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Gene Review

Il7  -  interleukin 7

Mus musculus

Synonyms: A630026I06Rik, IL-7, Il-7, Interleukin-7, hlb368
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Disease relevance of Il7


High impact information on Il7

  • Among the cytokines sharing the gamma chain, at least IL-7 is essentially involved in early T cell development in the mouse organ culture system [4].
  • In agreement with representing a lymphoid primed progenitor, Lin-Sca-1+c-kit+CD34+Flt3+ cells display upregulated IL-7 receptor gene expression [5].
  • IL-7 and IL-7 receptor functions are believed to result in lymphoid cell proliferation and cell maturation, implying signal transduction pathways directly involved in mitogenesis and elaboration of developmentally specific new gene programs [6].
  • The gamma-chain is also a critical signaling component of IL-4, IL-7 and IL-9 receptors [7].
  • Here we report that this process is regulated by the alpha-chain of the receptor for interleukin-7, a cytokine that stimulates B-cell lymphopoiesis [8].

Chemical compound and disease context of Il7


Biological context of Il7


Anatomical context of Il7


Associations of Il7 with chemical compounds

  • The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7 [20].
  • Stimulation of T cells with phorbol myristate acetate and IL-2, IL-4, or IL-7 prepared T cells to respond to any of the three lymphokines [21].
  • We demonstrate here that IL-7 in combination with phorbol 12-myristate 13-acetate can directly drive the proliferation of purified T cells and that this response is not inhibited by cyclosporine A or by antibodies to IL-2 and IL-4 [21].
  • Removal of the growth factors (IL-7, respectively IL-3) from the cultures results in differentiation to surface immunoglobulin (slg) positive, c-kit-, CD43-, surrogate light chain- B cells, a fraction of which is lipopolysaccharide (LPS) responsive as shown by IgM secretion [15].
  • Anti-phosphotyrosine antibody was used both to immunoprecipitate and Western blot, and showed that IL-7 induced tyrosine phosphorylation of a protein with a molecular weight of approximately 200 kDa [22].

Physical interactions of Il7

  • Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells [23].
  • The antianabolic effects of IL-7 were consistent with an observed downregulation of the osteoblast-specific transcription factor core-binding factor alpha1/Runx2 [9].

Enzymatic interactions of Il7

  • Inasmuch as IL-7 is one of the cytokines most closely associated with early B-lineage development, we utilized BM adherent cells and stromal cell lines from IL-7 gene-deleted (-/-) mice in combination with rIL-7 and anti-IL-7 mAb to investigate its possible regulatory role in our culture system [24].

