The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Sucol B     butane-1,4-diol

Synonyms: Agrisynth B1D, AGN-PC-0099XE, CHEMBL171623, DIOL 14B, Poly THF, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Butyl Group

  • This work indicates that the relatively high native concentration of + (large KW), which has commonly been thought to lead to the occurrence of acid-catalyzed reactions in HTW without added catalyst, does not explain the dehydration of 1,4-butanediol in HTW without catalyst [1].
  • BACKGROUND: Toxicity of 1,4-butanediol, an industrial solvent and a substance of abuse, is still misunderstood and not well documented [2].
  • 1,4-Butanediol (1,4-BD), a prodrug converted in vivo to gamma-hydroxybutyric acid by alcohol dehydrogenase, has resulted in life-threatening overdoses and deaths [3].
  • We conclude that GHB, GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO [4].
  • In transient MCAO, the mean volume of infarction for control rats was 464.4 +/- 17.9 versus 273.6 +/- 53.1, 233.3 +/- 44.7, and 275.4 +/- 39.9 for rats treated with 1,4-BD (P < 0.05), GBL (P < 0.05), and GHB (P < 0.05), respectively [4].

Psychiatry related information on Butyl Group


High impact information on Butyl Group


Chemical compound and disease context of Butyl Group


Biological context of Butyl Group


Anatomical context of Butyl Group


Associations of Butyl Group with other chemical compounds


Gene context of Butyl Group

  • METHODS: We investigated this possibility by flow cytometric analysis of membrane glycoproteins (GPs) Ib and IIb/IIIa and the activation markers CD62P and CD63 in platelet concentrates (PCs) prepared from whole blood that was held for either 6 h without cooling plates (n = 20) or for 24 h on cooling plates of 1,4-butanediol (n = 20) [24].
  • A related increase in tissue 1,4-BD concentration supported the hypothesis of an in vivo competition of the two substances for alcohol dehydrogenase [25].
  • Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1-2 h later) [26].
  • The mixed macrodiols were reacted with 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO) chain extender [27].
  • CD-1 mice were overdosed with 1,4-BD, 600 mg/kg i.p. Mice then received 4-MP, 25 mg/kg i.p., or control injections after 1 min, 5 min, and symptom appearance [3].

Analytical, diagnostic and therapeutic context of Butyl Group

  • Poly(ether ester amide) (PEEA) copolymers based on poly(ethylene glycol) (PEG), 1,4-butanediol and dimethyl-7,12-diaza-6,13-dione-1,18-octadecanedioate were evaluated as scaffold materials for tissue engineering [28].
  • Pretreatment with 4-MP also increased the TD(50) of 1,4-BD for the rotarod test from 163 mg/kg (95% CI, 136-196 mg/kg) in control mice to 4,900 mg/kg (95% CI, 4,812-4,989 mg/kg) in pretreated mice [29].
  • A severe withdrawal syndrome from GHB, 1,4-BD and GBL has been increasingly documented over the last years, necessitating the development of a reliable animal model for investigations of potential therapeutic approaches [30].
  • Laboratory diagnosis of 1,4-BD and GHB overdose by routine urine organic acid analysis [31].
  • Two organic solvents, phenol and 1,4-butanediol, were used as additives to facilitate the crystallization of free rTxln-1 [32].


