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Gene Review

OVAL  -  ovalbumin (SERPINB14)

Gallus gallus

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Disease relevance of LOC396058


Psychiatry related information on LOC396058

  • Ovalbumin subfractionation and individual difference in ovalbumin microheterogeneity [6].
  • In the ovalbumin control locus up to the 6 kb upstream region, CpG sites were methylated in immature chickens, except for several sites, and almost all CpGs residing in DNase I hypersensitive sites I, II, and III, but not IV, were selectively unmethylated in ovalbumin expressing chickens [7].

High impact information on LOC396058

  • Four TGACC half-palindromic motifs, separated from each other by more than 100 bp, are responsible for conferring estrogen inducibility either to the proximal ovalbumin gene promoter or to heterologous promoters [8].
  • The ovalbumin promoter half-palindromic ERE motif located close to the TATA box was required for the activity of the distal DH3 ERE, but could be replaced by the binding sites of other transactivators [8].
  • A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5'-TGACC-3' motifs acting synergistically [8].
  • We have identified an estrogen-responsive enhancer element (DH3 ERE) in the estrogen-induced DNAase I-hypersensitive region III of the chicken ovalbumin gene, which is located approximately 3.3 kb upstream from the mRNA start site and does not contain palindromic ERE [8].
  • The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells [9].

Chemical compound and disease context of LOC396058


Biological context of LOC396058


Anatomical context of LOC396058

  • Ovalbumin mRNA was translated in a reticulocyte lysate [15].
  • Results of these experiments revealed that 50 to 60 amino acid residues are sufficient to bind ovalbumin-synthesizing polysomes to membranes in vitro [17].
  • Kinetic experiments were performed in a cell-free translation system to measure the minimum size of ovalbumin nascent chains required for binding of both the nascent chain and the corresponding mRNA to microsomal membranes derived from dog pancreas [17].
  • The observation that the transcriptionally active ovalbumin gene is preferentially associated with the nuclear matrix may have significant implications for gene expression and the organization of nuclear DNA into supercoiled-loop domains [9].
  • Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei [18].

Associations of LOC396058 with chemical compounds

  • These data indicate that induction of the ovalbumin gene by steroid hormones requires complex interactions involving both the SDRE and the negative regulatory element [16].
  • To characterize the regulatory properties of the SDRE more precisely, additional mutations were created in this region, and fusion genes prepared by linking the ovalbumin 5'-flanking region and promoter to the chloramphenicol acetyltransferase structural gene [16].
  • In contrast, I-ovalbumin, the product of a heating transition, is a potent reversible serine proteinase inhibitor [19].
  • We conclude that ovalbumin Y is a unique chimeric glycoprotein having an amino acid sequence similar to that of ovalbumin, but having a carbohydrate moiety similar to that of ovomucoid [20].
  • The overlap of the C-terminal sequence of this extended sequence with the six-residue N-terminal sequence surrounding a half-cystine residue in ovalbumin gives the N-terminal sequence for ovalbumin as acetyl-Gly-Ser-Ile-Gly-Ala-Ala-Ser-Met-Glu-Phe-Cys-Phe-Asp-Val-Phe-Lys with residue 11 a cysteine residue [21].

Physical interactions of LOC396058

  • We suggest that the interaction of a somatomedin with its membrane-bound receptor generates an intracellular signal that interacts specifically with the ovalbumin gene [22].
  • The purified DNA binding component (receptor A) of the chick oviduct progesterone receptor has been analyzed for its ability to bind to the cloned ovalbumin gene and to plasmid DNA of various structural compositions [23].
  • By means of the DNA-cellulose competitive binding assay, the interaction of estrogen receptor complexed to 17 beta-estradiol with fragments of a cloned DNA region of the estrogen responsive chicken ovalbumin gene spanning from 1343 bps upstream to 373 bps within the transcribed region of the gene (p0V 1.7) was investigated [24].
  • Disposable polypropylene plates were coated with specific IgG antibody and used for radioimmunoassay with 125I-specific IgG antibody to aldolase A. The non-specific binding was minimized by saturating the binding sites of the plates with 2% ovalbumin in 0.1% Tween 20 [25].
  • The results indicated that neither the NF1 binding element nor the ovalbumin upstream promoter showed any enhancer-like activity [26].

Enzymatic interactions of LOC396058

  • Rather, an analysis of the fragmentation of the ovalbumin chromatin as a function of digestion extent suggested a mechanism in which the heightened sensitivity resulted from the collective expansion of the nuclease cutting sites in the linker regions of the ovalbumin chromatin because the gene was in an unfolded conformation [27].

