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MeSH Review

Orthobunyavirus

 
 
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Disease relevance of Orthobunyavirus

 

High impact information on Orthobunyavirus

  • We have previously shown that the IFN-induced human MxA protein inhibits bunyavirus replication by an unknown mechanism [6].
  • These results suggest that, although not essential for growth in tissue culture or in mice, the bunyavirus NSs protein has several functions in the virus life cycle and contributes to viral pathogenesis [7].
  • Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis [7].
  • Independent of caspase activation, Bunyavirus NSs proteins also share with Reaper the ability to directly inhibit cellular protein translation [8].
  • A signal for Golgi retention in the bunyavirus G1 glycoprotein [9].
 

Chemical compound and disease context of Orthobunyavirus

  • Comparisons with the published sequences of the related snowshoe hare bunyavirus S RNA and its gene products (Bishop et al., Nucleic Acids Res. 10:3703-3713, 1982) indicate that there are a total of 114 nucleotide differences (6 additions or deletions and 108 substitutions) [10].
  • The complementary termini and a purine-rich sequence in the 3' non-coding region (genome-complementary sense) were highly conserved amongst CAL serogroup bunyavirus S RNAs [11].
  • With the aim of isolating temperature-sensitive (ts) mutants defective in virus maturation or glycoprotein transport, Uukuniemi virus, a bunyavirus, was mutagenized with N-methyl-N'-nitro-N-nitrosoguanidine [12].
  • Infection of Vero (monkey) cells by Germiston bunyavirus is highly cytopathic with cell lysis and virus production at a high titre, whereas infection of Aedes albopictus C6/36 (mosquito) cells leads, after an acute primary phase, to a persistent non-cytopathic infection with a loss in virus production [13].
  • A single prophylactic i.p. dose of ampligen 1 day before virus challenge was very effective against Banzi virus, moderately effective against HSV-2, and ineffective against VEE and Caraparu (a bunyavirus) infection [14].
 

Biological context of Orthobunyavirus

  • An MP-12 mutant carrying a luciferase gene in place of the NSs gene replicated as efficiently as MP-12 did, produced enzymatically active luciferase during replication, and stably retained the luciferase gene after 10 virus passages, representing the first demonstration of foreign gene expression in any bunyavirus [15].
  • The bunyavirus nucleocapsid protein is an RNA chaperone: possible roles in viral RNA panhandle formation and genome replication [16].
  • Significant sequence homology was found between the G1 glycoproteins of members of the genus Bunyavirus and a corresponding region in the glycoprotein precursor of TSWV, indicating a close evolutionary relationship between these viruses [17].
  • Antigenic sites on the G1 glycoprotein of La Crosse bunyavirus were defined by constructing a panel of neutralizing and nonneutralizing monoclonal antibodies (F. Gonzalez-Scarano, R. E. Shope, C. H. Calisher, and N. Nathanson (1982), Virology 120, 42-53) [18].
  • Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product [19].
 

Gene context of Orthobunyavirus

  • A six-way alignment of the amino acid sequences of the N and NSs proteins of viruses representing three serogroups within the Bunyavirus genus indicates regions which are strongly conserved, and provides targets for future analysis of protein function [20].
  • Thus, phylogenetic analysis of the AKA virus N protein gene gives a greater insight into bunyavirus evolution [21].
  • An avirulent G1 glycoprotein variant of La Crosse bunyavirus with defective fusion function [22].
  • A transcript from the S segment of the Germiston bunyavirus is uncapped and codes for the nucleoprotein and a nonstructural protein [23].
  • Hence the initiation of mRNA transcription by the recombinant L protein resembles that seen during authentic bunyavirus infection and suggests that the L protein has the endonuclease activity which generates the primers [24].
 