  1. Kinetics and mechanism of tetrahydrofuran synthesis via 1,4-butanediol dehydration in high-temperature water. Hunter, S.E., Ehrenberger, C.E., Savage, P.E. J. Org. Chem. (2006) [Pubmed]
  2. Treatment of a 1,4-butanediol poisoning with fomepizole. Mégarbane, B., Fompeydie, D., Garnier, R., Baud, F.J. J. Toxicol. Clin. Toxicol. (2002) [Pubmed]
  3. 4-methylpyrazole decreases 1,4-butanediol toxicity by blocking its in vivo biotransformation to gamma-hydroxybutyric acid. Quang, L.S., Desai, M.C., Shannon, M.W., Woolf, A.D., Maher, T.J. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  4. {gamma}-Hydroxybutyrate (GHB), {gamma}-Butyrolactone (GBL), and 1,4-Butanediol (1,4-BD) Reduce the Volume of Cerebral Infarction in Rodent Transient Middle Cerebral Artery Occlusion. Sadasivan, S., Maher, T.J., Quang, L.S. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  5. Comparison of the actions of gamma-butyrolactone and 1,4-butanediol in Swiss-Webster mice. de Fiebre, C.M., de Fiebre, N.E., Coleman, S.L., Forster, M.J. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  6. Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase. Struys, E.A., Verhoeven, N.M., Jansen, E.E., Ten Brink, H.J., Gupta, M., Burlingame, T.G., Quang, L.S., Maher, T., Rinaldo, P., Snead, O.C., Goodwin, A.K., Weerts, E.M., Brown, P.R., Murphy, T.C., Picklo, M.J., Jakobs, C., Gibson, K.M. Metab. Clin. Exp. (2006) [Pubmed]
  7. Clinical Pharmacology of 1,4-Butanediol and Gamma-hydroxybutyrate After Oral 1,4-Butanediol Administration to Healthy Volunteers. Thai, D., Dyer, J.E., Jacob, P., Haller, C.A. Clin. Pharmacol. Ther. (2007) [Pubmed]
  8. Macroporous polyacrylamide-based monolithic column with immobilized pH gradient for protein analysis. Zhu, G., Yuan, H., Zhao, P., Zhang, L., Liang, Z., Zhang, W., Zhang, Y. Electrophoresis (2006) [Pubmed]
  9. First preparation of spacer-linked cyclic neooligoaminodeoxysaccharides. Chen, G.W., Kirschning, A. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  10. Evaluation of a kinetic method for prostatic acid phosphatase with use of self-indicating substrate, 2,6-dichloro-4-nitrophenyl phosphate. Valcour, A.A., Bowers, G.N., McComb, R.B. Clin. Chem. (1989) [Pubmed]
  11. Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats. Carter, L.P., Koek, W., France, C.P. Eur. J. Neurosci. (2006) [Pubmed]
  12. Enzyme and receptor antagonists for preventing toxicity from the gamma-hydroxybutyric acid precursor 1,4-butanediol in CD-1 mice. Quang, L.S., Desai, M.C., Kraner, J.C., Shannon, M.W., Woolf, A.D., Maher, T.J. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  13. Kinetic study of the alpha-chymotrypsin-catalyzed hydrolysis and synthesis of a peptide bond in a monophasic aqueous/organic reaction medium. Deschrevel, B., Vincent, J.C., Thellier, M. Arch. Biochem. Biophys. (1993) [Pubmed]
  14. Interaction between 1,4-butanediol and ethanol on operant responding and the cardiovascular system. Gerak, L.R., Hicks, A.R., Winsauer, P.J., Varner, K.J. Eur. J. Pharmacol. (2004) [Pubmed]
  15. Thermodynamic parameters monitoring the equilibrium shift of enzyme-catalyzed hydrolysis/synthesis reactions in favor of synthesis in mixtures of water and organic solvent. Deschrevel, B., Vincent, J.C., Ripoll, C., Thellier, M. Biotechnol. Bioeng. (2003) [Pubmed]
  16. Mutagenicity and alpha-hydroxylation of N-nitrosopyrrolidine and N-nitrosopiperidine: a possible correlation. Gilbert, P.J., Rollmann, B., Rondelet, J., Mercier, M., Poncelet, F. Toxicology (1981) [Pubmed]
  17. Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid. Carai, M.A., Colombo, G., Reali, R., Serra, S., Mocci, I., Castelli, M.P., Cignarella, G., Gessa, G.L. Eur. J. Pharmacol. (2002) [Pubmed]
  18. A simple GC method for determination of cryoprotector diols 1,4-butanediol or 2,3-butanediol in isolated rat hepatocytes. Almada, L., Guibert, E.E., Rodriguez, J.V. Cryo letters. (2002) [Pubmed]
  19. Distribution of pyrimidine synthetic enzymes in the rat testis. Nishikawara, M.T., Leung, F.Y. Arch. Androl. (1979) [Pubmed]
  20. 1,4 Butanediol, gamma-hydroxybutyric acid and ethanol: relationships and interactions. Poldrugo, F., Snead, O.C. Neuropharmacology (1984) [Pubmed]
  21. Studies on the relation of gamma-hydroxybutyric acid (GHB) to gamma-aminobutyric acid (GABA). Evidence that GABA is not the sole source for GHB in rat brain. Snead, O.C., Liu, C.C., Bearden, L.J. Biochem. Pharmacol. (1982) [Pubmed]
  22. Optimization of binary porogen solvent composition for preparation of butyl methacrylate monoliths in capillary liquid chromatography. Grafnetter, J., Coufal, P., Tesarová, E., Suchánková, J., Bosáková, Z., Sevcík, J. Journal of chromatography. A. (2004) [Pubmed]
  23. Air-stable titanium alkoxide based metal-organic framework as an initiator for ring-opening polymerization of cyclic esters. Chuck, C.J., Davidson, M.G., Jones, M.D., Kociok-Köhn, G., Lunn, M.D., Wu, S. Inorganic chemistry. (2006) [Pubmed]
  24. Prolonged holding of whole blood at 22 degrees C does not increase activation in platelet concentrates. Sanz, C., Pereira, A., Faúndez, A.I., Ordinas, A. Vox Sang. (1997) [Pubmed]
  25. Ethanol potentiates the toxic effects of 1,4-butanediol. Poldrugo, F., Barker, S., Basa, M., Mallardi, F., Snead, O.C. Alcohol. Clin. Exp. Res. (1985) [Pubmed]
  26. Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo. Satta, R., Dimitrijevic, N., Manev, H. Eur. J. Pharmacol. (2003) [Pubmed]
  27. Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: biostability. Martin, D.J., Warren, L.A., Gunatillake, P.A., McCarthy, S.J., Meijs, G.F., Schindhelm, K. Biomaterials (2000) [Pubmed]
  28. Poly(ether ester amide)s for tissue engineering. Deschamps, A.A., van Apeldoorn, A.A., de Bruijn, J.D., Grijpma, D.W., Feijen, J. Biomaterials (2003) [Pubmed]
  29. Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. Quang, L.S., Shannon, M.W., Woolf, A.D., Desai, M.C., Maher, T.J. Life Sci. (2002) [Pubmed]
  30. Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats. Carai, M.A., Quang, L.S., Atzeri, S., Lobina, C., Maccioni, P., Orrù, A., Gessa, G.L., Maher, T.J., Colombo, G. Brain Res. Brain Res. Protoc. (2005) [Pubmed]
  31. Laboratory diagnosis of 1,4-BD and GHB overdose by routine urine organic acid analysis. Quang, L.S., Levy, H.L., Law, T., Desai, M.C., Maher, T.J., Boyer, E.W., Shannon, M.W., Woolf, A.D. Clinical toxicology (Philadelphia, Pa.) (2005) [Pubmed]
  32. Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Millers, E.K., Masci, P.P., Lavin, M.F., de Jersey, J., Guddat, L.W. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
WikiGenes - Universities