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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity.

Superoxide dismutase (SOD), a key enzyme in the detoxification of free radicals, catalyses the dismutation of superoxide O2.- to oxygen and hydrogen peroxide (H2O2). It is therefore a promising candidate for gene transfer therapy of neurological diseases in which free radicals are thought to be involved. We have constructed a recombinant adenoviral vector containing the human copper-zinc SOD cDNA. Using this vector we were able to drive the production of an active human copper-zinc SOD protein (hCuZnSOD) in various cell lines and primary cultures. Infection of striatal cells with a recombinant adenovirus expressing hCuZnSOD protected these cells from glutamate-induced cell death.[1]

References

  1. An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity. Barkats, M., Bemelmans, A.P., Geoffroy, M.C., Robert, J.J., Loquet, I., Horellou, P., Revah, F., Mallet, J. Neuroreport (1996) [Pubmed]
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