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Gene Review

EDN1  -  endothelin 1

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Disease relevance of EDN1


Psychiatry related information on EDN1


High impact information on EDN1


Chemical compound and disease context of EDN1


Biological context of EDN1


Anatomical context of EDN1


Associations of EDN1 with chemical compounds


Enzymatic interactions of EDN1

  • This study shows that both PPAR-alpha (Wy 14643) and PPAR-gamma activation (rosiglitazone) partially inhibit oxidized LDL-induced protein kinase C activity and endothelin-1 secretion in endothelial cells at the transcriptional levels and suggests that synthetic PPAR activators are stronger PPAR activators than oxidized LDL [25].

Regulatory relationships of EDN1


Other interactions of EDN1

  • EC cocultured with concanavalin A-activated PBMC (ActPBMC) increased CCL2 secretion an average of 12-fold higher compared with controls (P < 0.05), but again, EDN1 secretion was unchanged (P > 0.05) [23].
  • Thus, we investigated the local secretion of PGF(2alpha), ET-1, and Ang II in the corpus luteum (CL) and their real-time relationships during spontaneous luteolysis in the cow [16].
  • These findings suggest that the vasodilating property of parathyroid hormone-related protein may be mediated in part through its inhibitory effect on endothelin-1 production, which is probably mediated through nitric oxide and cGMP in endothelial cells [28].
  • It is concluded that arginine vasopressin and angiotensin II stimulate the release of endothelin-1 by a common mechanism, involving receptor-mediated mobilization of intracellular Ca2+ and activation of protein kinase C in endothelial cells [30].
  • The effects of tumor necrosis factor-alpha (TNF-alpha) on the production of the vasoactive substances nitric oxide (NO) and endothelin-1 (ET-1) were investigated in cerebrovascular cells in culture [31].

