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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

ClC family in the kidney.

PCR cloning strategy was used to isolate cDNAs of ClC family members in the kidney. Three new members, named ClC-K1, ClC-K2, ClC-3, have been isolated. Functional expression studies in the Xenopus oocytes confirmed that these are chloride channel proteins. Northern blot and immunohistochemistry showed that ClC-K1 and ClC-K2 are selectively expressed in the kidney, while ClC-3 distributes in a variety of organs such as brain, lung, and kidney. Identification and characterization of new ClC channel proteins will contribute to a better understanding of chloride transport in the kidney.[1]


  1. ClC family in the kidney. Sasaki, S., Uchida, S., Kawasaki, M., Adachi, S., Marumo, F. Jpn. J. Physiol. (1994) [Pubmed]
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