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Gene Review

Arhgef16  -  Rho guanine nucleotide exchange factor...

Mus musculus

Synonyms: Ephexin-4, Neuroblastoma, Rho guanine nucleotide exchange factor 16
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Disease relevance of Arhgef16


Psychiatry related information on Arhgef16

  • Treatment with r-interferon gamma or rIL-2 on days 1 through 3 after C1300-NRB inoculation significantly prolonged the mean tumor latency period, decreased the tumor growth rate, and enhanced in vitro NK killing of C1300-NRB and YAC-1 [6].
  • Two (P117L; M146L) familial Alzheimer's disease (FAD)-causing presenilin-1 (PS1) mutations have been tested fortheir effect in stably transfected mouse neuroblastoma (N2a) cell lines [7].
  • The following four parameters were considered: 1) dose of injected cells, 2) type of injected tumour (NB or T-L), 3) age of mice after individuation of three groups of animals (group A, 4-9 weeks old, group B, 9-20 weeks old, group C, > 20 weeks old), 4) injected cell line within the same tumour type [8].
  • Administrations of ABPP (200 mg/kg or 500 mg/kg) at intervals of 2 days and the injection of IFN (25,000 IU/mouse) 3 hr before each administration of ABPP to neuroblastoma-bearing A/J mice reduced the mortality and completely cured 40% of the mice in each combined therapy group [9].

High impact information on Arhgef16


Chemical compound and disease context of Arhgef16


Biological context of Arhgef16


Anatomical context of Arhgef16


Associations of Arhgef16 with chemical compounds


Physical interactions of Arhgef16


Enzymatic interactions of Arhgef16

  • Furthermore, the phosphopeptide patterns of brain MAP-1B phosphorylated in vitro by either purified casein kinase II or an extract obtained from differentiating neuroblastoma cells are identical to each other and similar to that of in vivo phosphorylated neuroblastoma MAP-1B [21].

Regulatory relationships of Arhgef16


Other interactions of Arhgef16

  • To define the nature of the "dominant negative" effect of the PS1 aspartate variants, we stably expressed PS1 harboring aspartate to alanine substitutions at codons 257 (D257A) or 385 (D385A), singly or in combination (D257A/D385A), in mouse neuroblastoma, N2a cells [40].
  • RESULTS: P10(4) exerted a potent cytotoxic activity on different neuroblastoma and melanoma cell lines through induction of both extrinsic and intrinsic caspase cascades and subsequent apoptosis [41].
  • Here we demonstrate that the early induction of apoptosis in a model of lyssavirus-infected neuroblastoma cells involves a TRAIL-dependent pathway requiring the activation of caspase-8 but not of caspase-9 or caspase-10 [42].
  • In our model, Fas ligand (CD95L) appears to play a limited role in lyssavirus-mediated neuroblastoma cell death [42].
  • To generalize this observation, we attempted to quantify AChE(R) and AChE(T) after organophosphate intoxication in the mouse brain and compared the observed effects with those of stress induced by swimming or immobilization; we also analyzed the effects of heat shock and AChE inhibition on neuroblastoma cells [43].

