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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption.

An open reading frame, LMW8-DR, in the African swine fever virus (ASFV) genome possesses striking similarity to the lymphocyte membrane antigen CD2. All characterized CD2 domains, including the amino-terminal signal sequence, IgV, hinge, IgC2, stalk, transmembrane, and proline-rich carboxy cytoplasmic domains, are highly conserved in the ASFV gene. Critical residues for the binding of the lymphocyte function-associated antigen (LFA-3) and CD59 and for T-cell activation are also partially conserved. LMW8-DR is actively transcribed in ASFV-infected swine macrophages and Vero cells at late times in the infection cycle and Vero and COS cells transiently expressing the LMW8-DR open reading frame hemadsorbed swine red blood cells. The structural and functional similarities of LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection.[1]

References

  1. An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption. Borca, M.V., Kutish, G.F., Afonso, C.L., Irusta, P., Carrillo, C., Brun, A., Sussman, M., Rock, D.L. Virology (1994) [Pubmed]
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