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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A.

US31 is a UV-sensitive mutant cell line (rodent complementation group 8) derived from a mouse T cell line L5178Y. We analyzed removal kinetics for UV-induced cyclobutane pyrimidine dimers and (6-4) photoproducts in US31 cells using monoclonal antibodies against these photoproducts. While nearly all (6-4) photoproducts were repaired within 6 h after UV-irradiation, more than 70% of cyclobutane pyrimidine dimers remained unrepaired even 24 h after UV-irradiation. These kinetics resembled those of Cockayne syndrome (CS) cells. Since US31 cells had a low efficiency of cell fusion and transfection, which hampered both complementation tests and gene cloning, we constructed fibroblastic complementation group 8 cell line 6L1030 by fusion of US31 cells with X-irradiated normal mouse fibroblastic LTA cells. Complementation tests by cell fusion and transfection using 6L1030 cells revealed that rodent complementation group 8 corresponded to CS complementation group A.[1]


  1. Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A. Itoh, T., Shiomi, T., Shiomi, N., Harada, Y., Wakasugi, M., Matsunaga, T., Nikaido, O., Friedberg, E.C., Yamaizumi, M. Mutat. Res. (1996) [Pubmed]
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