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Chiou, G.C. et al.

Chemotherapy of neuroblastoma in mice with anticancer agents.

Neuroblastoma-inoculated A/J mice were treated with various anticancer chemotherapeutic agents, including cyclophosphamide, daunorubicin, vincristine, alpha-bungarotoxin, dihydroxytryptamine, and diaminopropane. Cyclophosphamide and diaminopropane inhibited neuroblastoma as effectively as bromoacetylcholine and bromacetate. The effectiveness of these drugs could be related to the inhibition of ornithine decarboxylase, a rate-limiting enzyme for the synthesis of polyamines.[1]

References

Chemotherapy of neuroblastoma in mice with anticancer agents. Chiou, G.C., Martin, M.K. Journal of pharmaceutical sciences. (1980) [Pubmed]

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