The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

ERCC8  -  excision repair cross-complementation group 8

Homo sapiens

Synonyms: CKN1, CSA, Cockayne syndrome WD repeat protein CSA, DNA excision repair protein ERCC-8, UVSS2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ERCC8

 

Psychiatry related information on ERCC8

  • METHODS: Polysomnograms with digitized video surveillance of 20 consecutive patients with heart failure and CSA-CSR were analyzed for total apnea-hypopnea index, mean event duration, and mean oxygen desaturation according to sleep stage and position [3].
  • PURPOSE: The purpose of this study was to evaluate the Computer Science and Applications, Inc. (CSA) activity monitor to quantify physical activity in free living subjects using an activity diary as the criterion measure [5].
 

High impact information on ERCC8

  • These results suggest that the distinct UV response of the DDB2 and CSA complexes is involved in diverse mechanisms of NER [2].
  • The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage [2].
  • These observations suggest that the products of the CSA and CSB genes are involved in transcription [6].
  • We report the cloning of the CSA cDNA, which can encode a WD repeat protein [6].
  • Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patients' death in early adulthood [7].
 

Chemical compound and disease context of ERCC8

 

Biological context of ERCC8

 

Anatomical context of ERCC8

  • Here, we have analyzed repair in a CSA fibroblast strain [9].
  • In addition, the model can explain how various therapeutic agent correct CN and also provides insight into why other hematologic cell lines and CSA oscillate in CN [13].
  • RESULTS: The proportion (%) of CD4+IL-2+ lymphocytes corresponding to CSA levels (mean+/-SD ng/ml) measured preoperatively (TO=O), and on postoperative day 8, before (356+/-63), and 2 hr after the morning dose (Cmax=1567+/-669), decreased from 39+/-16 to 15+/-8 and 3+/-1.6, respectively [14].
  • One-year posttransplant, NK cell counts and NK cell cytotoxicity was significantly higher in patients receiving FK/MMF therapy, as compared to CSA/Aza [15].
  • [Granulocyte progenitor cells in peripheral blood and leucocyte CSA in patients with neutrophilic leucocytosis not due to haematological disease. A clinical study.] [16].
 

Associations of ERCC8 with chemical compounds

  • Residue-Specific (13)C' CSA Tensor Principal Components for Ubiquitin: Correlation between Tensor Components and Hydrogen Bonding [17].
  • BACKGROUND: Clinically, cyclosporine (CSA, Neoral) is titrated to concentrations, and not to pharmacological effect [14].
  • These patients were included in a randomized prospective open trial comparing tacrolimus/mycophenolate mofetil (FK/MMF) versus cyclosporine/azathioprine (CSA/Aza), both used in association with rabbit antithymocyte globulines (rATG) induction and prednisone [15].
  • The contribution of CSA to the increase in whey proteins in early milks was greater than that described in the bovine and caprine species [18].
  • CSAp was shown to be distinct from blood group antigens, including Lea and Leb blood group substances, liver ferritin, AFP, CEA, CSA, CMA, ZGM, and BOFA, and to have the electrophoretic mobility of an alpha2-globulin [19].
 

Other interactions of ERCC8

  • The transcription-repair coupling factor CSA is required for efficient repair only during the elongation stages of RNA polymerase II transcription [9].
 

