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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Electrocardiography

  • The ECG category and creatine kinase level at admission remained highly predictive of death and myocardial infarction after multivariate adjustment for the significant baseline predictors of events [1].
  • Dyspnea or angina developed in 69 patients who took sildenafil and 70 patients who took placebo (P =.89); exercise electrocardiography was positive in 12 patients (11%) who took sildenafil and 17 patients (16%) who took placebo (P =.09) [2].
  • 214 patients were studied in a randomised trial to determine whether administraiton of intravenous atenolol within 12 hours of chest pain reduced eventual infarct size, as estimated by cumulative enzyme release and by ECG changes [3].
  • The plasma diltiazem concentration was 13.9 +/- 29 ng/ml 3 hours after ingestion and was significantly (p less than 0.05) related to the increased time to the onset of important ST-segment depression (r = 0.65) and to the decrease in the extent of myocardial ischemia observed in all 12 ECG leads (r = -0.61) compared with placebo [4].
  • Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography [5].

Psychiatry related information on Electrocardiography


High impact information on Electrocardiography

  • PATIENTS: All symptomatic patients who underwent exercise thallium testing between 1989 and 1991,939 of whom had nonspecific ST-T abnormalities and 1466 of whom had normal findings on resting ECG [11].
  • CONCLUSIONS: Based on these very large cohort studies, for individuals with favorable levels of cholesterol and blood pressure who do not smoke and do not have diabetes, MI, or ECG abnormalities, long-term mortality is much lower and longevity is much greater [12].
  • CONTEXT: Minor electrocardiographic (ECG) ST-T abnormalities are common, but their prognostic importance has not been fully determined [13].
  • The surviving child showed ECG and echocardiographic evidence of myocardial injury and transient elevation of the MB fraction of serum creatinine phosphokinase [14].
  • The acute synergistic cardiotoxic effects occurred with doxorubicin dosages that were severalfold less than those associated with only mild and transient ECG disturbances under normothermic conditions [15].

Chemical compound and disease context of Electrocardiography


Biological context of Electrocardiography


Anatomical context of Electrocardiography


Associations of Electrocardiography with chemical compounds

  • When starting quinidine therapy in patients who are taking digoxin, the clinical course, ECG, and serum digoxin level should be followed closely [31].
  • Continuous Holter ECG tapes were analyzed before, during, and after mexiletine [32].
  • Therefore, careful follow-up with repeated ECG monitoring seems to be indicated when clonidine is given to a patient with suspected cardiac conduction disease, especially if the patient is concurrently receiving digitalis therapy [33].
  • 11 patients with chronic, stable, effort angina, off medication apart from glyceryl trinitrate, were monitored continuously by electrocardiogram (ECG) during normal, unrestricted daily activity [34].
  • The main data included the occurrence of vomiting before admission, plasma, and urinary potassium concentration at admission, whole blood chloroquine concentration on admission, haemodynamic parameters and ECG, administration of catecholamines and outcome [35].

Gene context of Electrocardiography

  • CONCLUSIONS: We observed significantly longer conduction intervals on baseline ECG in patients with established SCN5A mutations (PQ and HV interval and, upon class I drugs, more QRS increase) [36].
  • Furthermore, we provide evidence that ECG induces the ATF3 transcription factor, followed by NAG-1 induction at the transcriptional level in a p53-independent manner [37].
  • We found that at dosages which are known to modify ECG patterns, DSIP is unable to modify spontaneous or arginine chlorhydrate-induced GH and PRL secretion [38].
  • CONCLUSION: There are no significant differences in clinical presentation, ECG parameters, and cardiac events among LQT1 patients with different locations of KCNQ1 mutations [39].
  • EGCG and to a lesser extent ECG prevented the induction of VCAM-1 expression in a concentration-dependent manner after stimulation with TNF-alpha, whereas EC and EGC were without effect [40].

Analytical, diagnostic and therapeutic context of Electrocardiography

  • The specificity was higher for dipyridamole echocardiography than for exercise ECG (90% versus 51%, P < .001) [41].
  • The sensitivity to recognize group II was 76% for thallium-201 scintigraphy, 11% for ECG during the pain free period; 70% for ECG during angina; 94% for the combination of either positive scans or abnormal ECG [42].
  • ST elevation during exercise occurred in the same ECG leads as during spontaneous attacks at rest, and was always associated with a large perfusion defect on the exercise thallium scan [43].
  • The dipyridamole time also provided independent and additional prognostic information when it was adjusted for age, diabetes, resting ECG, and exercise stress test according to a modified, interactive stepwise procedure [41].
  • Myocardial imaging with thallium-201 at rest and during exercise. Comparison with coronary arteriography and resting and stress electrocardiography [44].


