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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation.

N-Nitrosopyrrolidine (NPyrr) and N-nitrosopiperidine (NPip) are carcinogenic and mutagenic cyclic nitrosamines. Their biotransformation by rat liver post-mitochondrial fraction into 1,4-butanediol and 1,5-pentanediol, respectively, is evaluated by determining these ultimate metabolites with a sensitive and suitable method. Their mutagenic activity towards the Salmonella typhimurium strain TA 1530 was simultaneously observed. A relationship exists between their metabolism and their mutagenicity. alpha-Hydroxylation is probably the critical metabolic metabolism of cyclic nitrosamines.[1]

References

  1. Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation. Gilbert, P.J., Rollmann, B., Rondelet, J., Mercier, M., Poncelet, F. Toxicology (1981) [Pubmed]
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