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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36.

We have previously shown that human chromosome 2 can complement both the radiation sensitivity and the defect in double strand break rejoining characteristic of ionizing radiation (IR) group 5 mutants. A number of human-hamster hybrids containing segments of human chromosome 2 were obtained by microcell transfer into two group 5 mutants. In most, but not all, of these hybrids, the repair defect was complemented by the human chromosomal DNA. Two complementing microcell hybrids were irradiated and fused to XR-V15B, an IR group 5 mutant, to generate further hybrids bearing smaller regions of chromosome 2. All hybrids were examined for complementation of the repair defect. The region of chromosome 2 present was determined using PCR with primers specific for various human genes located on chromosome 2. A complementing hybrid bearing only a small region of chromosome 2 was finally generated. From this analysis we deduced that the XRCC5 gene was tightly linked to the marker, TNP1, which is located in the region 2q35.[1]

References

  1. Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36. Hafezparast, M., Kaur, G.P., Zdzienicka, M., Athwal, R.S., Lehmann, A.R., Jeggo, P.A. Somat. Cell Mol. Genet. (1993) [Pubmed]
 
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