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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene.

We describe the isolation, growth-suppressing activity, and chromosomal localization of the human homologue of the murine growth-arrest-specific gene gas1. Overexpression of h- gas1 is able to block cell proliferation in the A549 lung carcinoma and the T24 bladder carcinoma cell lines. No effect was observed when h- gas1 was introduced into the osteosarcoma cell line SAOS-2 and into the adenovirus-type-5 transformed cell line 293. This finding is related to our previous evidence that simian virus 40-transformed NIH 3T3 cells are also refractory to murine gas1 overexpression, suggesting that the retinoblastoma and/or p53 gene products have an active role in mediating the growth- suppressing effect of gas1. We also show that h- gas1 is on chromosome 9q21.3-22.1, in a region considered to be a fragile site. Altogether, the results raise the possibility that h- gas1 may be a target for genetic alterations leading to its inactivation in tumor cells.[1]

References

  1. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene. Del Sal, G., Collavin, L., Ruaro, M.E., Edomi, P., Saccone, S., Valle, G.D., Schneider, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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