ClC family in the kidney.
PCR cloning strategy was used to isolate cDNAs of ClC family members in the kidney. Three new members, named ClC-K1, ClC-K2, ClC-3, have been isolated. Functional expression studies in the Xenopus oocytes confirmed that these are chloride channel proteins. Northern blot and immunohistochemistry showed that ClC-K1 and ClC-K2 are selectively expressed in the kidney, while ClC-3 distributes in a variety of organs such as brain, lung, and kidney. Identification and characterization of new ClC channel proteins will contribute to a better understanding of chloride transport in the kidney.[1]References
- ClC family in the kidney. Sasaki, S., Uchida, S., Kawasaki, M., Adachi, S., Marumo, F. Jpn. J. Physiol. (1994) [Pubmed]
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