Analytical, diagnostic and therapeutic context of Orthobunyavirus

References

  1. Rift valley fever virus nonstructural protein NSs promotes viral RNA replication and transcription in a minigenome system. Ikegami, T., Peters, C.J., Makino, S. J. Virol. (2005) [Pubmed]
  2. Identification of nonstructural proteins encoded by viruses of the Bunyamwera serogroup (family Bunyaviridae). Elliott, R.M. Virology (1985) [Pubmed]
  3. Homodimeric association of the spike glycoproteins G1 and G2 of Uukuniemi virus. Rönkä, H., Hildén, P., Von Bonsdorff, C.H., Kuismanen, E. Virology (1995) [Pubmed]
  4. Classification of Barmah Forest virus as an alphavirus using cytotoxic T cell assays. Müllbacher, A., Marshall, I.D., Ferris, P. J. Gen. Virol. (1986) [Pubmed]
  5. Analysis of the intracellular transport properties of recombinant La Crosse virus glycoproteins. Bupp, K., Stillmock, K., González-Scarano, F. Virology (1996) [Pubmed]
  6. Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Kochs, G., Janzen, C., Hohenberg, H., Haller, O. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis. Bridgen, A., Weber, F., Fazakerley, J.K., Elliott, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Colón-Ramos, D.A., Irusta, P.M., Gan, E.C., Olson, M.R., Song, J., Morimoto, R.I., Elliott, R.M., Lombard, M., Hollingsworth, R., Hardwick, J.M., Smith, G.K., Kornbluth, S. Mol. Biol. Cell (2003) [Pubmed]
  9. A signal for Golgi retention in the bunyavirus G1 glycoprotein. Matsuoka, Y., Chen, S.Y., Compans, R.W. J. Biol. Chem. (1994) [Pubmed]
  10. Comparison of the sequences and coding of La Crosse and snowshoe hare bunyavirus S RNA species. Akashi, H., Bishop, D.H. J. Virol. (1983) [Pubmed]
  11. Determination and comparative analysis of the small RNA genomic sequences of California encephalitis, Jamestown Canyon, Jerry Slough, Melao, Keystone and Trivittatus viruses (Bunyaviridae, genus Bunyavirus, California serogroup). Bowen, M.D., Jackson, A.O., Bruns, T.D., Hacker, D.L., Hardy, J.L. J. Gen. Virol. (1995) [Pubmed]
  12. Characterization of two recombination-complementation groups of Uukuniemi virus temperature-sensitive mutants. Gahmberg, N. J. Gen. Virol. (1984) [Pubmed]
  13. Quantitative in situ hybridization using strand specific RNA probes: expression of the bunyavirus Germiston S segment in mosquito cells. Delord, B., Poveda, J.D., Astier-Gin, T., Gerbaud, S., Wattiaux, J.P., Fleury, H.J. Mol. Cell. Probes (1990) [Pubmed]
  14. Comparative study of various immunomodulators for macrophage and natural killer cell activation and antiviral efficacy against exotic RNA viruses. Pinto, A.J., Morahan, P.S., Brinton, M.A. Int. J. Immunopharmacol. (1988) [Pubmed]
  15. Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign gene. Ikegami, T., Won, S., Peters, C.J., Makino, S. J. Virol. (2006) [Pubmed]
  16. The bunyavirus nucleocapsid protein is an RNA chaperone: possible roles in viral RNA panhandle formation and genome replication. Mir, M.A., Panganiban, A.T. RNA (2006) [Pubmed]
  17. The nucleotide sequence of the M RNA segment of tomato spotted wilt virus, a bunyavirus with two ambisense RNA segments. Kormelink, R., de Haan, P., Meurs, C., Peters, D., Goldbach, R. J. Gen. Virol. (1992) [Pubmed]
  18. Epitopes of the G1 glycoprotein of La Crosse virus form overlapping clusters within a single antigenic site. Najjar, J.A., Gentsch, J.R., Nathanson, N., Gonzalez-Scarano, F. Virology (1985) [Pubmed]
  19. Nucleotide sequence of the Bunyamwera virus M RNA segment: conservation of structural features in the Bunyavirus glycoprotein gene product. Lees, J.F., Pringle, C.R., Elliott, R.M. Virology (1986) [Pubmed]
  20. Nucleotide sequence analysis of the small (S) RNA segment of Bunyamwera virus, the prototype of the family Bunyaviridae. Elliott, R.M. J. Gen. Virol. (1989) [Pubmed]
  21. Sequence determination and phylogenetic analysis of the Akabane bunyavirus S RNA genome segment. Akashi, H., Kaku, Y., Kong, X.G., Pang, H. J. Gen. Virol. (1997) [Pubmed]
  22. An avirulent G1 glycoprotein variant of La Crosse bunyavirus with defective fusion function. Gonzalez-Scarano, F., Janssen, R.S., Najjar, J.A., Pobjecky, N., Nathanson, N. J. Virol. (1985) [Pubmed]
  23. A transcript from the S segment of the Germiston bunyavirus is uncapped and codes for the nucleoprotein and a nonstructural protein. Bouloy, M., Vialat, P., Girard, M., Pardigon, N. J. Virol. (1984) [Pubmed]
  24. Characterization of Bunyamwera virus S RNA that is transcribed and replicated by the L protein expressed from recombinant vaccinia virus. Jin, H., Elliott, R.M. J. Virol. (1993) [Pubmed]
  25. Homotypic interaction of Bunyamwera virus nucleocapsid protein. Leonard, V.H., Kohl, A., Osborne, J.C., McLees, A., Elliott, R.M. J. Virol. (2005) [Pubmed]
  26. Isolation of Batai virus (Bunyaviridae:Bunyavirus) from the blood of suspected malaria patients in Sudan. Nashed, N.W., Olson, J.G., el-Tigani, A. Am. J. Trop. Med. Hyg. (1993) [Pubmed]
  27. Detection of the bunyavirus Germiston in VERO and Aedes albopictus C6/36 cells by in situ hybridization using cDNA and asymmetric RNA probes. Delord, B., Poveda, J.D., Astier-Gin, T., Gerbaud, S., Fleury, H.J. J. Virol. Methods (1989) [Pubmed]
 
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