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Chemical Compound Review

N-NITROSOPYRROLIDINE     1-nitrosopyrrolidine

Synonyms: NPYR, No-pyr, N-PYR, N-N-PYR, CCRIS 478, ...
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Disease relevance of N-NITROSOPYRROLIDINE


High impact information on N-NITROSOPYRROLIDINE


Chemical compound and disease context of N-NITROSOPYRROLIDINE


Biological context of N-NITROSOPYRROLIDINE


Anatomical context of N-NITROSOPYRROLIDINE


Associations of N-NITROSOPYRROLIDINE with other chemical compounds




Analytical, diagnostic and therapeutic context of N-NITROSOPYRROLIDINE


  1. Induction of liver tumors in F344 rats by crotonaldehyde. Chung, F.L., Tanaka, T., Hecht, S.S. Cancer Res. (1986) [Pubmed]
  2. The effect of pyrazole, phenobarbital, ethanol and 3-methylcholanthrene pretreatment on the in vivo and in vitro genotoxicity of N-nitrosopyrrolidine. Gold, B., Brunk, G. Carcinogenesis (1988) [Pubmed]
  3. The role of DNA-repair processes in N-nitrosopyrrolidine-induced mutagenesis. Alldrick, A.J., Cottrell, R.C., Rowland, I.R., Gangolli, S.D. Carcinogenesis (1985) [Pubmed]
  4. Induced mutations in M13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA irradiation. Arimoto-Kobayashi, S., Inada, N., Anma, N., Shimada, H., Hayatsu, H. Environ. Mol. Mutagen. (1999) [Pubmed]
  5. Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. Miyata, Y., Fukushima, S., Hirose, M., Masui, T., Ito, N. Jpn. J. Cancer Res. (1985) [Pubmed]
  6. Greater effectiveness of hepatocyte and liver S9 preparations from hamsters than rat preparations in activating N-nitroso compounds to metabolites mutagenic to Salmonella. Raineri, R., Poiley, J.A., Andrews, A.W., Pienta, R.J., Lijinsky, W. J. Natl. Cancer Inst. (1981) [Pubmed]
  7. Mutagenicity of five cyclic N-nitrosamines: assay with Salmonella typhimurium. Stoltz, D.R., Sen, N.P. J. Natl. Cancer Inst. (1977) [Pubmed]
  8. Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi. Harris, C.C., Autrup, H., Stoner, G.D., McDowell, E.M., Trump, B.F., Schafer, P. J. Natl. Cancer Inst. (1977) [Pubmed]
  9. Detection of exocyclic guanine adducts in hydrolysates of hepatic DNA of rats treated with N-nitrosopyrrolidine and in calf thymus DNA reacted with alpha-acetoxy-N-nitrosopyrrolidine. Chung, F.L., Wang, M.Y., Hecht, S.S. Cancer Res. (1989) [Pubmed]
  10. The pH-dependent response of Salmonella typhimurium TA100 to mutagenic N-nitrosamines. Negishi, T., Hayatsu, H. Mutat. Res. (1980) [Pubmed]
  11. Mutagenesis by N-nitroso compounds in Salmonella typhimurium TA102 and TA104: evidence for premutagenic adenine or thymine DNA adducts. Guttenplan, J.B., Hu, Y.C. Mutat. Res. (1984) [Pubmed]
  12. DNA damage and cytotoxicity in pancreatic beta-cells expressing human CYP2E1. Lees Murdock, D.J., Barnett, Y.A., Barnett, C.R. Biochem. Pharmacol. (2004) [Pubmed]
  13. Protective role of dietary fibre on N-nitrosopyrrolidine-induced toxicity in hypercholesterolemic rats. Mittal, G., Vadhera, S., Brar, A.P., Soni, G. Human & experimental toxicology (2007) [Pubmed]
  14. Detection of N-nitrosamines in the saliva of habitual chewers of tobacco. Sipahimalani, A.T., Chadha, M.S., Bhide, S.V., Pratap, A.I., Nair, J. Food Chem. Toxicol. (1984) [Pubmed]
