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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

HIV-1/HIV-2 seronegativity in HIV-1 subtype O infected patients.

Nine patients with atypical HIV-1 western blot profiles were diagnosed as having HIV-1 subtype O infection. All the patients were living in France; eight originated from Cameroon and one from France. Lymphocyte DNA amplification by the polymerase chain reaction was only positive when HIV-1 subtype O specific primers were used. Preliminary sequence analysis of amplified products and serological reactivity against a specific subtype O synthetic env peptide confirmed HIV-1 subtype O infection. HIV-1/HIV-2 enzyme-linked immunosorbent assays, especially those based on env peptides or on the sandwich format, can be negative in HIV-1 subtype O infection.[1]

References

  1. HIV-1/HIV-2 seronegativity in HIV-1 subtype O infected patients. Loussert-Ajaka, I., Ly, T.D., Chaix, M.L., Ingrand, D., Saragosti, S., Couroucé, A.M., Brun-Vézinet, F., Simon, F. Lancet (1994) [Pubmed]
 
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