Lipoprotein lipase activity of post-heparin plasma in Japanese black cattle affected with fat necrosis.
Post-heparin plasma (PHP) lipoprotein lipase ( LPL) activity and serum lipoprotein concentration were examined in Japanese Black cows affected with fat necrosis. The PHP- LPL activity in the affected cows was significantly (P < 0.001) higher than in normal animals and tended to reduce 4 weeks after treatment with isoprothiolane. This finding indicates that affected cows have a predisposition to deposit more fat into adipose tissue than normal animals. The serum concentrations of triglyceride in beta-lipoprotein and of cholesterol, phospholipid and total lipid in alpha-lipoprotein were significantly (P < 0.05) lower in the affected cows. Elevated levels of phospholipid and total lipid in alpha-lipoprotein as well as decreased levels of non-esterified fatty acid (NEFA) were observed after medication. It is suggested that isoprothiolane produces an improvement in hepatic lipid metabolism including acceleration of plasma NEFA uptake and alpha-lipoprotein secretion in affected cows.[1]References
- Lipoprotein lipase activity of post-heparin plasma in Japanese black cattle affected with fat necrosis. Katamoto, H., Aoki, M., Shimada, Y., Hakogi, E. Br. Vet. J. (1996) [Pubmed]
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