Analytical, diagnostic and therapeutic context of Arhgef16


  1. The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Murray, M.J., Cunningham, J.M., Parada, L.F., Dautry, F., Lebowitz, P., Weinberg, R.A. Cell (1983) [Pubmed]
  2. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas. Padhy, L.C., Shih, C., Cowing, D., Finkelstein, R., Weinberg, R.A. Cell (1982) [Pubmed]
  3. Muscarinic response to acetylcholine in neuroblastoma times glioma hybrid cells. Traber, J., Fischer, K., Buchen, C., Hamprecht, B. Nature (1975) [Pubmed]
  4. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Schwab, M., Alitalo, K., Klempnauer, K.H., Varmus, H.E., Bishop, J.M., Gilbert, F., Brodeur, G., Goldstein, M., Trent, J. Nature (1983) [Pubmed]
  5. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Levine, B., Huang, Q., Isaacs, J.T., Reed, J.C., Griffin, D.E., Hardwick, J.M. Nature (1993) [Pubmed]
  6. The influence of natural killer cells in neuroblastoma. Reynolds, J.V., Shou, J., Choi, H., Sigal, R., Ziegler, M.M., Daly, J.M. Archives of surgery (Chicago, Ill. : 1960) (1989) [Pubmed]
  7. Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations. Dowjat, W.K., Wisniewski, T., Efthimiopoulos, S., Wisniewski, H.M. Neurosci. Lett. (1999) [Pubmed]
  8. Animal age-, dose- and cell line-dependent growth of human neuroblastoma in nude mice. A statistical analysis. Mariottini, G.L., Montaldo, P.G., Copello, F. Riv. Biol. (2004) [Pubmed]
  9. Interferon counteracts pyrimidinone-induced hyporeactivity and the combined treatment has antitumor effect in mice. Oku, T., Imanishi, J., Kishida, T. Gann = Gan. (1984) [Pubmed]
  10. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Jordanova, A., Irobi, J., Thomas, F.P., Van Dijck, P., Meerschaert, K., Dewil, M., Dierick, I., Jacobs, A., De Vriendt, E., Guergueltcheva, V., Rao, C.V., Tournev, I., Gondim, F.A., D'Hooghe, M., Van Gerwen, V., Callaerts, P., Van Den Bosch, L., Timmermans, J.P., Robberecht, W., Gettemans, J., Thevelein, J.M., De Jonghe, P., Kremensky, I., Timmerman, V. Nat. Genet. (2006) [Pubmed]
  11. Neurofibromatosis type 1 gene mutations in neuroblastoma. The, I., Murthy, A.E., Hannigan, G.E., Jacoby, L.B., Menon, A.G., Gusella, J.F., Bernards, A. Nat. Genet. (1993) [Pubmed]
  12. Isolation of a transforming sequence from a human bladder carcinoma cell line. Shih, C., Weinberg, R.A. Cell (1982) [Pubmed]
  13. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Lasorella, A., Noseda, M., Beyna, M., Yokota, Y., Iavarone, A. Nature (2000) [Pubmed]
  14. Morphine elevates levels of cyclic GMP in a neuroblastoma X glioma hybrid cell line. Gullis, R., Traber, J., Hamprecht, B. Nature (1975) [Pubmed]
  15. Morphine antagonises action of prostaglandin in neuroblastoma and neuroblastoma times glioma hybrid cells. Traber, J., Fischer, K., Latzin, S., Hamprecht, B. Nature (1975) [Pubmed]
  16. Ethanol modulation of opiate receptors in cultured neural cells. Charness, M.E., Gordon, A.S., Diamond, I. Science (1983) [Pubmed]
  17. Renin and angiotensin: the complete system within the neuroblastoma x glioma cell. Fishman, M.C., Zimmerman, E.A., Slater, E.E. Science (1981) [Pubmed]
  18. Targeted enhancement of the biological activity of the antineoplastic agent, neocarzinostatin. Studies in murine neuroblastoma cells. Schor, N.F. J. Clin. Invest. (1992) [Pubmed]
  19. Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Maltese, W.A., Defendini, R., Green, R.A., Sheridan, K.M., Donley, D.K. J. Clin. Invest. (1985) [Pubmed]
  20. DR-nm23 gene expression in neuroblastoma cells: relationship to integrin expression, adhesion characteristics, and differentiation. Amendola, R., Martinez, R., Negroni, A., Venturelli, D., Tanno, B., Calabretta, B., Raschellà, G. J. Natl. Cancer Inst. (1997) [Pubmed]
  21. A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation. Díaz-Nido, J., Serrano, L., Méndez, E., Avila, J. J. Cell Biol. (1988) [Pubmed]
  22. Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene. Drebin, J.A., Stern, D.F., Link, V.C., Weinberg, R.A., Greene, M.I. Nature (1984) [Pubmed]
  23. Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells. Ishii, D.N., Fibach, E., Yamasaki, H., Weinstein, I.B. Science (1978) [Pubmed]
  24. Amiloride selectively blocks the low threshold (T) calcium channel. Tang, C.M., Presser, F., Morad, M. Science (1988) [Pubmed]
  25. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Maricq, A.V., Peterson, A.S., Brake, A.J., Myers, R.M., Julius, D. Science (1991) [Pubmed]
