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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Vaginal prostaglandin E2 for missed abortion and intrauterine fetal death.

Vaginal suppositories containing 20 mg. of prostaglandin E2 (PGE2) were given to 50 patients with a diagnosis of either missed abortion or fetal death. A total of 94 percent of the patients (47/50) expelled products of conception, and 84 percent of these expulsions (42/50) were complete. The mean time to expulsion of the fetus was 11.3 hours with a mean dose of 3.6 suppositiries. A total 60 per cent of the patients experienced vomiting, diarrhea, and pyrexia. Four patients had a blood loss in excess of 500 ml., and two of these patients required blood transfusion. Vaginal administration of PGE2 suppositories appeared to be a rapid, safe, and reliable means of managing missed abortion and intrauterine fetal death.[1]


  1. Vaginal prostaglandin E2 for missed abortion and intrauterine fetal death. Rutland, A., Ballard, C. Am. J. Obstet. Gynecol. (1977) [Pubmed]
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