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  2. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial. Arruda-Olson, A.M., Mahoney, D.W., Nehra, A., Leckel, M., Pellikka, P.A. JAMA (2002) [Pubmed]
  3. Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial. Yusuf, S., Ramsdale, D., Peto, R., Furse, L., Bennett, D., Bray, C., Sleight, P. Lancet (1980) [Pubmed]
  4. Increased exercise tolerance and reduced electrocardiographic ischemia with diltiazem in patients with stable angina pectoris. Wagniart, P., Ferguson, R.J., Chaitman, B.R., Achard, F., Benacerraf, A., Delanguenhagen, B., Morin, B., Pasternac, A., Bourassa, M.G. Circulation (1982) [Pubmed]
  5. Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography. Lattanzi, F., Picano, E., Bolognese, L., Piccinino, C., Sarasso, G., Orlandini, A., L'Abbate, A. Circulation (1991) [Pubmed]
  6. ECG changes during haloperidol and pimozide treatment of Tourette's disorder. Fulop, G., Phillips, R.A., Shapiro, A.K., Gomes, J.A., Shapiro, E., Nordlie, J.W. The American journal of psychiatry. (1987) [Pubmed]
  7. Cardiac arrhythmias after abrupt clonidine withdrawal. Peters, R.W., Hamilton, B.P., Hamilton, J., Kuzbida, G., Pavlis, R. Clin. Pharmacol. Ther. (1983) [Pubmed]
  8. Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial. Gilbert, D.L., Batterson, J.R., Sethuraman, G., Sallee, F.R. Journal of the American Academy of Child and Adolescent Psychiatry. (2004) [Pubmed]
  9. Cardiac autonomic mechanisms associated with borderline hypertension under varying behavioral demands: evidence for attenuated parasympathetic tone but not for enhanced beta-adrenergic activity. Grossman, P., Brinkman, A., de Vries, J. Psychophysiology. (1992) [Pubmed]
  10. Electrocardiographic effects of rivastigmine. Morganroth, J., Graham, S., Hartman, R., Anand, R. Journal of clinical pharmacology. (2002) [Pubmed]
  11. Prognostic value of a treadmill exercise score in symptomatic patients with nonspecific ST-T abnormalities on resting ECG. Kwok, J.M., Miller, T.D., Christian, T.F., Hodge, D.O., Gibbons, R.J. JAMA (1999) [Pubmed]
  12. Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women. Stamler, J., Stamler, R., Neaton, J.D., Wentworth, D., Daviglus, M.L., Garside, D., Dyer, A.R., Liu, K., Greenland, P. JAMA (1999) [Pubmed]
  13. Association of nonspecific minor ST-T abnormalities with cardiovascular mortality: the Chicago Western Electric Study. Daviglus, M.L., Liao, Y., Greenland, P., Dyer, A.R., Liu, K., Xie, X., Huang, C.F., Prineas, R.J., Stamler, J. JAMA (1999) [Pubmed]
  14. Acute phosphine poisoning aboard a grain freighter. Epidemiologic, clinical, and pathological findings. Wilson, R., Lovejoy, F.H., Jaeger, R.J., Landrigan, P.L. JAMA (1980) [Pubmed]
  15. Hyperthermia potentiates doxorubicin-related cardiotoxic effects. Kim, Y.D., Lees, D.E., Lake, C.R., Whang-Peng, J., Schuette, W., Smith, R., Bull, J. JAMA (1979) [Pubmed]
  16. Myocardial toxic effects during recombinant interleukin-2 therapy. Nora, R., Abrams, J.S., Tait, N.S., Hiponia, D.J., Silverman, H.J. J. Natl. Cancer Inst. (1989) [Pubmed]
  17. Angina pectoris caused by coronary microvascular spasm. Mohri, M., Koyanagi, M., Egashira, K., Tagawa, H., Ichiki, T., Shimokawa, H., Takeshita, A. Lancet (1998) [Pubmed]
  18. Noninvasive prediction of multivessel disease after myocardial infarction. Dunn, R.F., Freedman, B., Bailey, I.K., Uren, R., Kelly, D.T. Circulation (1980) [Pubmed]
  19. Extracoronary atherosclerotic plaque at multiple sites and total coronary calcification deposit in asymptomatic men. Association with coronary risk profile. Simon, A., Giral, P., Levenson, J. Circulation (1995) [Pubmed]
  20. Optimal diagnosis in acute myocardial infarction. A cost-effectiveness study. Grande, P., Christiansen, C., Pedersen, A., Christensen, M.S. Circulation (1980) [Pubmed]
  21. Neuropeptide-Y. A peptide found in human coronary arteries constricts primarily small coronary arteries to produce myocardial ischemia in dogs. Maturi, M.F., Greene, R., Speir, E., Burrus, C., Dorsey, L.M., Markle, D.R., Maxwell, M., Schmidt, W., Goldstein, S.R., Patterson, R.E. J. Clin. Invest. (1989) [Pubmed]
  22. Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease. Benotti, J.R., Grossman, W., Braunwald, E., Carabello, B.A. Circulation (1980) [Pubmed]
  23. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Pollick, C., Giacomini, K.M., Blaschke, T.F., Nelson, W.L., Turner-Tamiyasu, K., Briskin, V., Popp, R.L. Circulation (1982) [Pubmed]
