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MeSH Review

Black Widow Spider

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High impact information on Black Widow Spider


Anatomical context of Black Widow Spider


Associations of Black Widow Spider with chemical compounds


Gene context of Black Widow Spider

  • Regeneration of soleus motor nerve terminals after focal destruction by black widow spider venom (BWSV) or its active factor alpha-latrotoxin (LTx) was compared in young and old CBF-1 mice [15].
  • Alpha-latrotoxin, the poison of the black widow spider, binds at a 54 kDa aminoterminal fragment of HC110R [16].
  • Some samples of latrotoxin purified from the black widow spider venom contain two components: alpha-latrotoxin (M(r) approximately 130,000) and a low mol. wt protein with M(r) about 8000 [17].
  • Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones [18].


  1. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Südhof, T.C. Annu. Rev. Neurosci. (2001) [Pubmed]
  2. Isolation and properties of the alpha-latrotoxin receptor. Petrenko, A.G., Kovalenko, V.A., Shamotienko, O.G., Surkova, I.N., Tarasyuk, T.A., Ushkaryov YuA, n.u.l.l., Grishin, E.V. EMBO J. (1990) [Pubmed]
  3. Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP. Yoshihara, M., Ueda, A., Zhang, D., Deitcher, D.L., Schwarz, T.L., Kidokoro, Y. J. Neurosci. (1999) [Pubmed]
  4. Effects of botulinum toxin on neuromuscular transmission in the rat. Cull-Candy, S.G., Lundh, H., Thesleff, S. J. Physiol. (Lond.) (1976) [Pubmed]
  5. Incorporation of vesicular antigens into the presynaptic membrane during exocytosis at the frog neuromuscular junction: a light and electron microscopy immunochemical study. Robitaille, R., Tremblay, J.P. Neuroscience (1987) [Pubmed]
  6. The release of acetylcholine elicited by extracts of black widow spider glands: studies using rat superior cervical ganglia and inhibitors of electrically stimulated release. Pumplin, D.W., McClure, W.O. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  7. Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands. Pardal, J.F., Granata, A.R., Barrio, A., Gimeno, A.L. Naunyn Schmiedebergs Arch. Pharmacol. (1980) [Pubmed]
  8. Inhibition of 5-hydroxytryptamine contraction of guinea-pig smooth muscle treated with black widow spider venom. Primor, N. Eur. J. Pharmacol. (1980) [Pubmed]
  9. The effect of the purified major protein factor (alpha-latrotoxin) of black widow spider venom on the release of acetylcholine and norepinephrine from mouse cerebral cortex slices. Tzeng, M.C., Siekevitz, P. Brain Res. (1978) [Pubmed]
  10. alpha Latrotoxin of black widow spider venom binds to a specific receptor coupled to phosphoinositide breakdown in PC12 cells. Vicentini, L.M., Meldolesi, J. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  11. alpha Latrotoxin of the black widow spider venom opens a small, non-closing cation channel. Wanke, E., Ferroni, A., Gattanini, P., Meldolesi, J. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  12. A comparison of calcium gluconate and methocarbamol (Robaxin) in the treatment of Latrodectism (black widow spider envenomation). Key, G.F. Am. J. Trop. Med. Hyg. (1981) [Pubmed]
  13. Preliminary report: experience with the use of dantrolene sodium in the treatment of bites by the black widow spider Latrodectus hesperus. Ryan, P.J. J. Toxicol. Clin. Toxicol. (1983) [Pubmed]
  14. 4-aminoquinoline-induced 'giant' miniature endplate potentials at mammalian neuromuscular junctions. Molgó, J., Thesleff, S. Proc. R. Soc. Lond., B, Biol. Sci. (1982) [Pubmed]
  15. Motor nerve terminal restoration after focal destruction in young and old mice. Robbins, N., Kuchynski, M., Polak, J., Grasso, A. Int. J. Dev. Neurosci. (1990) [Pubmed]
  16. Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Harder, A., Schmitt-Wrede, H.P., Krücken, J., Marinovski, P., Wunderlich, F., Willson, J., Amliwala, K., Holden-Dye, L., Walker, R. Int. J. Antimicrob. Agents (2003) [Pubmed]
  17. Structure of the low molecular weight protein copurified with alpha-latrotoxin. Kiyatkin, N., Dulubova, I., Chekhovskaya, I., Lipkin, A., Grishin, E. Toxicon (1992) [Pubmed]
  18. Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Holz, G.G., Habener, J.F. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
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