Disease relevance of Fat Necrosis

• Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet [1].
• Liver failure with steatonecrosis after jejunoileal bypass: recovery with parenteral nutriton and reanastomosis [2].
• Panniculitis is a rare complication of alpha 1-antitrypsin (A1AT) deficiency that is characterized by acute inflammatory infiltrate and fat necrosis [3].
• Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia [4].
• We investigated the immunohistochemical distribution of active NF-kappaB p65 and peroxisome proliferator-activated receptor (PPAR) subtypes alpha and gamma in the different phases of liver steatonecrosis and cirrhosis induced in rats after 3 and 9 weeks of carbon tetrachloride (CCl4) intoxication [5].

High impact information on Fat Necrosis

• (c) Albumin prevented the development of panlobular necrosis and lowered the degree of extrapancreatic fat necrosis [6].
• The activity of lysosomal enzymes of the pancreas and the liver has been studied during induction and onset of acute hemorrhagic pancreatic necrosis with fat necrosis (AHPN) in mice [7].
• Mice fed DL-ethionine with a choline-deficient diet develop a fatal acute hemorrhagic pancreatic necrosis with fat necrosis (AHPN) in 5 days [8].
• In patients with suspected abscess formation following acute pancreatitis, indium leukocyte imaging does not differentiate between fat necrosis and abscess formation [9].
• Membranous fat necrosis (MFN) is an under-recognized variant of fat necrosis (FN) that is characterized by the presence of membranocystic foci in which cysts are lined by an eosinophilic, homogeneous membrane with pseudo-papillary luminal projections [10].

Chemical compound and disease context of Fat Necrosis

• Fat necrosis from intramuscular aurothioglucose [11].
• Low-molecular-weight heparin-associated fat necrosis of the breast [12].
• Mammographic appearance of coumadin-induced fat necrosis [13].
• Association of blood cholesterol with occurrence of fat necrosis in cows and tall fescue summer toxicosis in steers [14].
• RESULTS: Rats with AP had extensive parenchymal and fat necrosis and NAC treatment at 12 h reduced tissue necrosis significantly (P < 0.05) [15].

Biological context of Fat Necrosis

• Although, there were no gross differences between the prostate tissue of the experimental and control groups, VDR null mice showed fat necrosis and individual cell apoptosis in the periprostatic adipose tissue [16].

Anatomical context of Fat Necrosis

• Calcifications in axillary lymph nodes caused by fat necrosis, redux [17].
• However, we have experienced several complications after free TRAM flaps in our practice, including fat necrosis, partial and complete flap necrosis, abdominal-wall weakness, and hernias [18].
• 1) After seven days of ethionine (5 mg/kg BW oral ad.) treatment, pancreas showed histochemical changes such as hemorrhage, fat necrosis, destruction of acinar cells and degranulation of zymogen from the parenchyma of pancreas [19].

Gene context of Fat Necrosis

• Pseudomembranous fat necrosis labelled strongly for the histiocytic markers CD68 and lysozyme [20].
• Supraumbilical dermal sclerosis and fat necrosis from chemoembolization of hepatocellular carcinoma [21].
• There was a statistically significant correlation between endothelin-1 concentrations and Tgrad (Spearman non-linear correlation) (r = 0.32, P = 0.004) and between endothelin-1 and MAP (r = 0.25, P = 0.02), but not between endothelin-1 and HR or development of minor cutaneous or fat necrosis of the flap (five patients) [22].
• MAIN OUTCOME MEASURES: Flap loss, fat necrosis, flap volume loss, adjuvant treatment delay, and need for additional surgery [23].
• A preoperative delay procedure can decrease the likelihood of TRAM flap failure or fat necrosis, but the required extent of this delay procedure is not clearly defined [24].

Analytical, diagnostic and therapeutic context of Fat Necrosis

• Intraperitoneal injection of lysine (400 mg/100 g body weight) in rats caused necrosis of pancreatic acinar cells with fat necrosis and a significant increase in serum amylase and lipase [25].

References