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Chemical Compound Review

Manivasc     2-(4-benzhydrylpiperazin-1- yl)ethyl methyl...

Synonyms: Artedil, Iperten, Manyper, manidipine, Franidipine, ...
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Disease relevance of Franidipine


Psychiatry related information on Franidipine


High impact information on Franidipine

  • Nanomolar concentrations of the five Ca2+ channel blockers amlodipine, felodipine, manidipine, verapamil, or diltiazem significantly decreased both the constitutive and platelet-derived growth factor BB-dependent collagen deposition in the ECM formed by human vascular smooth muscle cells and fibroblasts [7].
  • We conclude that manidipine, at nanomolar concentrations, is efficacious in modulating gene transcriptions that are involved in proinflammatory changes of mesangial cells [8].
  • Additionally, the induction of c-fos, c-jun, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase transcription was inhibited by manidipine [8].
  • Thus, manidipine, at pharmacological concentrations that are one to two orders of magnitude lower than those required for inhibition of agonist- or depolarization (K+)-induced vasoconstriction, causes changes in the activity of the genes that code for inflammatory mediators [8].
  • Treatment of 5/6-nephrectomized rats with TCV-116 or manidipine significantly decreased glomerular expression of alpha-smooth muscle actin and desmin, thereby indicating that these drugs prevented glomerular phenotypic changes in 5/6-nephrectomized rats [9].

Chemical compound and disease context of Franidipine


Biological context of Franidipine


Anatomical context of Franidipine

  • If these results are confirmed, calcium channel antagonists that activate the sympathetic nervous system to a lesser extent, such as manidipine, may become first-choice calcium channel antagonists because of their more favourable adverse event profile [19].
  • Effects of CV-4093, a newly synthesized dihydropiridine type of Ca antagonist, on membrane currents in enzymatically dispersed single smooth muscle cells of the rabbit main pulmonary artery were investigated using the single electrode voltage clamp method [17].
  • CV-4093 apparently has highly selective and long-lasting inhibitory actions on the Ca current in smooth muscle cells of the rabbit main pulmonary artery [17].
  • In small coronary and renal arteries maximally activated with KCl solution, nifedipine and manidipine concentrations dependently inhibited the calcium concentration response curves [20].
  • Nisoldipine was the most potent and CV-4093 was the least potent among these drugs in terms of negative inotropic effect in normally polarized papillary muscles and negative chronotropic effect in right atria of guinea pigs [21].

Associations of Franidipine with other chemical compounds

  • Doxazosin began to decrease renal blood flow at a level of arterial pressure similar to that in manidipine treatment, whereas the maximal decrease in flow (-19 +/- 2%; mean pressure, -33 +/- 2 mm Hg; nerve activity, +225 +/- 44%) was significantly less than that in manidipine treatment [15].
  • Effects of manidipine, a dihydropyridine derivative, on L-type Ca2+ currents were examined in guinea-pig ventricular cells, using the whole-cell patch-clamp method [22].
  • We also observed a statistically significant negative correlation between the change in systolic blood pressure caused by manidipine chloride and the change in hANP levels before and after treatment [13].
  • Determination of manidipine and its pyridine metabolite in human serum by high-performance liquid chromatography with ultraviolet detection and column switching [23].
  • These unexpected vasorelaxant actions of ET-1 in the presence of manidipine were likely caused by the dual effects of antagonism of its own intrinsic vasoconstrictor action (through calcium channel blockade), as well as ET-1-evoked release of the endothelium-derived relaxing factor, nitric oxide [24].

Gene context of Franidipine


Analytical, diagnostic and therapeutic context of Franidipine

  • The effects of manidipine on urinary albumin excretion (UAE) have not been clearly demonstrated in clinical trials in this patient group [16].
  • A stereoselective and highly sensitive method using chiral chromatography and successive column-switching liquid chromatography is described for the determination of manidipine enantiomers in human serum [29].
  • Oral administration of manidipine 10 mg before induction of anaesthesia is a simple and effective method for attenuating pressor response to laryngoscopy and tracheal intubation [30].
  • Manidipine reduced the filtration fraction from 0.260 to 0.243, suggesting a preferential reduction in efferent arteriolar resistance [31].
  • We conducted a placebo-controlled, randomized, and double-blinded study to evaluate the efficacy of manidipine given orally in attenuating the cardiovascular responses to laryngoscopy and tracheal intubation [30].


