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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Possible involvement of peripheral-type benzodiazepine receptors in erythroid differentiation of human leukemia cell line, K562.

Possible involvement of the peripheral-type benzodiazepine receptor ( PBR) in hemin/protoporphyrin- induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diazepam and PK11195. Diazepam itself exhibited differentiation-inducing activity on K562 cells. The PBR-specific antagonist, PK11195, dose-dependently inhibited both diazepam-induced and hemin/protoporphyrin-induced K562 cell differentiation. The results imply that PBR is involved in the erythroid differentiation of K562 cells.[1]


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