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Chemical Compound Review

Amidol     2,4-diaminophenol

Synonyms: Diaminopropane, SureCN27284, AG-H-94059, ANW-52828, NSC5727, ...
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Disease relevance of Dianol

  • To utilize the potential of this finding in developing an anti-gene strategy for breast cancer, we treated MCF-7 cells with a 37mer oligonucleotide to form triplex DNA in the up-stream regulatory region of the c-myc oncogene in the presence of DAP [1].
  • Although the combined use of DAP with bombesin had little or no influence on the location, size, histological features, or depth of involvement of intestinal cancers, the incidence of their metastasis was significantly reduced [2].
  • Rats were given drinking water containing 2.5 g/l of DAP ad libitum and received alternate-day injections of 1 mg/kg body weight of tetragastrin in depot form after 25 weeks of oral treatment with MNNG [3].
  • Analysis of the polyphosphate-accumulating microflora in phosphorus-eliminating, anaerobic-aerobic activated sludge systems by using diaminopropane as a biomarker for rapid estimation of Acinetobacter spp [4].
  • Coupling of the lat and pcbAB promoters to the reporter xylE gene showed that expression from the lat and pcbAB promoters was increased by addition of diaminopropane in Streptomyces lividans [5].

High impact information on Dianol


Chemical compound and disease context of Dianol


Biological context of Dianol


Anatomical context of Dianol


Associations of Dianol with other chemical compounds


Gene context of Dianol

  • The administration of diaminopropane, an inhibitor of ornithine decarboxylase, has only limited effects on the activation of RNA synthesis by liver nuclei, which occurs 10 hr after turpentine treatment [22].
  • An inhibitor of ODC synthesis, diaminopropane (DAP), and an irreversible inhibitor of ODC activity, alpha-DL-difluoromethylornithine (alpha-DFMO), each suppressed the FCS-stimulated ODC activity when added to the culture medium [23].
  • Diaminopropane inhibits brain ornithine decarboxylase, but does not induce an ornithine decarboxylase-antizyme [24].
  • After systematic optimization separation conditions were selected: 100 mM borate buffer at pH 8.5 with 0.4 mM diaminopropane as EOF modifier [25].
  • For the production of efficient antibody diagnostics it is advisable to use amidol while in the case of highly active and concentrated sera, amidol, CrCl3 and glutaraldehyde should be employed [26].

