The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Line, Transformed

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cell Line, Transformed


High impact information on Cell Line, Transformed

  • The stably transformed cell line, AtT-20ins4b/1, stores immunoreactive insulin, proteolytically processes proinsulin to smaller fragments, and on stimulation with secretagogues releases insulin-like material, not proinsulin, into the medium [6].
  • Among them, STAT3 is often constitutively phosphorylated and activated in human cancers and in transformed cell lines and is implicated in tumorigenesis [7].
  • Transforming growth factor alpha (TGF-alpha) is a 50-amino acid peptide, previously demonstrated only in transformed cell lines and human tumors, which is structurally homologous to epidermal growth factor (EGF) [8].
  • The level of cytoplasmic retinoic acid-binding protein (CRABP) was determined in both parent and transformed cell lines [9].
  • Some changes were observed in the transformed cell lines including an increase in high-molecular-weight glycopeptides and a decrease in the amount of fibronectin (large external transformation-sensitive) protein [10].

Chemical compound and disease context of Cell Line, Transformed


Biological context of Cell Line, Transformed


Anatomical context of Cell Line, Transformed


Associations of Cell Line, Transformed with chemical compounds


Gene context of Cell Line, Transformed


Analytical, diagnostic and therapeutic context of Cell Line, Transformed


  1. Differential effect of imidazole antibiotics on untransformed and virus-transformed rat cell lines. Kuwano, M., Akiyama, S., Kaneko, M., Ikezaki, K., Takaki, R., Kimura, G. Cancer Res. (1982) [Pubmed]
  2. Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines. Elder, D.J., Hague, A., Hicks, D.J., Paraskeva, C. Cancer Res. (1996) [Pubmed]
  3. Expression of p21 ras oncoproteins in human cancers. Tanaka, T., Slamon, D.J., Battifora, H., Cline, M.J. Cancer Res. (1986) [Pubmed]
  4. Effect of adeno-associated virus on transformation of NIH 3T3 cells by ras gene and on tumorigenicity of an NIH 3T3 transformed cell line. Katz, E., Carter, B.J. Cancer Res. (1986) [Pubmed]
  5. Novel recombinations of the IG kappa-locus that result in allelic exclusion. Feddersen, R.M., Martin, D.J., Van Ness, B.G. J. Immunol. (1990) [Pubmed]
  6. Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Moore, H.P., Walker, M.D., Lee, F., Kelly, R.B. Cell (1983) [Pubmed]
  7. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. Yoshida, T., Hanada, T., Tokuhisa, T., Kosai, K., Sata, M., Kohara, M., Yoshimura, A. J. Exp. Med. (2002) [Pubmed]
  8. Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes. Gottlieb, A.B., Chang, C.K., Posnett, D.N., Fanelli, B., Tam, J.P. J. Exp. Med. (1988) [Pubmed]
  9. Inhibition by retinoic acid of murine retrovirus-induced cellular transformation and tumor formation. Giese, N.A., Neary, K.E., Levine, N., Lindell, T.J., Duffy, J.J. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Surface properties of normal, transformed, and temperature-sensitive rat liver epithelial cells. Goldstein, N.I., Fisher, P.B. J. Natl. Cancer Inst. (1981) [Pubmed]
  11. Alteration in expression of smooth muscle alpha-actin associated with transformation of rat 3Y1 cells. Okamoto-Inoue, M., Taniguchi, S., Sadano, H., Kawano, T., Kimura, G., Gabbiani, G., Baba, T. J. Cell. Sci. (1990) [Pubmed]
  12. The relationship between O6-alkylguanine alkyltransferase activity and sensitivity to alkylation-induced sister chromatid exchanges in human lymphoblastoid cell lines. Schwartz, J.L., Turkula, T., Sagher, D., Strauss, B. Carcinogenesis (1989) [Pubmed]
  13. Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein. Pangalos, M.N., Shioi, J., Efthimiopoulos, S., Wu, A., Robakis, N.K. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. (1996) [Pubmed]
