Gene Review:
Il7 - interleukin 7
Mus musculus
Synonyms:
A630026I06Rik, IL-7, Il-7, Interleukin-7, hlb368
- Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Maeurer, M.J., Trinder, P., Hommel, G., Walter, W., Freitag, K., Atkins, D., Störkel, S. Infect. Immun. (2000)
- Antitumor effect of interleukin 7 in combination with local hyperthermia in mice bearing B16a melanoma cells. Wu, B., Shen, R.N., Wang, W.X., Broxmeyer, H.E., Lu, L. Stem Cells (1993)
- Interleukin-7 enhances cell-mediated immune responses in vivo in an interleukin-2-dependent manner. Leong, K.H., Ramshaw, I.A., Ramsay, A.J. Viral Immunol. (1997)
- The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. Annu. Rev. Immunol. (1996)
- Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C.T., Bryder, D., Yang, L., Borge, O.J., Thoren, L.A., Anderson, K., Sitnicka, E., Sasaki, Y., Sigvardsson, M., Jacobsen, S.E. Cell (2005)
- Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I.L. Cell (1997)
- IL-15 and IL-2: a matter of life and death for T cells in vivo. Li, X.C., Demirci, G., Ferrari-Lacraz, S., Groves, C., Coyle, A., Malek, T.R., Strom, T.B. Nat. Med. (2001)
- Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Corcoran, A.E., Riddell, A., Krooshoop, D., Venkitaraman, A.R. Nature (1998)
- Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. Weitzmann, M.N., Roggia, C., Toraldo, G., Weitzmann, L., Pacifici, R. J. Clin. Invest. (2002)
- Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells. Sharma, S., Miller, P.W., Stolina, M., Zhu, L., Huang, M., Paul, R.W., Dubinett, S.M. Gene Ther. (1997)
- Effect of MTP-PE liposomes and interleukin-7 on induction of antibody and cell-mediated immune responses to a recombinant HIV-envelope protein. Bui, T., Dykers, T., Hu, S.L., Faltynek, C.R., Ho, R.J. J. Acquir. Immune Defic. Syndr. (1994)
- Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Muegge, K., Vila, M.P., Durum, S.K. Science (1993)
- Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. Seet, C.S., Brumbaugh, R.L., Kee, B.L. J. Exp. Med. (2004)
- Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice. Osborne, L.C., Dhanji, S., Snow, J.W., Priatel, J.J., Ma, M.C., Miners, M.J., Teh, H.S., Goldsmith, M.A., Abraham, N. J. Exp. Med. (2007)
- Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Winkler, T.H., Melchers, F., Rolink, A.G. Blood (1995)
- Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Harnaha, J., Machen, J., Wright, M., Lakomy, R., Styche, A., Trucco, M., Makaroun, S., Giannoukakis, N. Diabetes (2006)
- Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. Dias, S., Silva, H., Cumano, A., Vieira, P. J. Exp. Med. (2005)
- Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma. Hock, H., Dorsch, M., Kunzendorf, U., Qin, Z., Diamantstein, T., Blankenstein, T. Proc. Natl. Acad. Sci. U.S.A. (1993)
- A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B-cell colony formation and an inhibitory effect of IL-1 alpha. Suda, T., Okada, S., Suda, J., Miura, Y., Ito, M., Sudo, T., Hayashi, S., Nishikawa, S., Nakauchi, H. Blood (1989)
- Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Khaled, A.R., Li, W.Q., Huang, J., Fry, T.J., Khaled, A.S., Mackall, C.L., Muegge, K., Young, H.A., Durum, S.K. Immunity (2002)
- Interleukin 7 is a T-cell growth factor. Chazen, G.D., Pereira, G.M., LeGros, G., Gillis, S., Shevach, E.M. Proc. Natl. Acad. Sci. U.S.A. (1989)
- IL-7 induces tyrosine phosphorylation of clathrin heavy chain. Jiang, Q., Benbernou, N., Chertov, O., Khaled, A.R., Wooters, J., Durum, S.K. Cell. Signal. (2004)
- Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S., Sugamura, K. Science (1994)
- Identification of an IL-7-associated pre-pro-B cell growth-stimulating factor (PPBSF). I. Production of the non-IL-7 component by bone marrow stromal cells from IL-7 gene-deleted mice. McKenna, S.D., Chen, F., Lai, L., Goldschneider, I. J. Immunol. (1998)
- Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. Li, W.Q., Jiang, Q., Khaled, A.R., Keller, J.R., Durum, S.K. J. Biol. Chem. (2004)
- Interleukin 7 stimulates growth of fetal thymic precursors of cytolytic cells: induction of effector function by interleukin 2 and inhibition by interleukin 4. Widmer, M.B., Morrissey, P.J., Namen, A.E., Voice, R.F., Watson, J.D. Int. Immunol. (1990)
- A regulatory role of c-Fos in the development of precursor B lymphocytes mediated by interleukin-7. Imoto, S., Hu, L., Tomita, Y., Phuchareon, J., Ruther, U., Tokuhisa, T. Cell. Immunol. (1996)
- Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade. Wang, Y., Dai, H., Liu, Z., Cheng, X., Tellides, G., Dai, Z. Am. J. Transplant. (2006)
- Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Sexl, V., Piekorz, R., Moriggl, R., Rohrer, J., Brown, M.P., Bunting, K.D., Rothammer, K., Roussel, M.F., Ihle, J.N. Blood (2000)
- Cloning and expression of a cDNA encoding ovine interleukin 7. Barcham, G.J., Andrews, A.E., Nash, A.D. Gene (1995)
- Interleukin-2 and interleukin-7 augment the cytolytic activity and expand the antitumor killing spectrum of alpha CD3-induced activated killer cells: potential use in the immunotherapy of non-immunogenic tumors. Ting, C.C., Wang, J., Yang, Y. Cancer Immunol. Immunother. (1996)
- IL-7 is critical for homeostatic proliferation and survival of naive T cells. Tan, J.T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K.I., Surh, C.D. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Suppression of B-cell development as a result of selective expansion of donor T cells during the minor H antigen graft-versus-host reaction. Garvy, B.A., Elia, J.M., Hamilton, B.L., Riley, R.L. Blood (1993)
- Ontogeny and regulation of IL-7-expressing thymic epithelial cells. Zamisch, M., Moore-Scott, B., Su, D.M., Lucas, P.J., Manley, N., Richie, E.R. J. Immunol. (2005)