Multiple-lead QRS changes with exercise testing. Diagnostic value and hemodynamic implications.
To evaluate the diagnostic potential and hemodynamic significance of exercise-induced multiple-lead QRS changes, we studied exercise test responses in 230 patients with chest pain syndromes undergoing Bruce protocol exercise tests. When increases in the R waves of multiple ECG leads (epsilon R) plus ST segment change greater than 1 mm were present, 74 of 75 patients (99%) had coronary disease; this was a higher percentage than that achieved with either measurement alone or when ST change was combined with increase in R in a single lead. Sixty-four of the 75 patients (85%) had multivessel disease, the most severe form of coronary artery disease. Left ventricular end-diastolic pressure (both at rest and after left ventriculography), presence and degree of resting ventricular asynergy, and ejection fraction were all significantly more abnormal in patients whose epsilon R increased, regardless of ST-segment change. Further, in patients who stopped exercise because of cardiac symptoms, exercise duration and the product of heart rate times blood pressure were significantly lower when epsilon R increased. Thus, the mechanism for the increase in epsilon R with exercise in patients with coronary artery disease appears to be related to abnormalities in left ventricular function.[1]References
- Multiple-lead QRS changes with exercise testing. Diagnostic value and hemodynamic implications. Berman, J.L., Wynne, J., Cohn, P.F. Circulation (1980) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
