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MeSH Review

Chest Pain

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Disease relevance of Chest Pain


Psychiatry related information on Chest Pain


High impact information on Chest Pain

  • No patient had chest pain or ischemic electrocardiographic changes after cocaine use or smoking [11].
  • During the treatment phase, the imipramine group had a mean (+/- SD) reduction of 52 +/- 25 percent in episodes of chest pain, the clonidine group had a reduction of 39 +/- 51 percent, and the placebo group a reduction of 1 +/- 86 percent, all as compared with the placebo phase of the trial [12].
  • Within four hours of the onset of chest pain, tissue plasminogen activator (t-PA) was given to 44 patients, and 62 were treated conventionally [13].
  • Panic disorder, which is found in about 1.5 percent of the population at some time in their lives, includes recurrent episodes of sudden, unpredictable, intense fear accompanied by symptoms such as palpitations, chest pain, and faintness [14].
  • Nifedipine for relief of esophageal chest pain [15].

Chemical compound and disease context of Chest Pain

  • Thirty-five patients with atypical chest pain were given ergonovine maleate as a provocative test for coronary spasm [16].
  • With verapamil administration, the frequency of both chest pain and transient ST-segment deviations was sharply diminished [17].
  • We conclude that the intrapleural administration of tetracycline in patients with spontaneous pneumothorax significantly reduces the rate of ipsilateral recurrence but is associated with intense chest pain [18].
  • Coronary vasodilating responses to SP were comparable in patients with variant angina and those with atypical chest pain [19].
  • During a 72-h period after hospital admission significant decreases in C1, C4, and C3 occurred in six patients with recent chest pain but no evidence of acute myocardial infarction [20].

Biological context of Chest Pain


Anatomical context of Chest Pain


Gene context of Chest Pain

  • This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS) [30].
  • Myoglobin, CK-MB mass, cTnT and cTnI are nowadays widely used in diagnosing patients with acute chest pain [31].
  • Patients with unstable angina had significantly higher levels of IL-1Ra than stable patients [158 (110-224) vs 108 (95-154) pg/ml, P = 0.002] and individuals with chest pain and normal coronary angiogram [110 (97-123) pg/ml, P: = 0.038] [32].
  • Levels of IL-2 and IL-10 measured following chest pain in unstable patients, as well as their consecutive determinations in MI patients did not show any change dynamics, that is, they were persistently elevated [33].
  • There were no significant differences in PAI activity and TPA antigen levels between the stable exertional angina group and the chest pain syndrome group [34].

