Gene Review:
SERPINB9 - serpin peptidase inhibitor, clade B...
Homo sapiens
Synonyms:
CAP-3, CAP3, Cytoplasmic antiproteinase 3, PI-9, PI9, ...
- The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation. Rowshani, A.T., Strik, M.C., Molenaar, R., Yong, S.L., Wolbink, A.M., Bemelman, F.J., Hack, C.E., Ten Berge, I.J. J. Infect. Dis. (2005)
- Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma. ten Berge, R.L., Meijer, C.J., Dukers, D.F., Kummer, J.A., Bladergroen, B.A., Vos, W., Hack, C.E., Ossenkoppele, G.J., Oudejans, J.J. Blood (2002)
- Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors. Sprecher, C.A., Morgenstern, K.A., Mathewes, S., Dahlen, J.R., Schrader, S.K., Foster, D.C., Kisiel, W. J. Biol. Chem. (1995)
- Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. van Houdt, I.S., Oudejans, J.J., van den Eertwegh, A.J., Baars, A., Vos, W., Bladergroen, B.A., Rimoldi, D., Muris, J.J., Hooijberg, E., Gundy, C.M., Meijer, C.J., Kummer, J.A. Clin. Cancer Res. (2005)
- The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. Young, J.L., Sukhova, G.K., Foster, D., Kisiel, W., Libby, P., Schönbeck, U. J. Exp. Med. (2000)
- Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2. Godal, R., Keilholz, U., Uharek, L., Letsch, A., Asemissen, A.M., Busse, A., Na, I.K., Thiel, E., Scheibenbogen, C. Blood (2006)
- The C-terminal 26-residue peptide of serpin A1 is an inhibitor of HIV-1. Congote, L.F. Biochem. Biophys. Res. Commun. (2006)
- Chemotherapy for advanced head and neck cancer with the combination adriamycin, cyclophosphamide, and cis-diamminedichloroplatinum (II): preliminary assessment of a one-day vs. three-day drug regimen. Creagan, E.T., Fleming, T.R., Edmonson, J.H., Ingle, J.N., Woods, J.E. Cancer (1981)
- A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes. Sun, J., Stephens, R., Mirza, G., Kanai, H., Ragoussis, J., Bird, P.I. Cytogenet. Cell Genet. (1998)
- Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Bird, C.H., Blink, E.J., Hirst, C.E., Buzza, M.S., Steele, P.M., Sun, J., Jans, D.A., Bird, P.I. Mol. Cell. Biol. (2001)
- Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9. Dahlen, J.R., Foster, D.C., Kisiel, W. Biochim. Biophys. Acta (1999)
- Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells. Kanamori, H., Krieg, S., Mao, C., Di Pippo, V.A., Wang, S., Zajchowski, D.A., Shapiro, D.J. J. Biol. Chem. (2000)
- The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency. Hirst, C.E., Buzza, M.S., Bird, C.H., Warren, H.S., Cameron, P.U., Zhang, M., Ashton-Rickardt, P.G., Bird, P.I. J. Immunol. (2003)
- A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. Sun, J., Bird, C.H., Sutton, V., McDonald, L., Coughlin, P.B., De Jong, T.A., Trapani, J.A., Bird, P.I. J. Biol. Chem. (1996)
- The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation. Golks, A., Brenner, D., Schmitz, I., Watzl, C., Krueger, A., Krammer, P.H., Lavrik, I.N. Cell Death Differ. (2006)