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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The extracts from rat submandibular glands induce the erythroid differentiation of K-562 cells.

The extracts from rat submandibular glands (SMGs) induced erythroid differentiation of K-562. The activity was non-dialysable and abolished by heat, trypsin or 2-mercaptoethanol. Follistatin, which neutralizes the erythroid differentiation factor ( EDF), had no effects on this activity. Analysis by gel chromatography and polyacrylamide gel electrophoresis-isoelectric focussing showed that the characteristics of this substance were different from those of erythropoietin, TGF-beta 1, EDF, stem cell factor and insulin-like growth factor-1. These results suggest the presence of a novel substance in rat SMGs which induces erythroid differentiation of K-562.[1]

References

  1. The extracts from rat submandibular glands induce the erythroid differentiation of K-562 cells. Sasaki, R., Masuyama, A., Etoh, Y., Yoshida, H., Miura, Y., Sasaki, H. Leuk. Res. (1995) [Pubmed]
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