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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hu, R. et al.

HIV-1 gp160 induces transforming growth factor-beta production in human PBMC.

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine secreted by many mononuclear cells in peripheral blood (PBMC) and has diverse effects on cellular and humoral immunity. Increased TGF-beta mRNA expression has been reported in PBMC of HIV-infected patients, but the mechanism by which HIV induces TGF-beta secretion is unknown. In this study, we observed that HIV gp160 could induce significant TGF-beta secretion and TGF-beta mRNA expression in PBMC from HIV-seronegative healthy donors. The cellular source of TGF-beta was attributed to non-T cells, presumably monocytes. Specificity of secreted TGF-beta was confirmed by the addition of anti-TGF-beta mAb which abrogated the proliferative response of CCL-64 cells by gp160-treated culture supernatants. Soluble CD4 blocked the gp160- induced TGF-beta production, suggesting that CD4-gp160 interaction is required to induce TGF-beta production. Our results suggest that HIV-1 gp160 may contribute to the immune defects in HIV infection by inducing TGF-beta secretion.[1]

References

HIV-1 gp160 induces transforming growth factor-beta production in human PBMC. Hu, R., Oyaizu, N., Than, S., Kalyanaraman, V.S., Wang, X.P., Pahwa, S. Clin. Immunol. Immunopathol. (1996) [Pubmed]

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