Disease relevance of N-NITROSOPIPERIDINE

• The delta3-isomer produced hemangioendothelial sarcomas in the liver, which were absent in the tumor spectrum of the delta2-isomer and N-nitrosopiperidine [1].
• When a neutral solution of N-nitrosomorpholine, N-nitrosopyrrolidine, or N-nitrosopiperidine was irradiated with near-ultraviolet light, the solution became mutagenic to Salmonella typhimurium TA100 in the absence of metabolic activation [2].

High impact information on N-NITROSOPIPERIDINE

• The results show that the carcinogens, N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodipropylamine, N-nitrosodibutylamine, and 1-nitrosopiperidine all made dose- and time-related increases in the number of single-strand breaks in rat hepatocytes [3].
• Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P450 2A3 [4].
• A comparative fine structural investigation was carried out on the long-term effects on rat liver of chronic exposure to the carcinogen, N-nitrosopiperidine (NPIP) and its non-carcinogenic derivative, 2,2',6,6'-tetramethyl-N-nitrosopiperidine [5].
• N'-Nitrosonornicotine (NNN) and N-nitrosopiperidine (NPIP) are potent esophageal and nasal cavity carcinogens in rats and pulmonary carcinogens in mice [6].
• This higher dose of 1-nitrosopiperidine also increased hepatic ornithine decarboxylase activity by 9-fold [7].

Biological context of N-NITROSOPIPERIDINE

• 1-Nitrosopiperidine (120 mg/kg, 3/5 LD50) caused DNA damage in rat liver and esophagus but not in leukocytes [7].
• N-Nitrosopiperidine (NP) and various derivatives were fed to Drosophila melanogaster males over a wide concentration range in order to assess their mutagenic potency in the induction of X-linked recessive lethals and chromosome loss [8].

Anatomical context of N-NITROSOPIPERIDINE

• In a study of rubber nipples from one manufacturer, N-nitrosodimethylamine, N-nitrosodiethylamine and N-nitrosopiperidine were determined by gas chromatography, using a thermal energy analyser, and their presence was confirmed by mass spectrometry with average levels of individual nitrosamines ranging from 22 to 281 ppb [9].
• Effect of ascorbic acid and some reducing agents on N-nitrosopiperidine metabolism by liver microsomes [10].

Associations of N-NITROSOPIPERIDINE with other chemical compounds

• The effect of ascorbic acid on the oxidation of N-nitrosopiperidine by a microsomal preparation obtained from guinea-pig liver has been examined [10].
• Findings of the controlled column experiments suggest that N-nitrosodimethylamine and six other N-nitrosamines (N-nitrosodiethylamine, N-nitrosomethylethylamine, N-nitroso-n-propylamine, N-nitrosodi-n-butylamine, N-nitrosopiperidine, and N-nitrosopyrrolidine) are biodegradable under oxic and anoxic oxidation-reduction conditions [11].
• Alpha-hydroxylation in the metabolism of N-nitrosopiperidine by rat liver microsomes: formation of 5-hydroxypentanal [12].
• Added water (ca. 1%) in acetonitrile had essentially no effect on the electrochemistry of simple dialkylnitrosamines, whereas the first anodic peak of N-nitrosopiperidine was increased and the formation of N-nitropiperidine was inhibited in the macroscale electrolysis [13].

References