  26. Synapse formation between two clonal cell lines. Christian, C.N., Nelson, P.G., Peacock, J., Nirenberg, M. Science (1977) [Pubmed]
  27. Enhancement of the electrical excitability of neuroblastoma cells by valinomycin. Spector, I., Palfrey, C., Littauer, U.Z. Nature (1975) [Pubmed]
  28. L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment. Wick, M.M. Science (1978) [Pubmed]
  29. Complete tumor ablation with iodine 131-radiolabeled disialoganglioside GD2-specific monoclonal antibody against human neuroblastoma xenografted in nude mice. Cheung, N.K., Landmeier, B., Neely, J., Nelson, A.D., Abramowsky, C., Ellery, S., Adams, R.B., Miraldi, F. J. Natl. Cancer Inst. (1986) [Pubmed]
  30. Desensitization of neurotensin receptor-mediated cyclic GMP formation in neuroblastoma clone N1E-115. Gilbert, J.A., Strobel, T.R., Richelson, E. Biochem. Pharmacol. (1988) [Pubmed]
  31. Effects of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells. Chen, K.Y., Nau, D., Liu, A.Y. Cancer Res. (1983) [Pubmed]
  32. Chronic activation of inhibitory delta-opioid receptors cross-regulates the stimulatory adenylate cyclase-coupled prostaglandin E1 receptor system in neuroblastoma x glioma (NG108-15) hybrid cells. Ammer, H., Schulz, R. J. Neurochem. (1995) [Pubmed]
  33. Coupling of m2 and m4 muscarinic acetylcholine receptor subtypes to Ca(2+)-dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells. Noda, M., Katayama, M., Brown, D.A., Robbins, J., Marsh, S.J., Ishizaka, N., Fukuda, K., Hoshi, N., Yokoyama, S., Higashida, H. Proc. Biol. Sci. (1993) [Pubmed]
  34. Allogeneic class I major histocompatibility complex gene transfer in murine neuroblastoma in vivo. Ishida, H., Kaneda, Y., Yamane, S., Sawada, T., Plautz, G.E., Matsumura, T. Anticancer Res. (1999) [Pubmed]
  35. The RB-related gene Rb2/p130 in neuroblastoma differentiation and in B-myb promoter down-regulation. Raschellà, G., Tanno, B., Bonetto, F., Negroni, A., Claudio, P.P., Baldi, A., Amendola, R., Calabretta, B., Giordano, A., Paggi, M.G. Cell Death Differ. (1998) [Pubmed]
  36. Genomewide analysis of gene expression associated with Tcof1 in mouse neuroblastoma. Mogass, M., York, T.P., Li, L., Rujirabanjerd, S., Shiang, R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  37. Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Zhou, Q.L., Strichartz, G., Davar, G. Neuroreport (2001) [Pubmed]
  38. Role of signal transduction systems in neurotensin receptor down-regulation induced by agonist in murine neuroblastoma clone N1E-115 cells. Yamada, M., Yamada, M., Richelson, E. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  39. Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. Fan, S., Ramirez, S.H., Garcia, T.M., Dewhurst, S. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  40. Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein. Kim, S.H., Leem, J.Y., Lah, J.J., Slunt, H.H., Levey, A.I., Thinakaran, G., Sisodia, S.S. J. Biol. Chem. (2001) [Pubmed]
  41. In vitro and in vivo antitumor activity of the novel derivatized polyvinyl alcohol-based polymer P10(4). Raffaghello, L., Zuccari, G., Carosio, R., Orienti, I., Montaldo, P.G. Clin. Cancer Res. (2006) [Pubmed]
  42. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. Kassis, R., Larrous, F., Estaquier, J., Bourhy, H. J. Virol. (2004) [Pubmed]
  43. The readthrough variant of acetylcholinesterase remains very minor after heat shock, organophosphate inhibition and stress, in cell culture and in vivo. Perrier, N.A., Salani, M., Falasca, C., Bon, S., Augusti-Tocco, G., Massoulié, J. J. Neurochem. (2005) [Pubmed]
  44. Three-dimensional chromatin distribution in neuroblastoma nuclei shown by confocal scanning laser microscopy. Brakenhoff, G.J., van der Voort, H.T., van Spronsen, E.A., Linnemans, W.A., Nanninga, N. Nature (1985) [Pubmed]
  45. Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts. Zamboni, W.C., Stewart, C.F., Thompson, J., Santana, V.M., Cheshire, P.J., Richmond, L.B., Luo, X., Poquette, C., Houghton, J.A., Houghton, P.J. J. Natl. Cancer Inst. (1998) [Pubmed]
  46. Targeted interleukin-2 therapy for spontaneous neuroblastoma metastases to bone marrow. Lode, H.N., Xiang, R., Varki, N.M., Dolman, C.S., Gillies, S.D., Reisfeld, R.A. J. Natl. Cancer Inst. (1997) [Pubmed]
  47. Tubulin constancy during morphological differentiation of mouse neuroblastoma cells. Morgan, J.L., Seeds, N.W. J. Cell Biol. (1975) [Pubmed]
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