinetics and dosage and schedule of each agent.[1]

References

  1. Chemotherapy for advanced head and neck cancer with the combination adriamycin, cyclophosphamide, and cis-diamminedichloroplatinum (II): preliminary assessment of a one-day vs. three-day drug regimen. Creagan, E.T., Fleming, T.R., Edmonson, J.H., Ingle, J.N., Woods, J.E. Cancer (1981) [Pubmed]
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