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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic mice.

Transgenic mice constitutively expressing IL-7 developed severe dermatitis with erythroderma and alopecia. The skin lesions were characterized by massive infiltration of mononuclear cells. Immunofluorescence staining showed that most of the infiltrating cells were T cells with the majority bearing the gamma delta TCR other than the V gamma 5 moiety. Furthermore, the number of gamma delta T cells had increased in the lymphoid organs of the dermatitis animals. These findings indicate the strong relationship between the expression of IL-7 and the development of gamma delta T cells in vivo and the pathological involvement of proliferated and/or activated gamma delta T cells in skin disease.[1]

References

  1. The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic mice. Uehira, M., Matsuda, H., Hikita, I., Sakata, T., Fujiwara, H., Nishimoto, H. Int. Immunol. (1993) [Pubmed]
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