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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The neurotensin receptor antagonist SR 48692 decreases extracellular striatal GABA in rats.

Intracranial microdialysis was utilized to assess the effects of the novel neurotensin antagonist SR 48692 on extracellular gamma-amino-butyric acid (GABA) and glycine in the striatum. Subcutaneous injection of SR 48692 (0.2 mg/kg) significantly decreased extracellular striatal GABA levels, with peak decreases occurring 2-3 h post-injection. Injection of SR 48692 had no significant effect on glycine levels. These data suggest that endogenous neurotensin may modulate striatal GABA levels.[1]


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