Chemical Compound Review:
Reminertant 2-[[1-(7-chloroquinolin-4- yl)-5-(2,6...
Synonyms:
Meclinertant, CHEMBL506981, cc-385, SureCN1650932, QC-4586, ...
- Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Gully, D., Canton, M., Boigegrain, R., Jeanjean, F., Molimard, J.C., Poncelet, M., Gueudet, C., Heaulme, M., Leyris, R., Brouard, A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Neurotensin and a non-peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice. Maoret, J.J., Anini, Y., Rouyer-Fessard, C., Gully, D., Laburthe, M. Int. J. Cancer (1999)
- Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats. Poncelet, M., Souilhac, J., Gueudet, C., Terranova, J.P., Gully, D., Le Fur, G., Soubrié, P. Psychopharmacology (Berl.) (1994)
- Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. McCormick, S.E., Stoessl, A.J. Neuroscience (2003)
- SR48692 is a neurotensin receptor antagonist which inhibits the growth of small cell lung cancer cells. Moody, T.W., Chiles, J., Casibang, M., Moody, E., Chan, D., Davis, T.P. Peptides (2001)
- Chronic blockade of neurotensin receptors strongly reduces sensitized, but not acute, behavioral response to D-amphetamine. Panayi, F., Dorso, E., Lambás-Señas, L., Renaud, B., Scarna, H., Bérod, A. Neuropsychopharmacology (2002)
- A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. Castagliuolo, I., Leeman, S.E., Bartolak-Suki, E., Nikulasson, S., Qiu, B., Carraway, R.E., Pothoulakis, C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Neurotensin and the serotonergic system. Jolas, T., Aghajanian, G.K. Prog. Neurobiol. (1997)
- Differential binding profile and internalization process of neurotensin via neuronal and glial receptors. Nouel, D., Faure, M.P., St Pierre, J.A., Alonso, R., Quirion, R., Beaudet, A. J. Neurosci. (1997)
- Blockade of neurotensin receptors affects differently hypo-locomotion and catalepsy induced by haloperidol in mice. Casti, P., Marchese, G., Casu, G., Ruiu, S., Pani, L. Neuropharmacology (2004)
- Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. Gully, D., Labeeuw, B., Boigegrain, R., Oury-Donat, F., Bachy, A., Poncelet, M., Steinberg, R., Suaud-Chagny, M.F., Santucci, V., Vita, N., Pecceu, F., Labbé-Jullié, C., Kitabgi, P., Soubrié, P., Le Fur, G., Maffrand, J.P. J. Pharmacol. Exp. Ther. (1997)
- Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil. Urban, M.O., Jiang, M.C., Gebhart, G.F. Brain Res. (1996)
- Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist. Labbé-Jullié, C., Barroso, S., Nicolas-Etève, D., Reversat, J.L., Botto, J.M., Mazella, J., Bernassau, J.M., Kitabgi, P. J. Biol. Chem. (1998)
- Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin. Croci, T., Giudice, A., Manara, L., Gully, D., Le Fur, G. Br. J. Pharmacol. (1995)
- Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling. Matsuyama, S., Fukui, R., Higashi, H., Nishi, A. Eur. J. Neurosci. (2003)
- Endogenous neurotensin down-regulates dopamine efflux in the nucleus accumbens as revealed by SR-142948A, a selective neurotensin receptor antagonist. Brun, P., Leonetti, M., Sotty, F., Steinberg, R., Soubrié, P., Renaud, B., Suaud-Chagny, M.F. J. Neurochem. (2001)
- Repeated administration of the neurotensin receptor antagonist SR 48692 differentially regulates mesocortical and mesolimbic dopaminergic systems. Azzi, M., Betancur, C., Sillaber, I., Spangel, R., Rostène, W., Bérod, A. J. Neurochem. (1998)
- Blockade of mast cell histamine secretion in response to neurotensin by SR 48692, a nonpeptide antagonist of the neurotensin brain receptor. Miller, L.A., Cochrane, D.E., Carraway, R.E., Feldberg, R.S. Br. J. Pharmacol. (1995)
- Effect of the nonpeptide neurotensin antagonist, SR 48692, and two enantiomeric analogs, SR 48527 and SR 49711, on neurotensin binding and contractile responses in guinea pig ileum and colon. Labbé-Jullié, C., Deschaintres, S., Gully, D., Le Fur, G., Kitabgi, P. J. Pharmacol. Exp. Ther. (1994)
- Human umbilical vein endothelial cells express high affinity neurotensin receptors coupled to intracellular calcium release. Schaeffer, P., Laplace, M.C., Savi, P., Pflieger, A.M., Gully, D., Herbert, J.M. J. Biol. Chem. (1995)
- Placebo-controlled evaluation of four novel compounds for the treatment of schizophrenia and schizoaffective disorder. Meltzer, H.Y., Arvanitis, L., Bauer, D., Rein, W. The American journal of psychiatry. (2004)
- Characterization of the profile of neurokinin-2 and neurotensin receptor antagonists in the mouse defense test battery. Griebel, G., Moindrot, N., Aliaga, C., Simiand, J., Soubrié, P. Neuroscience and biobehavioral reviews. (2001)
- Blockade of neurotensin receptor by SR 48692 potentiates the facilitatory effect of haloperidol on the evoked in vivo dopamine release in the rat nucleus accumbens. Brun, P., Steinberg, R., Le Fur, G., Soubrié, P. J. Neurochem. (1995)
- Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. Poinot-Chazel, C., Portier, M., Bouaboula, M., Vita, N., Pecceu, F., Gully, D., Monroe, J.G., Maffrand, J.P., Le Fur, G., Casellas, P. Biochem. J. (1996)
- Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor. Leplatois, P., Josse, A., Guillemot, M., Febvre, M., Vita, N., Ferrara, P., Loison, G. Eur. J. Biochem. (2001)
- Blockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain. Alonso, R., Gnanadicom, H., Fréchin, N., Fournier, M., Le Fur, G., Soubrié, P. Eur. J. Neurosci. (1999)
- Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma. Kim, H.S., Yumkham, S., Choi, J.H., Lee, S.H., Kim, T.H., Ryu, S.H., Suh, P.G. Neuropeptides (2006)
- Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive. Buhler, A.V., Choi, J., Proudfit, H.K., Gebhart, G.F. Pain (2005)
- The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes. Dubuc, I., Costentin, J., Terranova, J.P., Barnouin, M.C., Soubrié, P., Le Fur, G., Rostène, W., Kitabgi, P. Br. J. Pharmacol. (1994)
- Differential effects of intrastriatal neurotensin(1-13) and neurotensin(8-13) on striatal dopamine and pallidal GABA release. A dual-probe microdialysis study in the awake rat. Ferraro, L., O'Connor, W.T., Antonelli, T., Fuxe, K., Tanganelli, S. Eur. J. Neurosci. (1997)
- The neurotensin receptor antagonist SR 48692 decreases extracellular striatal GABA in rats. Chapman, M.A., See, R.E. Brain Res. (1996)