Analytical, diagnostic and therapeutic context of Chest Pain


  1. Cocaine-induced coronary-artery vasoconstriction. Lange, R.A., Cigarroa, R.G., Yancy, C.W., Willard, J.E., Popma, J.J., Sills, M.N., McBride, W., Kim, A.S., Hillis, L.D. N. Engl. J. Med. (1989) [Pubmed]
  2. Chagas' heart disease in the United States. Hagar, J.M., Rahimtoola, S.H. N. Engl. J. Med. (1991) [Pubmed]
  3. Scintigraphic evaluation of suspected acute myocardial infarction. Kan, M.K., Hopkins, G.B., Carroll, C.F. JAMA (1977) [Pubmed]
  4. Esophageal motor dysfunction in systemic lupus erythematosus. Two cases with unusual features. Peppercorn, M.A., Docken, W.P., Rosenberg, S. JAMA (1979) [Pubmed]
  5. 'Esophageal angina' as the cause of chest pain. Davies, H.A., Jones, D.B., Rhodes, J. JAMA (1982) [Pubmed]
  6. Major depression, panic disorder, and mitral valve prolapse in patients who complain of chest pain. Carney, R.M., Freedland, K.E., Ludbrook, P.A., Saunders, R.D., Jaffe, A.S. Am. J. Med. (1990) [Pubmed]
  7. History of anxiety disorders is associated with a decreased likelihood of angiographic coronary artery disease in women with chest pain: the WISE study. Rutledge, T., Reis, S.E., Olson, M., Owens, J., Kelsey, S.F., Pepine, C.J., Reichek, N., Rogers, W.J., Merz, C.N., Sopko, G., Cornell, C.E., Sharaf, B., Matthews, K.A. J. Am. Coll. Cardiol. (2001) [Pubmed]
  8. Abnormal cardiac sensitivity in patients with chest pain and normal coronary arteries. Cannon, R.O., Quyyumi, A.A., Schenke, W.H., Fananapazir, L., Tucker, E.E., Gaughan, A.M., Gracely, R.H., Cattau, E.L., Epstein, S.E. J. Am. Coll. Cardiol. (1990) [Pubmed]
  9. Chest pain during use of bupropion as an aid in smoking cessation. de Graaf, L., Diemont, W.L. British journal of clinical pharmacology. (2003) [Pubmed]
  10. Heart failure in the general population of men--morbidity, risk factors and prognosis. Wilhelmsen, L., Rosengren, A., Eriksson, H., Lappas, G. J. Intern. Med. (2001) [Pubmed]
  11. Coronary-artery vasoconstriction induced by cocaine, cigarette smoking, or both. Moliterno, D.J., Willard, J.E., Lange, R.A., Negus, B.H., Boehrer, J.D., Glamann, D.B., Landau, C., Rossen, J.D., Winniford, M.D., Hillis, L.D. N. Engl. J. Med. (1994) [Pubmed]
  12. Imipramine in patients with chest pain despite normal coronary angiograms. Cannon, R.O., Quyyumi, A.A., Mincemoyer, R., Stine, A.M., Gracely, R.H., Smith, W.B., Geraci, M.F., Black, B.C., Uhde, T.W., Waclawiw, M.A. N. Engl. J. Med. (1994) [Pubmed]
  13. Decreased incidence of ventricular late potentials after successful thrombolytic therapy for acute myocardial infarction. Gang, E.S., Lew, A.S., Hong, M., Wang, F.Z., Siebert, C.A., Peter, T. N. Engl. J. Med. (1989) [Pubmed]
  14. Suicidal ideation and suicide attempts in panic disorder and attacks. Weissman, M.M., Klerman, G.L., Markowitz, J.S., Ouellette, R. N. Engl. J. Med. (1989) [Pubmed]
  15. Nifedipine for relief of esophageal chest pain. Cargill, G., Theodore, C., Paolaggi, J.A. N. Engl. J. Med. (1982) [Pubmed]
  16. Predictability of the response to the ergonovine test. Value in the diagnosis of coronary spasm. Gerry, J.L., Achuff, S.C., Becker, L.C., Pond, M.S., Greene, H.L. JAMA (1979) [Pubmed]
  17. Verapamil administration in variant angina pectoris. Efficacy shown by ecg monitoring. Johnson, S.M., Mauritson, D.R., Willerson, J.T., Cary, J.R., Hillis, L.D. JAMA (1981) [Pubmed]
  18. Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax. Results of a Department of Veterans Affairs cooperative study. Light, R.W., O'Hara, V.S., Moritz, T.E., McElhinney, A.J., Butz, R., Haakenson, C.M., Read, R.C., Sassoon, C.S., Eastridge, C.E., Berger, R. JAMA (1990) [Pubmed]
  19. Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina. Egashira, K., Inou, T., Yamada, A., Hirooka, Y., Takeshita, A. J. Clin. Invest. (1992) [Pubmed]
  20. Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction. Pinckard, R.N., Olson, M.S., Giclas, P.C., Terry, R., Boyer, J.T., O'Rourke, R.A. J. Clin. Invest. (1975) [Pubmed]
