Disease relevance of Dianol

• To utilize the potential of this finding in developing an anti-gene strategy for breast cancer, we treated MCF-7 cells with a 37mer oligonucleotide to form triplex DNA in the up-stream regulatory region of the c-myc oncogene in the presence of DAP [1].
• Although the combined use of DAP with bombesin had little or no influence on the location, size, histological features, or depth of involvement of intestinal cancers, the incidence of their metastasis was significantly reduced [2].
• Rats were given drinking water containing 2.5 g/l of DAP ad libitum and received alternate-day injections of 1 mg/kg body weight of tetragastrin in depot form after 25 weeks of oral treatment with MNNG [3].
• Analysis of the polyphosphate-accumulating microflora in phosphorus-eliminating, anaerobic-aerobic activated sludge systems by using diaminopropane as a biomarker for rapid estimation of Acinetobacter spp [4].
• Coupling of the lat and pcbAB promoters to the reporter xylE gene showed that expression from the lat and pcbAB promoters was increased by addition of diaminopropane in Streptomyces lividans [5].

High impact information on Dianol

• Administration of both NaCl and DAP significantly reduced the enhancements by NaCl of gastric carcinogenesis, ODC activity of the antral wall and the labeling index of antral epithelial cells [6].
• Rats were given drinking water with or without 2.5 g/l DAP and chow pellets with and without 10% NaCl ad libitum after 25 weeks of oral administration of MNNG [6].
• The method involves derivatizing the monosaccharides with [Co(DAP)2Cl2]Cl (where DAP is diaminopropane), and subjecting the derivatized products to collision-induced dissociation (CID) in a quadrupole ion trap mass spectrometer [7].
• The diamines putrescine, cadaverine, and diaminopropane stimulate cephamycin biosynthesis in Nocardia lactamdurans, in shake flasks and fermentors, without altering cell growth [5].
• Surprisingly, diamines such as diaminopropane, putrescine and cadaverine induce cephamycin production by actinomycetes [8].

Chemical compound and disease context of Dianol

• The absence or presence of spermidine, norspermidine or homospermidine and the occurrence of 2-hydroxyputrescine and diaminopropane are related to grouping into the alpha, beta, gamma, and delta subclasses within Proteobacteria [9].

Biological context of Dianol

• Effect of diaminobutene and diaminopropane on diet-stimulated polyamine synthesis and cell proliferation in rat liver [10].
• Compensatory route of spermidine acetylation and oxidation can supply sufficient putrescine for hepatic DNA synthesis at an early stage after partial hepatectomy in diaminopropane-treated rats [11].
• Diaminopropane likewise inhibited ornithine decarboxylase activity during later periods of liver regeneration [12].

Anatomical context of Dianol

• The effect of Mg2+, putrescine, diaminopropane, N1-acetylspermidine, N8-acetylspermidine, spermidine, and spermine on the thermal denaturation of calf thymus DNA was investigated [13].
• Induction of an ornithine decarboxylase-antizyme by diaminopropane in chicken kidney and intestinal mucosa [14].
• After 7 to 30 days exposure and development in amidol silver grains were counted above cells, nuclei and extracellular space [15].
• In contrast to the regenerating liver, DAP exerted minimal effects upon the proliferation of the gut epithelium and bone marrow elements [16].

Associations of Dianol with other chemical compounds

• The putrescine analogues diaminomethane, diaminoethane, diaminopropane, and cadaverine also increased the scopolamine content of the DUBOISIA root culture from 0.56% to the respective values of 0.86%, 0.90%, 1.06%, and 1.04% [17].
• A method of on-line chemiluminescence detection with capillary electrophoresis for biogenic amines (diaminopropane, putrescine, cadaverine and diaminohexane) labeled with N-(4-aminobutyl)-N-ethylisoluminol is reported for the first time [18].
• Cyclophosphamide and diaminopropane inhibited neuroblastoma as effectively as bromoacetylcholine and bromacetate [19].
• N1,N5-dibenzylcadaverine (DBC) also induced cytotoxicity at a similar concentration, while N1,N3-dibenzyl-1,3-diaminopropane (DBPr) was a much weaker inhibitor of cell growth [20].
• T. ishibashii also contained spermine, S. cruviseta contained norspermidine and norspermine and H. communis, F. candida and P. nipponicus contained diaminopropane, norspermidine and norspermine, as minor polyamines above the detection limit (0.01 micromol/g wet mass) [21].

Gene context of Dianol

• The administration of diaminopropane, an inhibitor of ornithine decarboxylase, has only limited effects on the activation of RNA synthesis by liver nuclei, which occurs 10 hr after turpentine treatment [22].
• An inhibitor of ODC synthesis, diaminopropane (DAP), and an irreversible inhibitor of ODC activity, alpha-DL-difluoromethylornithine (alpha-DFMO), each suppressed the FCS-stimulated ODC activity when added to the culture medium [23].
• Diaminopropane inhibits brain ornithine decarboxylase, but does not induce an ornithine decarboxylase-antizyme [24].
• After systematic optimization separation conditions were selected: 100 mM borate buffer at pH 8.5 with 0.4 mM diaminopropane as EOF modifier [25].
• For the production of efficient antibody diagnostics it is advisable to use amidol while in the case of highly active and concentrated sera, amidol, CrCl3 and glutaraldehyde should be employed [26].

Analytical, diagnostic and therapeutic context of Dianol

• Rats received weekly subcutaneous injections of AOM for 10 weeks and subcutaneous injections of VIP every other day and drinking water containing DAP (2.5 milligrams) ad libitum until the end of the experiment at week 45 [27].
• We have studied by autoradiography the effects of 1,3-diaminopropane (DAP) upon cellular proliferation in a number of tissues in vivo in the rat [16].

References