Regulatory relationships of LOC396058


Other interactions of LOC396058


Analytical, diagnostic and therapeutic context of LOC396058


  1. Steroid hormone dependence of four DNase I-hypersensitive regions located within the 7000-bp 5'-flanking segment of the ovalbumin gene. Kaye, J.S., Pratt-Kaye, S., Bellard, M., Dretzen, G., Bellard, F., Chambon, P. EMBO J. (1986) [Pubmed]
  2. Chicken ovalbumin is synthesized and secreted by Escherichia coli. Fraser, T.H., Bruce, B.J. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  3. Ovalbumin is synthesized in mouse cells transformed with the natural chicken ovalbumin gene. Lai, E.C., Woo, S.L., Bordelon-Riser, M.E., Fraser, T.H., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  4. A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter. Lee, M.O., Hobbs, P.D., Zhang, X.K., Dawson, M.I., Pfahl, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination. Rasmussen, I.B., Lunde, E., Michaelsen, T.E., Bogen, B., Sandlie, I. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Ovalbumin subfractionation and individual difference in ovalbumin microheterogeneity. Iwase, H., Kato, Y., Hotta, K. J. Biol. Chem. (1981) [Pubmed]
  7. Chicken ovalbumin promoter is demethylated upon expression in the regions specifically involved in estrogen-responsiveness. Morshed, M., Sano, S., Nishimiya, D., Ando, M., Nishijima, K., Iijima, S. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  8. A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5'-TGACC-3' motifs acting synergistically. Kato, S., Tora, L., Yamauchi, J., Masushige, S., Bellard, M., Chambon, P. Cell (1992) [Pubmed]
  9. The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells. Robinson, S.I., Nelkin, B.D., Vogelstein, B. Cell (1982) [Pubmed]
  10. Transfer of antigen-presenting capacity to Ia-negative cells upon fusion with Ia-bearing liposomes. Coeshott, C., Grey, H.M. J. Immunol. (1985) [Pubmed]
  11. Segregation of mutant ovalbumins and ovalbumin-globin fusion proteins in Xenopus oocytes. Identification of an ovalbumin signal sequence. Tabe, L., Krieg, P., Strachan, R., Jackson, D., Wallis, E., Colman, A. J. Mol. Biol. (1984) [Pubmed]
  12. Functional differences in protein synthesis between rat liver tRNA and tRNA from Novikoff hepatoma. Sharma, O.K., Mays, L.L., Borek, E. Biochemistry (1975) [Pubmed]
  13. The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene. Lai, E.C., Woo, S.L., Dugaiczyk, A., O'Malley, B.W. Cell (1979) [Pubmed]
  14. Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene. Catterall, J.F., O'Malley, B.W., Robertson, M.A., Staden, R., Tanaka, Y., Brownlee, G.G. Nature (1978) [Pubmed]
  15. Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. Palmiter, R.D., Gagnon, J., Walsh, K.A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  16. The steroid-dependent regulatory element in the ovalbumin gene does not function as a typical steroid response element. Schweers, L.A., Frank, D.E., Weigel, N.L., Sanders, M.M. J. Biol. Chem. (1990) [Pubmed]
  17. The signal sequence of ovalbumin is located near the NH2 terminus. Meek, R.L., Walsh, K.A., Palmiter, R.D. J. Biol. Chem. (1982) [Pubmed]
  18. Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei. Wickens, M.P., Woo, S., O'Malley, B.W., Gurdon, J.B. Nature (1980) [Pubmed]
  19. Kinetic and equilibrium characterization of the interaction between bovine trypsin and I-ovalbumin. Cuccioloni, M., Sparapani, L., Amici, M., Lupidi, G., Eleuteri, A.M., Angeletti, M. Biochim. Biophys. Acta (2004) [Pubmed]
  20. Ovalbumin-related gene Y protein bears carbohydrate chains of the ovomucoid type. Hirose, J., Doi, Y., Kitabatake, N., Narita, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  21. A correction and extension of the acetylated amino terminal sequence of ovalbumin. Thompson, E.O., Fisher, W.K. Aust. J. Biol. Sci. (1978) [Pubmed]
  22. A somatomedin-like peptide hormone is required during the estrogen-mediated induction of ovalbumin gene transcription. Evans, M.I., Hager, L.J., McKnight, G.S. Cell (1981) [Pubmed]
