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Ghoneim, M.A. et al.

Endothelium localization of ETB receptor revealed by immunohistochemistry.

The ETB receptor has been found to be predominantly expressed in the vascular endothelium of various bovine tissues by immunostaining with a highly specific antiserum that does not cross-react with ETA. The tissues examined include the lung, trachea, kidney, adrenal gland, pituitary gland, and cerebellum. The wide-spread localization of ETB in the endothelial lining suggests that there is an ETB- mediated autocrine system of endothelin, which plays an important role in regulation of the functions of endothelial cells.[1]

References

Endothelium localization of ETB receptor revealed by immunohistochemistry. Ghoneim, M.A., Yamamoto, T., Hirose, S., Nagasawa, T., Hagiwara, H. J. Cardiovasc. Pharmacol. (1993) [Pubmed]

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