  21. Effect of surgical reduction of left ventricular outflow obstruction on hemodynamics, coronary flow, and myocardial metabolism in hypertrophic cardiomyopathy. Cannon, R.O., McIntosh, C.L., Schenke, W.H., Maron, B.J., Bonow, R.O., Epstein, S.E. Circulation (1989) [Pubmed]
  22. Enhanced insulin response relates to acetylcholine-induced vasoconstriction in vasospastic angina. Shimabukuro, M., Shinzato, T., Higa, S., Chibana, T., Yoshida, H., Nagamine, F., Murakami, K., Takasu, N. J. Am. Coll. Cardiol. (1995) [Pubmed]
  23. Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. Boehrer, J.D., Moliterno, D.J., Willard, J.E., Hillis, L.D., Lange, R.A. Am. J. Med. (1993) [Pubmed]
  24. Cerebral potentials evoked by oesophageal distension in patients with non-cardiac chest pain. Smout, A.J., DeVore, M.S., Dalton, C.B., Castell, D.O. Gut (1992) [Pubmed]
  25. Propranolol disposition after acute myocardial infarction. Paxton, J.W., Norris, R.M. Clin. Pharmacol. Ther. (1984) [Pubmed]
  26. Edrophonium: a useful provocative test for esophageal chest pain. Richter, J.E., Hackshaw, B.T., Wu, W.C., Castell, D.O. Ann. Intern. Med. (1985) [Pubmed]
  27. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Treasure, C.B., Vita, J.A., Cox, D.A., Fish, R.D., Gordon, J.B., Mudge, G.H., Colucci, W.S., Sutton, M.G., Selwyn, A.P., Alexander, R.W. Circulation (1990) [Pubmed]
  28. Role of adenosine in pathogenesis of anginal pain. Crea, F., Pupita, G., Galassi, A.R., el-Tamimi, H., Kaski, J.C., Davies, G., Maseri, A. Circulation (1990) [Pubmed]
  29. Value of plasma fibrin D-dimers for detection of acute aortic dissection. Eggebrecht, H., Naber, C.K., Bruch, C., Kröger, K., von Birgelen, C., Schmermund, A., Wichert, M., Bartel, T., Mann, K., Erbel, R. J. Am. Coll. Cardiol. (2004) [Pubmed]
  30. Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina. Maruyoshi, H., Kojima, S., Funahashi, T., Miyamoto, S., Hokamaki, J., Soejima, H., Sakamoto, T., Kawano, H., Yoshimura, M., Kitagawa, A., Matsuzawa, Y., Ogawa, H. Thromb. Haemost. (2004) [Pubmed]
  31. Laboratory diagnosis of patients with acute chest pain. Penttilä, I., Penttilä, K., Rantanen, T. Clin. Chem. Lab. Med. (2000) [Pubmed]
  32. Interleukin-1 receptor antagonist: a sensitive marker of instability in patients with coronary artery disease. Patti, G., D'Ambrosio, A., Dobrina, A., Dicuonzo, G., Giansante, C., Fiotti, N., Abbate, A., Guarnieri, G., Di Sciascio, G. J. Thromb. Thrombolysis (2002) [Pubmed]
  33. Serum tumour necrosis factor-alpha, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes. Mizia-Stec, K., Gasior, Z., Zahorska-Markiewicz, B., Janowska, J., Szulc, A., Jastrzebska-Maj, E., Kobielusz-Gembala, I. Coron. Artery Dis. (2003) [Pubmed]
  34. Plasma plasminogen activator inhibitor activity and tissue plasminogen activator levels in patients with unstable angina and those with coronary spastic angina. Masuda, T., Yasue, H., Ogawa, H., Misumi, I., Sakamoto, T., Okubo, H., Miyao, Y., Kato, H. Am. Heart J. (1992) [Pubmed]
  35. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Kern, M.K., Birn, R.M., Jaradeh, S., Jesmanowicz, A., Cox, R.W., Hyde, J.S., Shaker, R. Gastroenterology (1998) [Pubmed]
  36. Effects of sublingual nitroglycerin on resting pulmonary gas exchange and hemodynamics in man. Mookherjee, S., Fuleihan, D., Warner, R.A., Vardan, S., Obeid, A.I. Circulation (1978) [Pubmed]
  37. Dipyridamole stress echocardiography for risk stratification in hypertensive patients with chest pain. Cortigiani, L., Paolini, E.A., Nannini, E. Circulation (1998) [Pubmed]
  38. Routine serum enzyme tests in the diagnosis of acute myocardial infarction. Cost-effectiveness. Fisher, M.L., Kelemen, M.H., Collins, D., Morris, F., Moran, G.W., Carliner, N.H., Plotnick, G.D. Arch. Intern. Med. (1983) [Pubmed]
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