Analytical, diagnostic and therapeutic context of ERCC8

References

  1. Rodent complementation group 8 (ERCC8) corresponds to Cockayne syndrome complementation group A. Itoh, T., Shiomi, T., Shiomi, N., Harada, Y., Wakasugi, M., Matsunaga, T., Nikaido, O., Friedberg, E.C., Yamaizumi, M. Mutat. Res. (1996) [Pubmed]
  2. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Groisman, R., Polanowska, J., Kuraoka, I., Sawada, J., Saijo, M., Drapkin, R., Kisselev, A.F., Tanaka, K., Nakatani, Y. Cell (2003) [Pubmed]
  3. Lateral sleeping position reduces severity of central sleep apnea / Cheyne-Stokes respiration. Szollosi, I., Roebuck, T., Thompson, B., Naughton, M.T. Sleep. (2006) [Pubmed]
  4. Detection and partial characterization of human B cell colony stimulating activity in synovial fluids of patients with rheumatoid arthritis. Fay, A.C., Trudgett, A., McCrea, J.D., Kirk, F., Thompson, J.M., Mitchell, E.S., Boyd, M.J., Roberts, S.D., McNeill, T.A. Clin. Exp. Immunol. (1985) [Pubmed]
  5. Field evaluation of the Computer Science and Applications, Inc. physical activity monitor. Sirard, J.R., Melanson, E.L., Li, L., Freedson, P.S. Medicine and science in sports and exercise. (2000) [Pubmed]
  6. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Henning, K.A., Li, L., Iyer, N., McDaniel, L.D., Reagan, M.S., Legerski, R., Schultz, R.A., Stefanini, M., Lehmann, A.R., Mayne, L.V., Friedberg, E.C. Cell (1995) [Pubmed]
  7. CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. Groisman, R., Kuraoka, I., Chevallier, O., Gaye, N., Magnaldo, T., Tanaka, K., Kisselev, A.F., Harel-Bellan, A., Nakatani, Y. Genes Dev. (2006) [Pubmed]
  8. Muromonab-CD3 (Orthoclone OKT3), methylprednisolone and cyclosporine for acute graft-versus-host disease prophylaxis in allogeneic bone marrow transplantation. Benekli, M., Hahn, T., Williams, B.T., Cooper, M., Roy, H.N., Wallace, P., Stewart, C., Bambach, B., McCarthy, P.L. Bone Marrow Transplant. (2006) [Pubmed]
  9. The transcription-repair coupling factor CSA is required for efficient repair only during the elongation stages of RNA polymerase II transcription. Tu, Y., Bates, S., Pfeifer, G.P. Mutat. Res. (1998) [Pubmed]
  10. CKN1 (MIM 216400): mutations in Cockayne syndrome type A and a new common polymorphism. Cao, H., Williams, C., Carter, M., Hegele, R.A. J. Hum. Genet. (2004) [Pubmed]
  11. Stable graft function after reduction of calcineurin inhibitor dosage in paediatric kidney transplant patients. Plank, C., Benz, K., Amann, K., Nüsken, K.D., Dittrich, K., Rascher, W., Sauerstein, K., Stuppy, A., Klare, B., Dötsch, J. Nephrol. Dial. Transplant. (2006) [Pubmed]
  12. Reversal of central sleep apnea using nasal CPAP. Issa, F.G., Sullivan, C.E. Chest (1986) [Pubmed]
  13. Cyclic neutropenia (CN): a clue to the control of granulopoiesis. von Schulthess, G.K., Mazer, N.A. Blood (1982) [Pubmed]
  14. Stimulated response of peripheral lymphocytes may distinguish cyclosporine effect in renal transplant recipients receiving a cyclosporine+rapamycin regimen. Sindhi, R., LaVia, M.F., Paulling, E., McMichael, J., Burckart, G., Shaw, S., Sindhi, L.A., Livingston, R., Sehgal, S., Jaffe, J. Transplantation (2000) [Pubmed]
  15. Tacrolimus/mycophenolate mofetil improved natural killer lymphocyte reconstitution one year after kidney transplant by reference to cyclosporine/azathioprine. Vacher-Coponat, H., Brunet, C., Moal, V., Loundou, A., Bonnet, E., Lyonnet, L., Ravet, S., Sampol-Manos, E., Sampol, J., Berland, Y., George, F.D., Paul, P. Transplantation (2006) [Pubmed]
  16. [Granulocyte progenitor cells in peripheral blood and leucocyte CSA in patients with neutrophilic leucocytosis not due to haematological disease. A clinical study.]. Morra, L., Ponassi, A., Gigli, G., Molinari, A., Sacchetti, C. Haematologica (1979) [Pubmed]
  17. Residue-Specific (13)C' CSA Tensor Principal Components for Ubiquitin: Correlation between Tensor Components and Hydrogen Bonding. Burton, R.A., Tjandra, N. J. Am. Chem. Soc. (2007) [Pubmed]
  18. Camel (Camelus dromedarius) immunoglobulin G, alpha-lactalbumin, serum albumin and lactoferrin in colostrum and milk during the early post partum period. El-Hatmi, H., Levieux, A., Levieux, D. J. Dairy Res. (2006) [Pubmed]
  19. Further characterization of CSAp, an antigen associated with gastrointestinal and ovarian tumors. Pant, K.D., Dahlman, H.L., Goldenberg, D.M. Cancer (1978) [Pubmed]
  20. Molecular cloning and characterization of Saccharomyces cerevisiae RAD28, the yeast homolog of the human Cockayne syndrome A (CSA) gene. Bhatia, P.K., Verhage, R.A., Brouwer, J., Friedberg, E.C. J. Bacteriol. (1996) [Pubmed]
  21. Variability of the 15N chemical shielding tensors in the B3 domain of protein g from 15N relaxation measurements at several fields. Implications for backbone order parameters. Hall, J.B., Fushman, D. J. Am. Chem. Soc. (2006) [Pubmed]
  22. The effects of immobilization, after lower leg fracture, on the contractile properties of human triceps surae. White, M.J., Davies, C.T. Clin. Sci. (1984) [Pubmed]
  23. Pleocytosis after hemopoietic stem cell transplantation. Nagashima, T., Muroi, K., Kawano-Yamamoto, C., Miyoshi, T., Tatara, R., Meguro, A., Fujiwara, S., Obara, Y., Oh, I., Kikuchi, S., Sato, K., Matsuyama, T., Toshima, M., Ohmine, K., Ozaki, K., Takatoku, M., Mori, M., Nagai, T., Ozawa, K. Leuk. Lymphoma (2006) [Pubmed]
 
WikiGenes - Universities