The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Homodimeric association of the spike glycoproteins G1 and G2 of Uukuniemi virus.

We have studied the interactions of the G1 and G2 membrane glycoproteins of Uukuniemi virus, a bunyavirus, in virus particles and in Triton X-100-solubilized virus. The G1 glycoprotein in intact virus or in Triton solution could be oxidized into a covalent homodimer using Cu2+ ion as a catalyst. Immunoprecipitations of the glycoproteins from Triton-solubilized virus lysates showed that G1 and G2 do not form a stable heterodimeric or heterooligomeric complex. The oligomeric association of G1 and G2 was further analyzed using centrifugation in sucrose gradients in the presence of Triton X-100. The results indicate that G1 exists as a Triton-resistant pH-insensitive homodimer. This is in contrast to the behavior of G2, which exists as a homodimer and partially as a monomer at pH 6.4 or above and is dissociated completely into a monomer at pH 6.0 or below. The threshold for the dimer-monomer shift of G2 is between pH 6.2 and pH 6. 0. Electron microscopy studies show that the surface structure of the virus particle undergoes a pH-dependent change. Studies on the kinetics of virus entry suggest that pH below 6.2 is necessary for the penetration of Uukuniemi virus.[1]


  1. Homodimeric association of the spike glycoproteins G1 and G2 of Uukuniemi virus. Rönkä, H., Hildén, P., Von Bonsdorff, C.H., Kuismanen, E. Virology (1995) [Pubmed]
WikiGenes - Universities