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MeSH Review

Enzyme Tests

 
 
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Disease relevance of Enzyme Tests

 

Psychiatry related information on Enzyme Tests

 

High impact information on Enzyme Tests

  • In this study, we investigated the role of caspases, the key regulators of apoptosis, and employed two novel caspase assays, an immunological and a luminometric enzyme test, to detect hepatic caspase activation in sera from HCV patients with different grades of steatosis [5].
  • Enzyme tests were carried out on the nuclear transplant embryos, using electrophoretic variants of glucose phosphate isomerase (GPI) in order to distinguish between EC nuclei (GPI-A) and recipient eggs (GPI-B) [6].
  • Ursodeoxycholic acid has resulted in improvement of liver enzyme tests [7].
  • The linkage of substrate deprotonation to flavin movement constitutes a novel mode of molecular recognition in which the enzyme tests the suitability of aromatic substrates before committing to the catalytic cycle [8].
  • The patients who received isoflurane and those who received midazolam showed no significant differences in any of the enzyme tests [9].
 

Anatomical context of Enzyme Tests

 

Associations of Enzyme Tests with chemical compounds

 

Gene context of Enzyme Tests

  • Reverse transcription-polymerase chain reaction-based restriction enzyme tests for CYP2C21 and 2C41 mRNAs as well as polymerase chain reaction-based tests for genomic DNA were developed [16].
  • Enzyme tests with AKR-specific substrates suggest that GCY encodes a carbonyl reductase [17].
  • Eight nondrinking controls showed only slight increases in serum GGT following the same alcohol challenge; results for the other enzyme tests were unchanged [18].
  • Further measurement of the IC50(HDAC) values of VPA derivatives in a human HDAC enzyme test system revealed an activity range from 10 to 10 000 microM; in some derivatives, HDAC inhibition ability was 40 times that of VPA [19].
  • An allele-specific polymerase chain reaction-based restriction enzyme test was developed for genotyping individual dogs from genomic DNA samples [20].
 

Analytical, diagnostic and therapeutic context of Enzyme Tests

  • RESULTS: All sera were negative in microcolumn indirect antiglobulin test and enzyme test, positive in 58% of samples in the enzyme tube test [21].
  • The performance of a test enzyme preparation in the technique for which it is recommended for use should be at least equal to that of the reference papain preparation, by the reference two-stage technique in terms of sensitivity, using a titration series of the reference anti-D, and freedom from false-positive reactions, using six fresh inert sera [22].
  • The purpose of this study involving 99 metal degreasers was to examine dose-response relationships between long-term exposure of mainly trichloroethylene and a battery of liver function tests and one nephrotubular enzyme test [23].

References

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  4. A study of compliance with FDA recommendations for pemoline (Cylert). Willy, M.E., Manda, B., Shatin, D., Drinkard, C.R., Graham, D.J. Journal of the American Academy of Child and Adolescent Psychiatry. (2002) [Pubmed]
  5. The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Seidel, N., Volkmann, X., Länger, F., Flemming, P., Manns, M.P., Schulze-Osthoff, K., Bantel, H. Hepatology (2005) [Pubmed]
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  8. Substrate recognition by "password" in p-hydroxybenzoate hydroxylase. Palfey, B.A., Moran, G.R., Entsch, B., Ballou, D.P., Massey, V. Biochemistry (1999) [Pubmed]
  9. Aspartate aminotransferase, alanine aminotransferase, and glutathione transferase in plasma during and after sedation by low-dose isoflurane or midazolam. Howie, A.F., Spencer, E., Beckett, G.J. Clin. Chem. (1992) [Pubmed]
  10. Successful treatment of systemic amyloidosis with hepatic involvement and factor X deficiency by high dose melphalan chemotherapy and autologous stem cell reinfusion. Breems, D.A., Sonneveld, P., de Man, R.A., Leebeek, F.W. Eur. J. Haematol. (2004) [Pubmed]
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  13. Emetine identified in urine by HPLC, with fluorescence and ultraviolet/diode array detection, in a patient with cardiomyopathy. Lachman, M.F., Romeo, R., McComb, R.B. Clin. Chem. (1989) [Pubmed]
  14. Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. DeFrees, S.A., Sawick, D.P., Cunningham, B., Heinstein, P.F., Morré, D.J., Cassady, J.M. Biochem. Pharmacol. (1988) [Pubmed]
  15. Numerical classification and identification of Streptomyces species--a review. Goodfellow, M., Ferguson, E.V., Sanglier, J.J. Gene (1992) [Pubmed]
  16. Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression. Blaisdell, J., Goldstein, J.A., Bai, S.A. Drug Metab. Dispos. (1998) [Pubmed]
  17. Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases. Magdolen, V., Oechsner, U., Trommler, P., Bandlow, W. Gene (1990) [Pubmed]
  18. Changes in serum enzymes in moderate drinkers after an alcohol challenge. Nemesánszky, E., Lott, J.A., Arato, M. Clin. Chem. (1988) [Pubmed]
  19. Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives. Eikel, D., Lampen, A., Nau, H. Chem. Res. Toxicol. (2006) [Pubmed]
  20. Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles. Lankford, S.M., Bai, S.A., Goldstein, J.A. Drug Metab. Dispos. (2000) [Pubmed]
  21. Evaluation of the microcolumn technology for pretransfusion testing in multiple myeloma patients. Fabijańska-Mitek, J., Zupańska, B., Pogłód, R., Gorajek, M., Lopieńska, H., Kraj, M. Vox Sang. (1998) [Pubmed]
  22. Review of the problems involved in using enzymes in blood group serology--provision of freeze-dried ICSH/ISBT protease enzyme and anti-D reference standards. International Council for Standardization in Haematology. International Society of Blood Transfusion. Scott, M.L., Voak, D., Phillips, P.K., Hoppe, P.A., Kochman, S.A. Vox Sang. (1994) [Pubmed]
  23. Subclinical affection of liver and kidney function and solvent exposure. Rasmussen, K., Brogren, C.H., Sabroe, S. International archives of occupational and environmental health. (1993) [Pubmed]
 
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