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  2. Manidipine: a review of its use in the management of hypertension. McKeage, K., Scott, L.J. Drugs (2004) [Pubmed]
  3. Renal protection in hypertensive patients: selection of antihypertensive therapy. Wenzel, R.R. Drugs (2005) [Pubmed]
  4. An evaluation of the renal protective effect of manidipine in the uninephrectomized spontaneously hypertensive rat. Reams, G.P., Villarreal, D., Wu, Z., Wang, X., Luger, A.M., Bauer, J.H. Am. Heart J. (1993) [Pubmed]
  5. Temporary symptom worsening caused by manidipine hydrochloride in two patients with Parkinson's disease. Nakashima, K., Shimoda, M., Kuno, N., Takahashi, K. Mov. Disord. (1994) [Pubmed]
  6. Renal vascular responses in spontaneously hypertensive rats chronically treated with manidipine. Muratani, H., Takishita, S., Kawazoe, N., Tozawa, M., Fukiyama, K. Blood pressure. Supplement. (1992) [Pubmed]
  7. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Roth, M., Eickelberg, O., Kohler, E., Erne, P., Block, L.H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Manidipine regulates the transcription of cytokine genes. Roth, M., Keul, R., Emmons, L.R., Hörl, W.H., Block, L.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Angiotensin II and calcium blockers prevent glomerular phenotypic changes in remnant kidney model. Hamaguchi, A., Kim, S., Wanibuchi, H., Iwao, H. J. Am. Soc. Nephrol. (1996) [Pubmed]
  10. Delapril/manidipine. McCormack, P.L., Keating, G.M. Drugs (2006) [Pubmed]
  11. Effects of an ACE inhibitor and a calcium channel blocker on cardiovascular autonomic nervous system and carotid distensibility in patients with mild to moderate hypertension. Tomiyama, H., Kimura, Y., Sakuma, Y., Shiojima, K., Yamamoto, A., Saito, I., Ishikawa, Y., Yoshida, H., Morita, S., Doba, N. Am. J. Hypertens. (1998) [Pubmed]
  12. Manidipine versus enalapril monotherapy in patients with hypertension and type 2 diabetes mellitus: a multicenter, randomized, double-blind, 24-week study. Otero, M.L., Claros, N.M. Clinical therapeutics. (2005) [Pubmed]
  13. Effect of manidipine chloride on various aspects of endocrine function, including plasma levels of endothelin-1 and human atrial natriuretic peptide, in patients with essential hypertension. Nishikawa, T., Omura, M., Iizuka, T., Chiba, S. Clinical therapeutics. (1996) [Pubmed]
  14. Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension. Zanchetti, A., Omboni, S., La Commare, P., De Cesaris, R., Palatini, P. J. Cardiovasc. Pharmacol. (2001) [Pubmed]
  15. Neural effects on renal blood flow during acute hypotension vary with antihypertensive drugs. Takishita, S., Muratani, H., Kawazoe, N., Kimura, Y., Tozawa, M., Fukiyama, K. Hypertension (1994) [Pubmed]
  16. Manidipine: a review of its use in hypertension. Cheer, S.M., McClellan, K. Drugs (2001) [Pubmed]
  17. Selective and long-lasting inhibitory actions of the dihydropyridine derivative, CV-4093, on calcium currents in smooth muscle cells of the rabbit pulmonary artery. Okabe, K., Terada, K., Kitamura, K., Kuriyama, H. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  18. Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats. Miyoshi, K., Kanda, A., Nozawa, Y., Nakano, M., Miyake, H. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  19. Ankle oedema and sympathetic activation. Fogari, R. Drugs (2005) [Pubmed]
  20. Effects of manidipine and other calcium antagonists on rat renal arcuate arteries. Pfaffendorf, M., Mathy, M.J., van Zwieten, P.A. Am. Heart J. (1993) [Pubmed]
  21. Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. Nakaya, H., Hattori, Y., Nakao, Y., Kanno, M. Eur. J. Pharmacol. (1988) [Pubmed]
  22. Voltage-dependent modulation of L-type Ca2+ current by manidipine in guinea-pig heart cells. Tohse, N., Takeda, Y., Kanno, M. Eur. J. Pharmacol. (1993) [Pubmed]
  23. Determination of manidipine and its pyridine metabolite in human serum by high-performance liquid chromatography with ultraviolet detection and column switching. Miyabayashi, T., Yamashita, K., Aoki, I., Motohashi, M., Yashiki, T., Yatani, K. J. Chromatogr. (1989) [Pubmed]
  24. Studies on the glomerular microcirculatory actions of manidipine and its modulation of the systemic and renal effects of endothelin. Takahashi, K., Katoh, T., Fukunaga, M., Badr, K.F. Am. Heart J. (1993) [Pubmed]
  25. Calcium [corrected] channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells. Toba, H., Shimizu, T., Miki, S., Inoue, R., Yoshimura, A., Tsukamoto, R., Sawai, N., Kobara, M., Nakata, T. Hypertens. Res. (2006) [Pubmed]
  26. Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects. Uno, T., Ohkubo, T., Motomura, S., Sugawara, K. British journal of clinical pharmacology. (2006) [Pubmed]
  27. Effect of manidipine on gene expression and protein level of oxidative stress-related proteins: p22phox and HO-1: relevance for antihypertensive and anti-remodeling effects. Calò, L.A., Zaghetto, F., Pagnin, E., Davis, P.A., Semplicini, A., Pessina, A.C. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  28. Regulation of the gene expression of type-1 angiotensin II receptor in spontaneously hypertensive rats. Kitami, Y., Okura, T., Wakamiya, R., Marumoto, K., Iwata, T., Hiwada, K. Blood pressure. Supplement. (1992) [Pubmed]
  29. Determination of manidipine enantiomers in human serum using chiral chromatography and column-switching liquid chromatography. Yamaguchi, M., Yamashita, K., Aoki, I., Tabata, T., Hirai, S., Yashiki, T. J. Chromatogr. (1992) [Pubmed]
  30. Partial attenuation of the cardiovascular responses to tracheal intubation with oral manidipine. Mikawa, K., Maekawa, N., Nishina, K., Hasegawa, M., Kaetsu, H., Goto, R., Yaku, H., Takao, Y., Obara, H. Acta anaesthesiologica Scandinavica. (1994) [Pubmed]
  31. Renal effects of manidipine hydrochloride. A new calcium antagonist in hypertensive patients. Takabatake, T., Ohta, H., Sasaki, T., Satoh, S., Ohta, K., Ise, T., Kobayashi, K. Eur. J. Clin. Pharmacol. (1993) [Pubmed]
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