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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Brain cholinesterases activity in healthy cattle, swine, and sheep and in cattle and sheep exposed to cholinesterase-inhibiting insecticides.

Cholinesterase activity of the cerebrum, brain stem, and cerebellum was measured in cattle, swine, and sheep. Mean activities of the individual brain parts were expressed as micromoles of acetylthiocholine iodide hydrolyzed per minute per gram of brain. Cerebrum values were 3.01, 3.88, and 3.32; brain stem values were 3.42, 4.48, and 3.93; and cerebellum values were 2.36, 2.89, and 6.77 for cattle, swine, and sheep, respectively. The average activity of the 3 brain portions from cattle, swine, and sheep was 2.93, 3.75, and 4.67, respectively. Cholinesterase activity was stable for several days at 25 C and under refrigeration or freezing conditions for longer periods. Cattle and sheep poisoned with organophosphate or carbamate insecticides had cholinesterase depression ranging from near 50% to 80%.[1]


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