  14. Mouse c-mos oncogene activation is prevented by upstream sequences. Wood, T.G., McGeady, M.L., Baroudy, B.M., Blair, D.G., Vande Woude, G.F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  15. Chromosome-mediated gene transfer results in two classes of unstable transformants. Klobutcher, L.A., Miller, C.L., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  16. Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation. Rideout, W.M., Eversole-Cire, P., Spruck, C.H., Hustad, C.M., Coetzee, G.A., Gonzales, F.A., Jones, P.A. Mol. Cell. Biol. (1994) [Pubmed]
  17. Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer. Zhang, X., Jin, T.G., Yang, H., DeWolf, W.C., Khosravi-Far, R., Olumi, A.F. Cancer Res. (2004) [Pubmed]
  18. Enhanced expression and state of the c-myc oncogene in chemically and X-ray-transformed C3H/10T1/2 Cl 8 mouse embryo fibroblasts. Billings, P.C., Shuin, T., Lillehaug, J., Miura, T., Roy-Burman, P., Landolph, J.R. Cancer Res. (1987) [Pubmed]
  19. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Morrison, S.L., Johnson, M.J., Herzenberg, L.A., Oi, V.T. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  20. Role of stromal cells and macrophages in fibronectin biosynthesis and matrix assembly in human long-term marrow cultures. Lerat, H., Lissitzky, J.C., Singer, J.W., Keating, A., Herve, P., Charbord, P. Blood (1993) [Pubmed]
  21. Nuclear protein patterns in normal T-lymphocytes and lymphoblastoid cells. Estañol, J.M., Agell, N., Bachs, O. Cancer Res. (1997) [Pubmed]
  22. Differentiated features of a transformed epithelial cell line (TRKE-1) derived from dimethylnitrosamine-treated rat kidney. Hard, G.C., Mackay, R.L., Martin, J.T., Inoue, K. Cancer Res. (1983) [Pubmed]
  23. Involvement of a putative protein-tyrosine phosphatase and I kappa B-alpha serine phosphorylation in nuclear factor kappa B activation by tumor necrosis factor. Menon, S.D., Guy, G.R., Tan, Y.H. J. Biol. Chem. (1995) [Pubmed]
  24. Transfer of human globin genes to erythroleukemic mouse cells. Spandidos, D.A., Paul, J. EMBO J. (1982) [Pubmed]
  25. Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo. Beyaert, R., Vanhaesebroeck, B., Suffys, P., Van Roy, F., Fiers, W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  26. Quantitative assay for morphogenesis indicates the role of extracellular matrix components and G proteins. Klebe, R.J., Overfelt, T.M., Magnuson, V.L., Steffensen, B., Chen, D.L., Zardeneta, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. Kettelhut, I.C., Fiers, W., Goldberg, A.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells. Ozato, K., Evans, G.A., Shykind, B., Margulies, D.H., Seidman, J.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  29. Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein. Leevers, S.J., Marshall, C.J. EMBO J. (1992) [Pubmed]
  30. Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7. Davies, R.L., Grosse, V.A., Kucherlapati, R., Bothwell, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  31. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. Shi, C.S., Tuscano, J., Kehrl, J.H. Blood (2000) [Pubmed]
  32. Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P., Bulfone-Paus, S. Mol. Cell. Biol. (2005) [Pubmed]
  33. Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4. Tam, S.W., Shay, J.W., Pagano, M. Cancer Res. (1994) [Pubmed]
  34. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. Ambrosini, G., Adida, C., Sirugo, G., Altieri, D.C. J. Biol. Chem. (1998) [Pubmed]
  35. Involvement of somatically acquired ecotropic viruses in the immunogenicity of nude-transplanted NIH/3T3 transformed cell lines. Sensi, M., Bergomi, M., Panceri, P., Castelli, C., Lupetti, R., Traversari, C., Carbone, G., Parmiani, G. J. Immunol. (1992) [Pubmed]
  36. Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1). Impact on oligomerization, stability, and kinetic properties. Berenstein, D., Christensen, J.F., Kristensen, T., Hofbauer, R., Munch-Petersen, B. J. Biol. Chem. (2000) [Pubmed]
  37. Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells. Himelstein, B.P., Canete-Soler, R., Bernhard, E.J., Muschel, R.J. J. Cell. Sci. (1994) [Pubmed]
  38. Expression of keratin genes in mouse epidermis and normal and malignantly transformed epidermal cells in culture. Roop, D.R., Hawley-Nelson, P., Cheng, C.K., Yuspa, S.H. J. Invest. Dermatol. (1983) [Pubmed]
WikiGenes - Universities