Gene Review:
XRCC5 - X-ray repair complementing defective...
Homo sapiens
Synonyms:
86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, ...
- Heat-induced aggregation of XRCC5 (Ku80) in nontolerant and thermotolerant cells. Beck, B.D., Dynlacht, J.R. Radiat. Res. (2001)
- Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. Arencibia, J.M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N.R., López-Barahona, M. Int. J. Oncol. (2005)
- Linkage and association analysis of radiation damage repair genes XRCC3 and XRCC5 with nevus density in adolescent twins. Zhu, G., Duffy, D.L., Turner, D.R., Ewen, K.R., Montgomery, G.W., Martin, N.G. Twin research : the official journal of the International Society for Twin Studies. (2003)
- Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. Lim, J.W., Kim, H., Kim, K.H. J. Biol. Chem. (2002)
- Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. Mayeur, G.L., Kung, W.J., Martinez, A., Izumiya, C., Chen, D.J., Kung, H.J. J. Biol. Chem. (2005)
- Personality characteristics of incest survivors on the Draw-A-Person Questionnaire. Waldman, T.L., Silber, D.E., Holmstrom, R.W., Karp, S.A. Journal of personality assessment. (1994)
- The relation of reflection-impulsivity to field dependence-independence and internal-external control in children. Massari, D.J. The Journal of genetic psychology ; child behavior, animal behavior, and comparative psychology. (1975)
- Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Walker, J.R., Corpina, R.A., Goldberg, J. Nature (2001)
- Yeast DNA ligase IV mediates non-homologous DNA end joining. Wilson, T.E., Grawunder, U., Lieber, M.R. Nature (1997)
- Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Taccioli, G.E., Gottlieb, T.M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A.R., Alt, F.W., Jackson, S.P., Jeggo, P.A. Science (1994)
- Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Spagnolo, L., Rivera-Calzada, A., Pearl, L.H., Llorca, O. Mol. Cell (2006)
- KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity. Myung, K., He, D.M., Lee, S.E., Hendrickson, E.A. EMBO J. (1997)
- An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents. Belenkov, A.I., Paiement, J.P., Panasci, L.C., Monia, B.P., Chow, T.Y. Cancer Res. (2002)
- Evaluation of the whole blood lymphocyte transformation assay for scrub typhus exposure: adaptability to field sample collection. Lim, T.S., LaBarre, D.D., Lewis, G.E. Jpn. J. Med. Sci. Biol. (1988)
- Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. Jeggo, P.A., Hafezparast, M., Thompson, A.F., Broughton, B.C., Kaur, G.P., Zdzienicka, M.Z., Athwal, R.S. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. De Silva, I.U., McHugh, P.J., Clingen, P.H., Hartley, J.A. Mol. Cell. Biol. (2000)
- Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. Chen, D.J., Park, M.S., Campbell, E., Oshimura, M., Liu, P., Zhao, Y., White, B.F., Siciliano, M.J. Genomics (1992)
- Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping. Chen, D.J., Marrone, B.L., Nguyen, T., Stackhouse, M., Zhao, Y., Siciliano, M.J. Genomics (1994)
- A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. Blunt, T., Taccioli, G.E., Priestley, A., Hafezparast, M., McMillan, T., Liu, J., Cole, C.C., White, J., Alt, F.W., Jackson, S.P. Genomics (1995)
- Increased expression of human DNA repair genes, XRCC1, XRCC3 and RAD51, in radioresistant human KB carcinoma cell line N10. Yanagisawa, T., Urade, M., Yamamoto, Y., Furuyama, J. Oral Oncol. (1998)
- Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer. Beskow, C., Kanter, L., Holgersson, A., Nilsson, B., Frankendal, B., Avall-Lundqvist, E., Lewensohn, R. Br. J. Cancer (2006)
- The Lethality of Ku86 (XRCC5) Loss-of-Function Mutations in Human Cells is Independent of p53 (TP53). Ghosh, G., Li, G., Myung, K., Hendrickson, E.A. Radiat. Res. (2007)
- Adenovirus-mediated expression of a dominant negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions. He, F., Li, L., Kim, D., Wen, B., Deng, X., Gutin, P.H., Ling, C.C., Li, G.C. Cancer Res. (2007)
- Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Munshi, A., Tanaka, T., Hobbs, M.L., Tucker, S.L., Richon, V.M., Meyn, R.E. Mol. Cancer Ther. (2006)
- Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. Rivera-Calzada, A., Spagnolo, L., Pearl, L.H., Llorca, O. EMBO Rep. (2007)
- Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. Li, B., Comai, L. J. Biol. Chem. (2001)
- Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. Suzuki, K., Kodama, S., Watanabe, M. J. Biol. Chem. (1999)
- Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism. Brown, K.D., Lataxes, T.A., Shangary, S., Mannino, J.L., Giardina, J.F., Chen, J., Baskaran, R. J. Biol. Chem. (2000)
- Coordinated regulation of the promoter and enhancer regions of human CD23 gene by signal through IL-4R and CD40, and the role of Ku70/80 in the enhancer activity. Imai, M., Mizutani, S., Morio, T. J. Med. Dent. Sci. (2003)
- The expression and the nuclear activity of the caretaker gene ku86 are modulated by somatostatin. Pucci, S., Bonanno, E., Pichiorri, F., Mazzarelli, P., Spagnoli, L.G. European journal of histochemistry : EJH. (2004)
- DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks. Drouet, J., Delteil, C., Lefrançois, J., Concannon, P., Salles, B., Calsou, P. J. Biol. Chem. (2005)
- Microsatellite polymorphisms in DNA repair genes XRCC1, XRCC3 and XRCC5 in patients with gynecological tumors: association with late clinical radiosensitivity and cancer incidence. De Ruyck, K., Wilding, C.S., Van Eijkeren, M., Morthier, R., Tawn, E.J., Thierens, H. Radiat. Res. (2005)
- DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues. Moll, U., Lau, R., Sypes, M.A., Gupta, M.M., Anderson, C.W. Oncogene (1999)
- Human neutrophils isolated from peripheral blood contain Ku protein but not DNA-dependent protein kinase. Kurosawa, A., Shinohara, K., Watanabe, F., Shimizu-Saito, K., Koiwai, O., Yamamoto, K., Teraoka, H. Int. J. Biochem. Cell Biol. (2003)
- Ku autoantigen (DNA helicase) is required for interleukins-13/-4-induction of 15-lipoxygenase-1 gene expression in human epithelial cells. Kelavkar, U.P., Wang, S., Badr, K.F. Genes Immun. (2000)