  23. Interaction of the chick oviduct progesterone receptor with deoxyribonucleic acid. Hughes, M.R., Compton, J.G., Schrader, W.T., O'Malley, B.W. Biochemistry (1981) [Pubmed]
  24. Specific binding of estrogen receptor to sites upstream and within the transcribed region of the chicken ovalbumin gene. Weisz, A., Coppola, L., Bresciani, F. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  25. A non-competitive solid-phase radioimmunoassay for human aldolase A. Asaka, M., Nagase, K., Miyazaki, T., Alpert, E. Clin. Chim. Acta (1982) [Pubmed]
  26. Modulation of transcriptional activity of the chicken ovalbumin gene promoter in primary cultures of chicken oviduct cells: effects of putative regulatory elements in the 5'-flanking region. Park, H.M., Okumura, J., Muramatsu, T. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  27. Hormonal regulation of the conformation of the ovalbumin gene in chick oviduct chromatin. Bloom, K.S., Anderson, J.N. J. Biol. Chem. (1982) [Pubmed]
  28. Peroxisome proliferator-activated receptor gamma and chicken ovalbumin upstream promoter transcription factor II negatively regulate the phosphoenolpyruvate carboxykinase promoter via a common element. Eubank, D.W., Duplus, E., Williams, S.C., Forest, C., Beale, E.G. J. Biol. Chem. (2001) [Pubmed]
  29. Stress fiber and cleavage furrow formation in living cells microinjected with fluorescently labeled alpha-actinin. Sanger, J.M., Mittal, B., Pochapin, M.B., Sanger, J.W. Cell Motil. Cytoskeleton (1987) [Pubmed]
  30. Estrogen receptor is not primarily responsible for altered responsiveness of ovalbumin mRNA induction in the oviduct from genetically selected high- and low-albumen chicken lines. Muramatsu, T., Hiramatsu, H., Park, H.M., Okumura, J., Kawashima, M., Miyoshi, S. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1997) [Pubmed]
  31. Inhibition of interferon-gamma production from lymphocytes stimulated with food antigens by a beta 2-agonist, procaterol, in patients with food-sensitive atopic dermatitis. Kondo, N., Shinbara, M., Inoue, R., Fukao, T., Kaneko, H., Teramoto, T., Tashita, H. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología. (1997) [Pubmed]
  32. Crystal structure of uncleaved ovalbumin at 1.95 A resolution. Stein, P.E., Leslie, A.G., Finch, J.T., Carrell, R.W. J. Mol. Biol. (1991) [Pubmed]
  33. cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta. Ye, R.D., Wun, T.C., Sadler, J.E. J. Biol. Chem. (1987) [Pubmed]
  34. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. Bernhisel-Broadbent, J., Dintzis, H.M., Dintzis, R.Z., Sampson, H.A. J. Allergy Clin. Immunol. (1994) [Pubmed]
  35. Distribution of estrogen and progesterone receptors and steroid-regulated gene products in the chick oviduct. Isola, J.J. Mol. Cell. Endocrinol. (1990) [Pubmed]
  36. Electron microscopy and restriction enzyme mapping reveal additional intervening sequences in the chicken ovalbumin split gene. Garapin, A.C., Cami, B., Roskam, W., Kourilsky, P., Le Pennec, J.P., Perrin, F., Gerlinger, P., Cochet, M., Chambon, P. Cell (1978) [Pubmed]
  37. Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors. Roop, D.R., Nordstrom, J.L., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Cell (1978) [Pubmed]
  38. The ovalbumin gene region: common features in the organisation of three genes expressed in chicken oviduct under hormonal control. Royal, A., Garapin, A., Cami, B., Perrin, F., Mandel, J.L., LeMeur, M., Brégégègre, F., Gannon, F., LePennec, J.P., Chambon, P., Kourilsky, P. Nature (1979) [Pubmed]
  39. The major histocompatibility complex-restricted antigen receptor on T cells. IV. An antiidiotypic antibody predicts both antigen and I-specificity. Marrack, P., Shimonkevitz, R., Hannum, C., Haskins, K., Kappler, J. J. Exp. Med. (1983) [Pubmed]
  40. The chicken ovalbumin promoter is under negative control which is relieved by steroid hormones. Gaub, M.P., Dierich, A., Astinotti, D., Touitou, I., Chambon, P. EMBO J. (1987) [Pubmed]
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