  15. Attempt to adsorb N-nitrosamines in solution by use of zeolites. Zhu, J.H., Yan, D., Xai, J.R., Ma, L.L., Shen, B. Chemosphere (2001) [Pubmed]
  16. Metabolism of the liver carcinogen N-nitrosopyrrolidine by rat liver microsomes. Hecker, L.I., Farrelly, J.G., Smith, J.H., Saavedra, J.E., Lyon, P.A. Cancer Res. (1979) [Pubmed]
  17. Metabolism of N-nitrosamines by cultured human and rat esophagus. Autrup, H., Stoner, G.D. Cancer Res. (1982) [Pubmed]
  18. Metabolism of chemical carcinogens by cultured human and rat bladder epithelial cells. Autrup, H., Grafstrom, R.C., Christensen, B., Kieler, J. Carcinogenesis (1981) [Pubmed]
  19. N-Nitrosopyrrolidine formation in bacon. Tricker, A.R., Perkins, M.J., Massey, R.C., McWeeny, D.J. Food additives and contaminants. (1985) [Pubmed]
  20. In vitro metabolism of N-nitrosopyrrolidine by rat lung subcellular fractions: alpha-hydroxylation in a non-target tissue. Hecker, L.I. Chem. Biol. Interact. (1980) [Pubmed]
  21. Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters. McCoy, G.D., Hecht, S.S., Katayama, S., Wynder, E.L. Cancer Res. (1981) [Pubmed]
  22. Nitrate, nitrite and volatile N-nitroso compounds in the urine of Schistosoma haematobium and Schistosoma mansoni infected patients. Mostafa, M.H., Helmi, S., Badawi, A.F., Tricker, A.R., Spiegelhalder, B., Preussmann, R. Carcinogenesis (1994) [Pubmed]
  23. Studies of the metabolic bioactivation of n-nitrosopyrrolidine in the rat. Cottrell, R.C., Blowers, S.D., Walters, D.G., Lake, B.G., Purchase, R., Phillips, J.C., Gangolli, S.D. Carcinogenesis (1983) [Pubmed]
  24. Reconstitution of rabbit liver microsomal N-nitrosopyrrolidine alpha-hydroxylase activity. McCoy, G.D., Koop, D.R. Cancer Res. (1988) [Pubmed]
  25. The effect of substituents on the carcinogenicity of n-nitrosopyrrolidine in Sprague-Dawley rats. Lijinsky, W., Taylor, H.W. Cancer Res. (1976) [Pubmed]
  26. Volatile nitrosamine levels in common foods from Tunisia, south China and Greenland, high-risk areas for nasopharyngeal carcinoma (NPC). Poirier, S., Ohshima, H., de-Thé, G., Hubert, A., Bourgade, M.C., Bartsch, H. Int. J. Cancer (1987) [Pubmed]
  27. Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Wong, H.L., Murphy, S.E., Hecht, S.S. Chem. Res. Toxicol. (2005) [Pubmed]
  28. Evidence for metabolic alpha hydroxylation of N-nitrosopyrrolidine. Hecht, S.S., Chen, C.B., Hoffmann, D. Cancer Res. (1978) [Pubmed]
  29. Identification of crotonaldehyde as a hepatic microsomal metabolite formed by alpha-hydroxylation of the carcinogen N-nitrosopyrrolidine. Wang, M.Y., Chung, F.L., Hecht, S.S. Chem. Res. Toxicol. (1988) [Pubmed]
  30. Comparison of liver tumor frequencies after intermittent oral administration of different doses of N-nitrosopyrrolidine in Sprague-Dawley rats. Hoos, A., Habs, M., Schmähl, D. Cancer Lett. (1985) [Pubmed]
  31. Studies on the distribution and metabolism of N-[14C]nitrosopyrrolidine in mice. Johansson-Brittebo, E., Tjälve, H. Chem. Biol. Interact. (1979) [Pubmed]
  32. Analysis of volatile N-nitrosamines using gas chromatography with Coulson detector:estimation of N-nitrosopyrrolidine by thin-layer chromatography with fluorimetric detection. Sen, N.P. IARC scientific publications. (1978) [Pubmed]
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