Analytical, diagnostic and therapeutic context of Dianol


  1. Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells. Thomas, T.J., Faaland, C.A., Gallo, M.A., Thomas, T. Nucleic Acids Res. (1995) [Pubmed]
  2. Ornithine decarboxylase inhibitor attenuates bombesin enhancement of intestinal carcinogenesis and metastasis induced by azoxymethane. Iishi, H., Tatsuta, M., Baba, M., Uehara, H., Nakaizumi, A. Int. J. Cancer (1994) [Pubmed]
  3. Effect of ornithine decarboxylase inhibitor on tetragastrin treatment of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Baba, M., Taniguchi, H. Int. J. Cancer (1990) [Pubmed]
  4. Analysis of the polyphosphate-accumulating microflora in phosphorus-eliminating, anaerobic-aerobic activated sludge systems by using diaminopropane as a biomarker for rapid estimation of Acinetobacter spp. Auling, G., Pilz, F., Busse, H.J., Karrasch, S., Streichan, M., Schön, G. Appl. Environ. Microbiol. (1991) [Pubmed]
  5. Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans. Leitão, A.L., Enguita, F.J., De La Fuente, J.L., Liras, P., Martin, J.F. J. Bacteriol. (1999) [Pubmed]
  6. Ornithine decarboxylase inhibitor attenuates NaCl enhancement of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Iishi, H., Baba, M., Yano, H., Uehara, H., Nakaizumi, A. Carcinogenesis (1995) [Pubmed]
  7. Utilization of MS3 spectra for the multicomponent quantification of diastereomeric N-acetylhexosamines. Desaire, H., Leary, J.A. J. Am. Soc. Mass Spectrom. (2000) [Pubmed]
  8. Involvement of nitrogen-containing compounds in beta-lactam biosynthesis and its control. Demain, A.L., Vaishnav, P. Crit. Rev. Biotechnol. (2006) [Pubmed]
  9. Polyamines as a chemotaxonomic marker in bacterial systematics. Hamana, K., Matsuzaki, S. Crit. Rev. Microbiol. (1992) [Pubmed]
  10. Effect of diaminobutene and diaminopropane on diet-stimulated polyamine synthesis and cell proliferation in rat liver. Kameji, T., Murakami, Y., Hayashi, S. J. Biochem. (1979) [Pubmed]
  11. Compensatory route of spermidine acetylation and oxidation can supply sufficient putrescine for hepatic DNA synthesis at an early stage after partial hepatectomy in diaminopropane-treated rats. Sato, Y., Fujiwara, K. J. Biochem. (1988) [Pubmed]
  12. Specific inhibition of the synthesis of putrescine and spermidine by 1,3-diaminopropane in rat liver in vivo. Pösö, H., Kallio, A., Scalabrino, G., Jänne, J. Biochim. Biophys. Acta (1977) [Pubmed]
  13. Association constants for the interaction of double-stranded and single-stranded DNA with spermine, spermidine, putrescine, diaminopropane, N1- and N8-acetylspermidine, and magnesium: determination from analysis of the broadening of thermal denaturation curves. Morgan, J.E., Blankenship, J.W., Matthews, H.R. Arch. Biochem. Biophys. (1986) [Pubmed]
  14. Induction of an ornithine decarboxylase-antizyme by diaminopropane in chicken kidney and intestinal mucosa. Grillo, M.A., Bedino, S., Testore, G. Boll. Soc. Ital. Biol. Sper. (1980) [Pubmed]
  15. Intracellular localization of the calcium- and calmodulin antagonist fendiline. Weyhenmeyer, R., Gross, M., Maurer-Schultze, B. Arzneimittel-Forschung. (1989) [Pubmed]
  16. The in vivo effects of a polyamine analogue on tissue stem cell proliferation. Rupniak, H.T., Gladden, J.G., Paul, D. European journal of cancer & clinical oncology. (1982) [Pubmed]
  17. Effects of Exogenous Polyamines on Tropane Alkaloid Production by a Root Culture of Duboisia myoporoides. Yoshioka, T., Yamagata, H., Ithoh, A., Deno, H., Fujita, Y., Yamada, Y. Planta Med. (1989) [Pubmed]
  18. Separation of biogenic amines by micellar electrokinetic chromatography with on-line chemiluminescence detection. Liu, Y.M., Cheng, J.K. Journal of chromatography. A. (2003) [Pubmed]
  19. Chemotherapy of neuroblastoma in mice with anticancer agents. Chiou, G.C., Martin, M.K. Journal of pharmaceutical sciences. (1980) [Pubmed]
  20. Antiproliferative effects of N1,N4-dibenzylputrescine in human and rodent tumor cells. Aizencang, G., Harari, P., Buldain, G., Guerra, L., Pickart, M., Hernandez, P., Frydman, B. Cell. Mol. Biol. (Noisy-le-grand) (1998) [Pubmed]
  21. Polyamines of primitive apterygotan insects: springtails, silverfish and a bristletail. Hamana, K., Uemiya, H., Niitsu, M. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2004) [Pubmed]
  22. Activation of polyamine biosynthetic decarboxylases during the acute phase response of rat liver. Scalabrino, G., Ferioli, M.E., Piccoletti, R., Bernelli-Zazzera, A. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  23. Ornithine decarboxylase activity in retinal explants of goldfish undergoing optic nerve regeneration. Schwartz, M., Kohsaka, S., Agranoff, B.W. Brain Res. (1981) [Pubmed]
  24. Arginase, ornithine decarboxylase and S-adenosylmethionine decarboxylase in chicken brain and retina. Grillo, M.A., Fossa, T., Dianzani, U. Int. J. Biochem. (1983) [Pubmed]
  25. Capillary electrophoresis with a diamine EOF modifier as an approach for glutamine dipeptide containing formulations. Jaworska, M., Wilk, M., Szulińska, Z. Acta poloniae pharmaceutica. (2003) [Pubmed]
  26. Principles of constructing efficient erythrocyte immunoglobulin diagnostics. Shamardin, V.A. Journal of hygiene, epidemiology, microbiology, and immunology. (1983) [Pubmed]
  27. Attenuation of vasoactive intestinal peptide enhancement of colon carcinogenesis by ornithine decarboxylase inhibitor. Tatsuta, M., Iishi, H., Baba, M., Yamamoto, R., Uehara, H., Nakaizumi, A. Cancer Lett. (1995) [Pubmed]
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