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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom.

Black widow spider venom (BWSV) elicited a prolonged tonic contraction of guinea-pig ileum which abolished the nicotine-induced contraction; however, the subsequent acetylcholine stimulation was found to be unchanged. These findings indicate a depletion of nerve terminal transmitters caused by BWSV without a disruption of the muscle contractile mechanism. Following the BWSV-induced contraction, the stimulation to 5-hydroxytryptamine (5-HT) was found to be abolished. This abolishment indicates a mediation of 5-HT-induced smooth muscle contraction in the nerve rather than the muscle.[1]

References

  1. Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom. Primor, N. Eur. J. Pharmacol. (1980) [Pubmed]
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