Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Kieback, D.G. et al.

Chicken ovalbumin upstream promoter transcription factor (COUP-TF): an orphan steroid receptor with a specific pattern of differential expression in human ovarian cancer cell lines.

The possible role of a novel steroid receptor in ovarian malignancy was investigated. The evolutionarily conserved orphan steroid receptor COUP-TF (chicken ovalbumin upstream promoter transcription factor) was originally identified as a protein interacting with an upstream promoter element of the chicken ovalbumin gene. The human receptor protein was purified from a cervical cancer cell line. An immunocytochemical technique for the visualization of COUP-TF was developed using a specific polyclonal rabbit antibody. Four established ovarian cancer cell lines were evaluated. The patterns of COUP-TF expression were compared to the staining intensities of immunocytochemical assays for estrogen receptor (ER), androgen receptor (AR), aromatase, and HER2/neu. A comparison of the ovarian cancer cell lines showed differential expression of COUP-TF in the nucleus. The pattern of COUP-TF expression did not follow the profile of any of the other four variables. In agreement with transfection experiments showing reduction of activity of other steroid receptors by elevated COUP-TF levels, high COUP-TF expression correlated with low ER activity also in native ovarian cancer cells. These data represent the first reported evidence that COUP-TF-like proteins may play a role in the metabolism and possibly in the process of dedifferentiation of human ovarian cancer.[1]

References

Chicken ovalbumin upstream promoter transcription factor (COUP-TF): an orphan steroid receptor with a specific pattern of differential expression in human ovarian cancer cell lines. Kieback, D.G., Runnebaum, I.B., Moebus, V.J., Kreienberg, R., McCamant, S.K., Edwards, C.L., Jones, L.A., Tsai, M.J., O'Malley, B.W. Gynecol. Oncol. (1993) [Pubmed]

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