Regulatory relationships of Il7


Other interactions of Il7


Analytical, diagnostic and therapeutic context of Il7


  1. Interleukin-7 or interleukin-15 enhances survival of Mycobacterium tuberculosis-infected mice. Maeurer, M.J., Trinder, P., Hommel, G., Walter, W., Freitag, K., Atkins, D., Störkel, S. Infect. Immun. (2000) [Pubmed]
  2. Antitumor effect of interleukin 7 in combination with local hyperthermia in mice bearing B16a melanoma cells. Wu, B., Shen, R.N., Wang, W.X., Broxmeyer, H.E., Lu, L. Stem Cells (1993) [Pubmed]
  3. Interleukin-7 enhances cell-mediated immune responses in vivo in an interleukin-2-dependent manner. Leong, K.H., Ramshaw, I.A., Ramsay, A.J. Viral Immunol. (1997) [Pubmed]
  4. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M., Takeshita, T. Annu. Rev. Immunol. (1996) [Pubmed]
  5. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C.T., Bryder, D., Yang, L., Borge, O.J., Thoren, L.A., Anderson, K., Sitnicka, E., Sasaki, Y., Sigvardsson, M., Jacobsen, S.E. Cell (2005) [Pubmed]
  6. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R., Weissman, I.L. Cell (1997) [Pubmed]
  7. IL-15 and IL-2: a matter of life and death for T cells in vivo. Li, X.C., Demirci, G., Ferrari-Lacraz, S., Groves, C., Coyle, A., Malek, T.R., Strom, T.B. Nat. Med. (2001) [Pubmed]
  8. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Corcoran, A.E., Riddell, A., Krooshoop, D., Venkitaraman, A.R. Nature (1998) [Pubmed]
  9. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. Weitzmann, M.N., Roggia, C., Toraldo, G., Weitzmann, L., Pacifici, R. J. Clin. Invest. (2002) [Pubmed]
  10. Multicomponent gene therapy vaccines for lung cancer: effective eradication of established murine tumors in vivo with interleukin-7/herpes simplex thymidine kinase-transduced autologous tumor and ex vivo activated dendritic cells. Sharma, S., Miller, P.W., Stolina, M., Zhu, L., Huang, M., Paul, R.W., Dubinett, S.M. Gene Ther. (1997) [Pubmed]
  11. Effect of MTP-PE liposomes and interleukin-7 on induction of antibody and cell-mediated immune responses to a recombinant HIV-envelope protein. Bui, T., Dykers, T., Hu, S.L., Faltynek, C.R., Ho, R.J. J. Acquir. Immune Defic. Syndr. (1994) [Pubmed]
  12. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. Muegge, K., Vila, M.P., Durum, S.K. Science (1993) [Pubmed]
  13. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. Seet, C.S., Brumbaugh, R.L., Kee, B.L. J. Exp. Med. (2004) [Pubmed]
  14. Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice. Osborne, L.C., Dhanji, S., Snow, J.W., Priatel, J.J., Ma, M.C., Miners, M.J., Teh, H.S., Goldsmith, M.A., Abraham, N. J. Exp. Med. (2007) [Pubmed]
  15. Interleukin-3 and interleukin-7 are alternative growth factors for the same B-cell precursors in the mouse. Winkler, T.H., Melchers, F., Rolink, A.G. Blood (1995) [Pubmed]
  16. Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Harnaha, J., Machen, J., Wright, M., Lakomy, R., Styche, A., Trucco, M., Makaroun, S., Giannoukakis, N. Diabetes (2006) [Pubmed]
  17. Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. Dias, S., Silva, H., Cumano, A., Vieira, P. J. Exp. Med. (2005) [Pubmed]
  18. Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin 2, interleukin 4, interleukin 7, tumor necrosis factor, or interferon gamma. Hock, H., Dorsch, M., Kunzendorf, U., Qin, Z., Diamantstein, T., Blankenstein, T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B-cell colony formation and an inhibitory effect of IL-1 alpha. Suda, T., Okada, S., Suda, J., Miura, Y., Ito, M., Sudo, T., Hayashi, S., Nishikawa, S., Nakauchi, H. Blood (1989) [Pubmed]
  20. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Khaled, A.R., Li, W.Q., Huang, J., Fry, T.J., Khaled, A.S., Mackall, C.L., Muegge, K., Young, H.A., Durum, S.K. Immunity (2002) [Pubmed]
  21. Interleukin 7 is a T-cell growth factor. Chazen, G.D., Pereira, G.M., LeGros, G., Gillis, S., Shevach, E.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. IL-7 induces tyrosine phosphorylation of clathrin heavy chain. Jiang, Q., Benbernou, N., Chertov, O., Khaled, A.R., Wooters, J., Durum, S.K. Cell. Signal. (2004) [Pubmed]
  23. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S., Sugamura, K. Science (1994) [Pubmed]
  24. Identification of an IL-7-associated pre-pro-B cell growth-stimulating factor (PPBSF). I. Production of the non-IL-7 component by bone marrow stromal cells from IL-7 gene-deleted mice. McKenna, S.D., Chen, F., Lai, L., Goldschneider, I. J. Immunol. (1998) [Pubmed]
  25. Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. Li, W.Q., Jiang, Q., Khaled, A.R., Keller, J.R., Durum, S.K. J. Biol. Chem. (2004) [Pubmed]
  26. Interleukin 7 stimulates growth of fetal thymic precursors of cytolytic cells: induction of effector function by interleukin 2 and inhibition by interleukin 4. Widmer, M.B., Morrissey, P.J., Namen, A.E., Voice, R.F., Watson, J.D. Int. Immunol. (1990) [Pubmed]
  27. A regulatory role of c-Fos in the development of precursor B lymphocytes mediated by interleukin-7. Imoto, S., Hu, L., Tomita, Y., Phuchareon, J., Ruther, U., Tokuhisa, T. Cell. Immunol. (1996) [Pubmed]
  28. Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade. Wang, Y., Dai, H., Liu, Z., Cheng, X., Tellides, G., Dai, Z. Am. J. Transplant. (2006) [Pubmed]
  29. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Sexl, V., Piekorz, R., Moriggl, R., Rohrer, J., Brown, M.P., Bunting, K.D., Rothammer, K., Roussel, M.F., Ihle, J.N. Blood (2000) [Pubmed]
  30. Cloning and expression of a cDNA encoding ovine interleukin 7. Barcham, G.J., Andrews, A.E., Nash, A.D. Gene (1995) [Pubmed]
  31. Interleukin-2 and interleukin-7 augment the cytolytic activity and expand the antitumor killing spectrum of alpha CD3-induced activated killer cells: potential use in the immunotherapy of non-immunogenic tumors. Ting, C.C., Wang, J., Yang, Y. Cancer Immunol. Immunother. (1996) [Pubmed]
  32. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Tan, J.T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K.I., Surh, C.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. Suppression of B-cell development as a result of selective expansion of donor T cells during the minor H antigen graft-versus-host reaction. Garvy, B.A., Elia, J.M., Hamilton, B.L., Riley, R.L. Blood (1993) [Pubmed]
  34. Ontogeny and regulation of IL-7-expressing thymic epithelial cells. Zamisch, M., Moore-Scott, B., Su, D.M., Lucas, P.J., Manley, N., Richie, E.R. J. Immunol. (2005) [Pubmed]
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