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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Subclinical affection of liver and kidney function and solvent exposure.

The role of solvents as hepato- and nephrotoxic agents under present-day exposure levels is still unclear. The purpose of this study involving 99 metal degreasers was to examine dose-response relationships between long-term exposure of mainly trichloroethylene and a battery of liver function tests and one nephrotubular enzyme test. Serum gamma-glutamyltransferase and urinary N-acetyl-beta-glucosaminidase were elevated by increasing solvent exposure at bivariate level. The significance of this relationship, however, was not able to withstand a multiple regression analysis, with age and alcohol abuse as confounding variables. The conclusion is that of a nonsignificant association between solvent exposure and tests screening for early liver and kidney dysfunction.[1]


  1. Subclinical affection of liver and kidney function and solvent exposure. Rasmussen, K., Brogren, C.H., Sabroe, S. International archives of occupational and environmental health. (1993) [Pubmed]
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