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MeSH Review

Fat Necrosis

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Disease relevance of Fat Necrosis


High impact information on Fat Necrosis

  • (c) Albumin prevented the development of panlobular necrosis and lowered the degree of extrapancreatic fat necrosis [6].
  • The activity of lysosomal enzymes of the pancreas and the liver has been studied during induction and onset of acute hemorrhagic pancreatic necrosis with fat necrosis (AHPN) in mice [7].
  • Mice fed DL-ethionine with a choline-deficient diet develop a fatal acute hemorrhagic pancreatic necrosis with fat necrosis (AHPN) in 5 days [8].
  • In patients with suspected abscess formation following acute pancreatitis, indium leukocyte imaging does not differentiate between fat necrosis and abscess formation [9].
  • Membranous fat necrosis (MFN) is an under-recognized variant of fat necrosis (FN) that is characterized by the presence of membranocystic foci in which cysts are lined by an eosinophilic, homogeneous membrane with pseudo-papillary luminal projections [10].

Chemical compound and disease context of Fat Necrosis


Biological context of Fat Necrosis


Anatomical context of Fat Necrosis


Gene context of Fat Necrosis

  • Pseudomembranous fat necrosis labelled strongly for the histiocytic markers CD68 and lysozyme [20].
  • Supraumbilical dermal sclerosis and fat necrosis from chemoembolization of hepatocellular carcinoma [21].
  • There was a statistically significant correlation between endothelin-1 concentrations and Tgrad (Spearman non-linear correlation) (r = 0.32, P = 0.004) and between endothelin-1 and MAP (r = 0.25, P = 0.02), but not between endothelin-1 and HR or development of minor cutaneous or fat necrosis of the flap (five patients) [22].
  • MAIN OUTCOME MEASURES: Flap loss, fat necrosis, flap volume loss, adjuvant treatment delay, and need for additional surgery [23].
  • A preoperative delay procedure can decrease the likelihood of TRAM flap failure or fat necrosis, but the required extent of this delay procedure is not clearly defined [24].

Analytical, diagnostic and therapeutic context of Fat Necrosis


  1. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Lombardi, B., Estes, L.W., Longnecker, D.S. Am. J. Pathol. (1975) [Pubmed]
  2. Liver failure with steatonecrosis after jejunoileal bypass: recovery with parenteral nutriton and reanastomosis. Baker, A.L., Elson, C.O., Jaspan, J., Boyer, J.L. Arch. Intern. Med. (1979) [Pubmed]
  3. alpha 1-antitrypsin deficiency-associated panniculitis: resolution with intravenous alpha 1-antitrypsin administration and liver transplantation. O'Riordan, K., Blei, A., Rao, M.S., Abecassis, M. Transplantation (1997) [Pubmed]
  4. Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis. Kruse, K., Irle, U., Uhlig, R. J. Pediatr. (1993) [Pubmed]
  5. Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats. Orfila, C., Lepert, J.C., Alric, L., Carrera, G., Béraud, M., Pipy, B. Histochem. Cell Biol. (2005) [Pubmed]
  6. Comparison of different treatment modalities in experimental pancreatitis in rats. Kimura, W., Meyer, F., Hess, D., Kirchner, T., Fischbach, W., Mössner, J. Gastroenterology (1992) [Pubmed]
  7. Acute hemorrhagic pancreatic necrosis in mice: the activity of lysosomal enzymes in the pancreas and the liver. Rao, K.N., Zuretti, M.F., Baccino, F.M., Lombardi, B. Am. J. Pathol. (1980) [Pubmed]
  8. Influence of dietary factors on the pancreatotoxicity of ethionine. Lombardi, B. Am. J. Pathol. (1976) [Pubmed]
  9. Indium-111 autologous leukocyte imaging in pancreatitis. Anderson, J.R., Spence, R.A., Laird, J.D., Ferguson, W.R., Kennedy, T.L. J. Nucl. Med. (1986) [Pubmed]
  10. Membranous fat necrosis in lipomas. Ramdial, P.K., Madaree, A., Singh, B. Am. J. Surg. Pathol. (1997) [Pubmed]
  11. Fat necrosis from intramuscular aurothioglucose. Sowa, J.M. J. Rheumatol. (1994) [Pubmed]
  12. Low-molecular-weight heparin-associated fat necrosis of the breast. Das, A.K. Age and ageing. (2005) [Pubmed]
  13. Mammographic appearance of coumadin-induced fat necrosis. Baker, K.S., Stelling, C.B. AJR. American journal of roentgenology. (1992) [Pubmed]
  14. Association of blood cholesterol with occurrence of fat necrosis in cows and tall fescue summer toxicosis in steers. Stuedemann, J.A., Rumsey, T.S., Bond, J., Wilkinson, S.R., Bush, L.P., Williams, D.J., Caudle, A.B. Am. J. Vet. Res. (1985) [Pubmed]
  15. Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats. Yagci, G., Gul, H., Simsek, A., Buyukdogan, V., Onguru, O., Zeybek, N., Aydin, A., Balkan, M., Yildiz, O., Sen, D. J. Gastroenterol. (2004) [Pubmed]
  16. Increased apoptosis of periprostatic adipose tissue in VDR null mice. Guzey, M., Jukic, D., Arlotti, J., Acquafondata, M., Dhir, R., Getzenberg, R.H. J. Cell. Biochem. (2004) [Pubmed]
  17. Calcifications in axillary lymph nodes caused by fat necrosis, redux. Gold, R.H., Bassett, L.W. AJR. American journal of roentgenology. (1997) [Pubmed]
  18. Late results of breast reconstruction with free TRAM flaps: a prospective multicentric study. Banic, A., Boeckx, W., Greulich, M., Guelickx, P., Marchi, A., Rigotti, G., Tschopp, H. Plast. Reconstr. Surg. (1995) [Pubmed]
  19. Fluorescence histochemical study of the pancreas in the cat. Onda, M. Gastroenterol. Jpn. (1976) [Pubmed]
  20. Subcutaneous pseudomembranous fat necrosis: new observations. Diaz-Cascajo, C., Borghi, S. J. Cutan. Pathol. (2002) [Pubmed]
  21. Supraumbilical dermal sclerosis and fat necrosis from chemoembolization of hepatocellular carcinoma. Baysal, T., D'Agostino, H.B., Serra, E.E., Valji, K., Rose, S.C., Kinney, T.B. Journal of vascular and interventional radiology : JVIR. (1998) [Pubmed]
  22. Perioperative plasma endothelin-1 concentrations and vasoconstriction during prolonged plastic surgical procedures. Tuominen, H.P., Svartling, N.E., Tikkanen, I.T., Saijonmaa, O., Asko-Seljavaara, S. British journal of anaesthesia. (1995) [Pubmed]
  23. Safety of immediate transverse rectus abdominis myocutaneous breast reconstruction for patients with locally advanced disease. Foster, R.D., Hansen, S.L., Esserman, L.J., Hwang, E.S., Ewing, C., Lane, K., Anthony, J.P. Archives of surgery (Chicago, Ill. : 1960) (2005) [Pubmed]
  24. TRAM flap perforator ligation and the delay phenomenon: development of an endoscopic/laparoscopic delay procedure. Restifo, R.J., Ahmed, S.S., Rosser, J., Zahir, K., Zink, J., Lalikos, J.A., Thomson, J.G. Plast. Reconstr. Surg. (1998) [Pubmed]
  25. Pancreatic damage produced by injecting excess lysine in rats. Kitajima, S., Kishino, Y. Virchows Arch., B, Cell Pathol. (1985) [Pubmed]
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