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MeSH Review

Cell Line, Transformed

 
 
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Disease relevance of Cell Line, Transformed

 

High impact information on Cell Line, Transformed

  • The stably transformed cell line, AtT-20ins4b/1, stores immunoreactive insulin, proteolytically processes proinsulin to smaller fragments, and on stimulation with secretagogues releases insulin-like material, not proinsulin, into the medium [6].
  • Among them, STAT3 is often constitutively phosphorylated and activated in human cancers and in transformed cell lines and is implicated in tumorigenesis [7].
  • Transforming growth factor alpha (TGF-alpha) is a 50-amino acid peptide, previously demonstrated only in transformed cell lines and human tumors, which is structurally homologous to epidermal growth factor (EGF) [8].
  • The level of cytoplasmic retinoic acid-binding protein (CRABP) was determined in both parent and transformed cell lines [9].
  • Some changes were observed in the transformed cell lines including an increase in high-molecular-weight glycopeptides and a decrease in the amount of fibronectin (large external transformation-sensitive) protein [10].
 

Chemical compound and disease context of Cell Line, Transformed

 

Biological context of Cell Line, Transformed

 

Anatomical context of Cell Line, Transformed

 

Associations of Cell Line, Transformed with chemical compounds

 

Gene context of Cell Line, Transformed

 

Analytical, diagnostic and therapeutic context of Cell Line, Transformed

References

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