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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Partial attenuation of the cardiovascular responses to tracheal intubation with oral manidipine.

We conducted a placebo-controlled, randomized, and double-blinded study to evaluate the efficacy of manidipine given orally in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation. Thirty normotensive patients (ASA physical status 1) undergoing elective surgery were allocated to one of three groups (n = 10 for each); placebo, 5 mg manidipine, and 10 mg manidipine groups. These tablets were orally administered 3 h before induction of anaesthesia. Anaesthesia was induced with thiopentone 5 iv, and tracheal intubation was facilitated with vecuronium 0.2 Laryngoscopy lasting 30 sec was attempted 2 min after induction of anaesthesia. Patients receiving placebo showed a significant increase in systolic and diastolic blood pressure associated with tracheal intubation. These increases following tracheal intubation were significantly reduced in patients receiving manidipine 10 mg compared with patients receiving placebo or manidipine 5 mg (P < 0.05). Oral administration of manidipine 10 mg before induction of anaesthesia is a simple and effective method for attenuating pressor response to laryngoscopy and tracheal intubation. We stressed that the potential beneficial effect of a reduced haemodynamic reaction to intubation might be obtained at the expense of hypotension later on.[1]


  1. Partial attenuation of the cardiovascular responses to tracheal intubation with oral manidipine. Mikawa, K., Maekawa, N., Nishina, K., Hasegawa, M., Kaetsu, H., Goto, R., Yaku, H., Takao, Y., Obara, H. Acta anaesthesiologica Scandinavica. (1994) [Pubmed]
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