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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fluorophotometry in myopic phakic eyes with anterior chamber intraocular lenses to correct severe myopia.

Implanting an anterior chamber intraocular lens in a phakic eye is an effective surgical procedure for the correction of severe myopia. However, the potential risks on the anterior segment structures are scarcely known. We conducted a prospective study to evaluate the permeability of the blood-aqueous barrier and the lens transmittance changes after Worst-Fechner lenses were implanted to correct myopia. Preoperative and serial postoperative fluorophotometry was done in 15 eyes that had a Worst-Fechner lens implanted to correct myopia. Lens transmittance was evaluated by lens autofluorescence, and permeability of the blood-aqueous barrier was estimated by anterior vitreous fluorophotometry, which was carried out before and after intravenous injection of fluorescein. Preoperative lens transmittance was 0.971 +/- 0.002 (mean +/- standard error), and, after the operation, lens transmittance decreased to 0.970 +/- 0.002 at one month, 0.966 +/- 0.001 at three months, 0.964 +/- 0.002 at six months, and 0.962 +/- 0.003 at 14 months. At three, six, and 14 months after the operation, lens transmittance values were significantly lower than preoperative values (P = .038 at three months, P < .001 at six months, and P = .005 at 14 months). Fluorescein concentration in the anterior vitreous was 18.522 +/- 1.797 ng/ml (mean +/- standard error) preoperatively and was 21.328 +/- 1.667 ng/ml at one month, 27.518 +/- 1.412 ng/ml at three months, 27.150 +/- 1.474 ng/ml at six months, and 27.012 +/- 1.980 ng/ml at 14 months postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)[1]


  1. Fluorophotometry in myopic phakic eyes with anterior chamber intraocular lenses to correct severe myopia. Pérez-Santonja, J.J., Hernández, J.L., Benítez del Castillo, J.M., Rodríguez-Bermejo, C., Zato, M.A. Am. J. Ophthalmol. (1994) [Pubmed]
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