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MeSH Review

Dermatitis, Exfoliative

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Disease relevance of Dermatitis, Exfoliative


High impact information on Dermatitis, Exfoliative


Chemical compound and disease context of Dermatitis, Exfoliative


Biological context of Dermatitis, Exfoliative


Anatomical context of Dermatitis, Exfoliative


Gene context of Dermatitis, Exfoliative

  • Keratin gene mutations can influence the filament integrity thereby causing several heritable blistering disorders of the skin such as epidermolysis bullosa, bullous icthyosiform erythroderma, etc [17].
  • In 5 patients with idiopathic erythroderma we detected T-cell clones in peripheral blood (in 1 case, associated with the presence of the same clone in the skin) and a 2-fold increase in the proportion of CD3+ CD4+ CD7- CD26- cells [18].
  • RESULTS: Mean endothelial expression in erythroderma was as follows: VCAM-1 51.4%, ICAM-1 70.1%, E-selectin 43.5%, and P-selectin 52.6% [19].
  • INTERPRETATION AND CONCLUSIONS: The presence of CD28+/CD5+/NKa-/CD4+ T cells expressing abnormally low levels of CD3, TCRalphabeta, CD4, CD7 and/or CD2 would support the diagnosis of SS in patients with erythroderma [20].
  • Blood involvement was related to the type of cutaneous T-stage, being present in 90% of patients with erythroderma (T4), 27% of those with cutaneous tumors (T3), 9% of those with generalized (T2), and 0% of those with limited skin plaques (T1) [21].

Analytical, diagnostic and therapeutic context of Dermatitis, Exfoliative


  1. Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital. Kahn, H.D., Faguet, G.B., Agee, J.F., Middleton, H.M. Arch. Intern. Med. (1984) [Pubmed]
  2. Cutaneous adverse reactions associated with calcium channel blockers. Stern, R., Khalsa, J.H. Arch. Intern. Med. (1989) [Pubmed]
  3. Efficacy and safety of aztreonam in the treatment of serious gram-negative bacterial infections. LeFrock, J.L., Smith, B.R., Chandrasekar, P., Rolston, K.V., Molavi, A., Kannangara, W. Arch. Intern. Med. (1987) [Pubmed]
  4. Etretinate-induced skeletal muscle damage. Hodak, E., David, M., Gadoth, N., Sandbank, M. Br. J. Dermatol. (1987) [Pubmed]
  5. An appraisal of acitretin therapy in children with inherited disorders of keratinization. Lacour, M., Mehta-Nikhar, B., Atherton, D.J., Harper, J.I. Br. J. Dermatol. (1996) [Pubmed]
  6. Toxic erythroderma due to ticlopidine. Hsi, D.H., Mock, D.J., Rocco, T.A. N. Engl. J. Med. (1999) [Pubmed]
  7. Dermatologic changes associated with interleukin 2 administration. Gaspari, A.A., Lotze, M.T., Rosenberg, S.A., Stern, J.B., Katz, S.I. JAMA (1987) [Pubmed]
  8. Chlorpropamide-induced granulomas. A probable hypersensitivity reaction in liver and bone marrow. Rigberg, L.A., Robinson, M.J., Espiritu, C.R. JAMA (1976) [Pubmed]
  9. Circulating vascular permeability factor/vascular endothelial growth factor in erythroderma. Creamer, D., Allen, M.H., Groves, R.W., Barker, J.N. Lancet (1996) [Pubmed]
  10. Association of erythrodermic cutaneous T-cell lymphoma, superantigen-positive Staphylococcus aureus, and oligoclonal T-cell receptor V beta gene expansion. Jackow, C.M., Cather, J.C., Hearne, V., Asano, A.T., Musser, J.M., Duvic, M. Blood (1997) [Pubmed]
  11. Scleromyxedema myopathy: case report and review of the literature. Helfrich, D.J., Walker, E.R., Martinez, A.J., Medsger, T.A. Arthritis Rheum. (1988) [Pubmed]
  12. Exfoliative dermatitis during cefoxitin therapy. Kannangara, D.W., Smith, B., Cohen, K. Arch. Intern. Med. (1982) [Pubmed]
  13. Exfoliative dermatitis during lithium treatment. Kuhnley, E.J., Granoff, A.L. The American journal of psychiatry. (1979) [Pubmed]
  14. Zidovudine-related erythroderma and successful desensitization: a case report. Duque, S., de la Puente, J., Rodríguez, F., Fernandez Pellón, L., Maquiera, E., Jerez, J. J. Allergy Clin. Immunol. (1996) [Pubmed]
  15. Generalized eruption with severe liver dysfunction associated with occupational exposure to trichloroethylene. Nakayama, H., Kobayashi, M., Takahashi, M., Ageishi, Y., Takano, T. Contact Derm. (1988) [Pubmed]
  16. Interleukin 4 and interferon-gamma expression of the dermal infiltrate in patients with erythroderma and mycosis fungoides. An immuno-histochemical study. Sigurdsson, V., Toonstra, J., Bihari, I.C., Bruijnzeel-Koomen, C.A., van Vloten, W.A., Thepen, T. J. Cutan. Pathol. (2000) [Pubmed]
  17. Keratins and skin disorders. Rao, K.S., Babu, K.K., Gupta, P.D. Cell Biol. Int. (1996) [Pubmed]
  18. Monoclonal T-cell dyscrasia of undetermined significance associated with recalcitrant erythroderma. Gniadecki, R., Lukowsky, A. Archives of dermatology. (2005) [Pubmed]
  19. Expression of VCAM-1, ICAM-1, E-selectin, and P-selectin on endothelium in situ in patients with erythroderma, mycosis fungoides and atopic dermatitis. Sigurdsson, V., de Vries, I.J., Toonstra, J., Bihari, I.C., Thepen, T., Bruijnzeel-Koomen, C.A., van Vloten, W.A. J. Cutan. Pathol. (2000) [Pubmed]
  20. Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sézary's syndrome. Lima, M., Almeida, J., dos Anjos Teixeira, M., Queiros, M.L., Santos, A.H., Fonseca, S., Balanzategui, A., Justica, B., Orfao, A. Haematologica (2003) [Pubmed]
  21. Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma. Schechter, G.P., Sausville, E.A., Fischmann, A.B., Soehnlen, F., Eddy, J., Matthews, M., Gazdar, A., Guccion, J., Munson, D., Makuch, R. Blood (1987) [Pubmed]
  22. Paraneoplastic erythroderma in a prostate cancer patient. Momm, F., Pflieger, D., Lutterbach, J. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (2002) [Pubmed]
  23. Localization of haptoglobin in normal human skin and some skin diseases. Li, P., Gao, X.H., Chen, H.D., Zhang, Y., Wang, Y., Wang, H., Wang, Y., Xie, Y. International journal of dermatology. (2005) [Pubmed]
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