Analytical, diagnostic and therapeutic context of EDN1


  1. Endothelin-1 synthesis reduced by red wine. Corder, R., Douthwaite, J.A., Lees, D.M., Khan, N.Q., Viseu Dos Santos, A.C., Wood, E.G., Carrier, M.J. Nature (2001) [Pubmed]
  2. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Delerive, P., Martin-Nizard, F., Chinetti, G., Trottein, F., Fruchart, J.C., Najib, J., Duriez, P., Staels, B. Circ. Res. (1999) [Pubmed]
  3. Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1. Davie, N.J., Gerasimovskaya, E.V., Hofmeister, S.E., Richman, A.P., Jones, P.L., Reeves, J.T., Stenmark, K.R. Am. J. Pathol. (2006) [Pubmed]
  4. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Park, J.Y., Takahara, N., Gabriele, A., Chou, E., Naruse, K., Suzuma, K., Yamauchi, T., Ha, S.W., Meier, M., Rhodes, C.J., King, G.L. Diabetes (2000) [Pubmed]
  5. Characterization of endothelin receptors and effects of endothelin on diacylglycerol and protein kinase C in retinal capillary pericytes. Lee, T.S., Hu, K.Q., Chao, T., King, G.L. Diabetes (1989) [Pubmed]
  6. Angiotensin II interacts with prostaglandin F2alpha and endothelin-1 as a local luteolytic factor in the bovine corpus luteum in vitro. Hayashi, K., Miyamoto, A. Biol. Reprod. (1999) [Pubmed]
  7. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D., Yanagisawa, M. Cell (1994) [Pubmed]
  8. Verotoxin and ricin have novel effects on preproendothelin-1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium. Bitzan, M.M., Wang, Y., Lin, J., Marsden, P.A. J. Clin. Invest. (1998) [Pubmed]
  9. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. Hernández-Perera, O., Pérez-Sala, D., Navarro-Antolín, J., Sánchez-Pascuala, R., Hernández, G., Díaz, C., Lamas, S. J. Clin. Invest. (1998) [Pubmed]
  10. Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. Malarkey, K., Chilvers, E.R., Lawson, M.F., Plevin, R. Br. J. Pharmacol. (1995) [Pubmed]
  11. Mechanical stress eliminates the effects of plasma from patients with preeclampsia on endothelial cells. Baker, P.N., Stranko, C.P., Davidge, S.T., Davies, P.S., Roberts, J.M. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  12. Hypoxia increases endothelin release in bovine endothelial cells in culture, but epinephrine, norepinephrine, serotonin, histamine and angiotensin II do not. Hieda, H.S., Gomez-Sanchez, C.E. Life Sci. (1990) [Pubmed]
  13. Effects of nitric oxide donors and nitric oxide synthase substrates on ciliary muscle contracted by carbachol and endothelin for possible use in myopia prevention. Beauregard, C., Liu, Q., Chiou, G.C. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2001) [Pubmed]
  14. Nucleotide sequence of endothelin cDNA from bovine endothelial cells. Elshourbagy, N.A., Kmetz, P., Sathe, G.M. Nucleic Acids Res. (1990) [Pubmed]
  15. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Imai, T., Hirata, Y., Emori, T., Yanagisawa, M., Masaki, T., Marumo, F. Hypertension (1992) [Pubmed]
  16. Real-time relationships in intraluteal release among Prostaglandin F2alpha, endothelin-1, and angiotensin II during spontaneous luteolysis in the cow. Shirasuna, K., Asaoka, H., Acosta, T.J., Wijayagunawardane, M.P., Ohtani, M., Hayashi, M., Matsui, M., Miyamoto, A. Biol. Reprod. (2004) [Pubmed]
  17. Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Malek, A.M., Greene, A.L., Izumo, S. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  18. Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. Collado, M.P., Latorre, E., Fernández, I., Aragonés, M.D., Catalán, R.E. Microvasc. Res. (2003) [Pubmed]
  19. High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. Hu, R.M., Chuang, M.Y., Prins, B., Kashyap, M.L., Frank, H.J., Pedram, A., Levin, E.R. J. Clin. Invest. (1994) [Pubmed]
  20. Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart. López Farré, A., Riesco, A., Espinosa, G., Digiuni, E., Cernadas, M.R., Alvarez, V., Montón, M., Rivas, F., Gallego, M.J., Egido, J. Circulation (1993) [Pubmed]
  21. The endothelin-converting enzyme from human umbilical vein is a membrane-bound metalloprotease similar to that from bovine aortic endothelial cells. Ahn, K., Beningo, K., Olds, G., Hupe, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells. Harrison, V.J., Barnes, K., Turner, A.J., Wood, E., Corder, R., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  23. Cooperative expression of monocyte chemoattractant protein 1 within the bovine corpus luteum: evidence of immune cell-endothelial cell interactions in a coculture system. Liptak, A.R., Sullivan, B.T., Henkes, L.E., Wijayagunawardane, M.P., Miyamoto, A., Davis, J.S., Rueda, B.R., Townson, D.H. Biol. Reprod. (2005) [Pubmed]
  24. Homocysteine-induced endothelin-1 release is dependent on hyperglycaemia and reactive oxygen species production in bovine aortic endothelial cells. Sethi, A.S., Lees, D.M., Douthwaite, J.A., Dawnay, A.B., Corder, R. J. Vasc. Res. (2006) [Pubmed]
  25. Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells. Martin-Nizard, F., Furman, C., Delerive, P., Kandoussi, A., Fruchart, J.C., Staels, B., Duriez, P. J. Cardiovasc. Pharmacol. (2002) [Pubmed]
  26. Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor. Hu, R.M., Levin, E.R., Pedram, A., Frank, H.J. J. Biol. Chem. (1992) [Pubmed]
  27. Dehydroepiandrosterone Mimics Acute Actions of Insulin to Stimulate Production of Both Nitric Oxide and Endothelin 1 via Distinct Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Dependent Pathways in Vascular Endothelium. Formoso, G., Chen, H., Kim, J.A., Montagnani, M., Consoli, A., Quon, M.J. Mol. Endocrinol. (2006) [Pubmed]
  28. Parathyroid hormone-related protein inhibits indothelin-1 production. Jiang, B., Morimoto, S., Fukuo, K., Hirotani, A., Tamatani, M., Nakahashi, T., Nishibe, A., Niinobu, T., Hata, S., Chen, S., Ogihara, T. Hypertension (1996) [Pubmed]
  29. Inhibitory effect of adrenomedullin on basal and tumour necrosis factor alpha-stimulated endothelin-1 synthesis in bovine aortic endothelial cells is independent of cyclic AMP. Barker, S., Lees, D.M., Wood, E.G., Corder, R. Biochem. Pharmacol. (2002) [Pubmed]
  30. Cellular mechanism of endothelin-1 release by angiotensin and vasopressin. Emori, T., Hirata, Y., Ohta, K., Kanno, K., Eguchi, S., Imai, T., Shichiri, M., Marumo, F. Hypertension (1991) [Pubmed]
  31. Effects of TNF-alpha on the production of vasoactive substances by cerebral endothelial and smooth muscle cells in culture. Estrada, C., Gómez, C., Martín, C. J. Cereb. Blood Flow Metab. (1995) [Pubmed]
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