  24. AHA special report. Recommendations for standards of instrumentation and practice in the use of ambulatory electrocardiography. The Task Force of the Committee on Electrocardiography and Cardiac Electrophysiology of the Council on Clinical Cardiology. Sheffield, L.T., Berson, A., Bragg-Remschel, D., Gillette, P.C., Hermes, R.E., Hinkle, L., Kennedy, H., Mirvis, D.M., Oliver, C. Circulation (1985) [Pubmed]
  25. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. del Monte, F., Lebeche, D., Guerrero, J.L., Tsuji, T., Doye, A.A., Gwathmey, J.K., Hajjar, R.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Prolonged His-Q interval in chronic bifascicular block. Relation to impending complete heart block. Vera, Z., Mason, D.T., Fletcher, R.D., Awan, N.A., Massumi, R.A. Circulation (1976) [Pubmed]
  27. Acute arterial hypertension during spontaneous angina in patients with fixed coronary stenosis and exertional angina: an associated rather than a triggering phenomenon. Figueras, J., Cinca, J. Circulation (1981) [Pubmed]
  28. Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. Yoshida, M., Minamisawa, S., Shimura, M., Komazaki, S., Kume, H., Zhang, M., Matsumura, K., Nishi, M., Saito, M., Saeki, Y., Ishikawa, Y., Yanagisawa, T., Takeshima, H. J. Biol. Chem. (2005) [Pubmed]
  29. Cost-effectiveness analysis of patient management alternatives after uncomplicated myocardial infarction: a model. Dittus, R.S., Roberts, S.D., Adolph, R.J. J. Am. Coll. Cardiol. (1987) [Pubmed]
  30. Pre-operative sinus node function in adult patients with atrial septal defect (ostium secundum type). Benedini, G., Affatato, A., Bellandi, M., Cuccia, C., Niccoli, L., Renaldini, E., Visioli, O. Eur. Heart J. (1985) [Pubmed]
  31. Interaction between quinidine and digoxin. Leahey, E.B., Reiffel, J.A., Drusin, R.E., Heissenbuttel, R.H., Lovejoy, W.P., Bigger, J.T. JAMA (1978) [Pubmed]
  32. Mexiletine. Use in control of chronic drug-resistant ventricular arrhythmia. Abinader, E.G., Cooper, M. JAMA (1979) [Pubmed]
  33. Effect of clonidine on atrioventricular conduction. Kibler, L.E., Gazes, P.C. JAMA (1977) [Pubmed]
  34. Role of heart rate in pathophysiology of chronic stable angina. Chierchia, S., Gallino, A., Smith, G., Deanfield, J., Morgan, M., Croom, M., Maseri, A. Lancet (1984) [Pubmed]
  35. Hypokalaemia related to acute chloroquine ingestion. Clemessy, J.L., Favier, C., Borron, S.W., Hantson, P.E., Vicaut, E., Baud, F.J. Lancet (1995) [Pubmed]
  36. Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. Smits, J.P., Eckardt, L., Probst, V., Bezzina, C.R., Schott, J.J., Remme, C.A., Haverkamp, W., Breithardt, G., Escande, D., Schulze-Bahr, E., LeMarec, H., Wilde, A.A. J. Am. Coll. Cardiol. (2002) [Pubmed]
  37. Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Baek, S.J., Kim, J.S., Jackson, F.R., Eling, T.E., McEntee, M.F., Lee, S.H. Carcinogenesis (2004) [Pubmed]
  38. Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women. Giusti, M., Carraro, A., Porcella, E., Valenti, S., Nicora, D., Sessarego, P., Giordano, G. Psychoneuroendocrinology (1993) [Pubmed]
  39. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. Zareba, W., Moss, A.J., Sheu, G., Kaufman, E.S., Priori, S., Vincent, G.M., Towbin, J.A., Benhorin, J., Schwartz, P.J., Napolitano, C., Hall, W.J., Keating, M.T., Qi, M., Robinson, J.L., Andrews, M.L. J. Cardiovasc. Electrophysiol. (2003) [Pubmed]
  40. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Ludwig, A., Lorenz, M., Grimbo, N., Steinle, F., Meiners, S., Bartsch, C., Stangl, K., Baumann, G., Stangl, V. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  41. Diagnostic and prognostic value of dipyridamole echocardiography in patients with suspected coronary artery disease. Comparison with exercise electrocardiography. Severi, S., Picano, E., Michelassi, C., Lattanzi, F., Landi, P., Distante, A., L'Abbate, A. Circulation (1994) [Pubmed]
  42. Thallium-201 scintigraphy in unstable angina pectoris. Wackers, F.J., Lie, K.I., Liem, K.L., Sokole, E.B., Samson, G., van der Schoot, J.B., Durrer, D. Circulation (1978) [Pubmed]
  43. Exercise testing in patients with variant angina: results, correlation with clinical and angiographic features and prognostic significance. Waters, D.D., Szlachcic, J., Bourassa, M.G., Scholl, J.M., Théroux, P. Circulation (1982) [Pubmed]
  44. Myocardial imaging with thallium-201 at rest and during exercise. Comparison with coronary arteriography and resting and stress electrocardiography. Ritchie, J.L., Trobaugh, G.B., Hamilton, G.W., Gould, K.L., Narahara, K.A., Murray, J.A., Williams, D.L. Circulation (1977) [Pubmed]
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