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Gene Review

Nts  -  neurotensin

Rattus norvegicus

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Disease relevance of Nts


Psychiatry related information on Nts


High impact information on Nts


Chemical compound and disease context of Nts


Biological context of Nts


Anatomical context of Nts


Associations of Nts with chemical compounds

  • Our results showed that a lesion of the nigrostriatal pathway induced the expression of enkephalin, neurotensin, and substance P immunoreactivity in numerous pallidal cell bodies [24].
  • Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons [27].
  • Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats [28].
  • Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated acid secretion in rats [29].
  • The distributions of the top 20% of the terminal density range of NT, SP, AII and VIP support a classical medial/lateral division of the nucleus [30].

Physical interactions of Nts


Co-localisations of Nts

  • Another subpopulation comprised larger neurons that exhibited intense neurotensin immunoreactivity in perikarya and proximal processes that was rarely co-localized with Fos immunoreactivity [35].

Regulatory relationships of Nts


Other interactions of Nts

  • A significant percentage of CRF (54-66%)-, NT (40-53%)-, and SS (31-50%)-immunoreactive neurons were retrogradely labeled, predominantly within the lateral CNA [25].
  • The distribution of NT-containing fibers was similar to the pattern of CCK-containing fibers and these were localized primarily to the central zone of the PBL [41].
  • Numerous L-ENK-immunoreactive cell bodies, and moderate numbers of CCK-, NT-, and CRF-stained cell bodies were found in the AVPv [42].
  • In conclusion, estrogens play a facilitatory role on NT-induced GH release in the rat, which is exerted through a mechanism independent of hypothalamic GHRH or somatostatin release [43].
  • Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain [44].

Analytical, diagnostic and therapeutic context of Nts


  1. Complementary distribution of receptors for neurotensin and NPY in small neurons in rat lumbar DRGs and regulation of the receptors and peptides after peripheral axotomy. Zhang, X., Xu, Z.Q., Bao, L., Dagerlind, A., Hökfelt, T. J. Neurosci. (1995) [Pubmed]
  2. The effect of centrally administered neuropeptides on the development of stress-induced gastric ulcers in rats. Hernandez, D.E., Nemeroff, C.B., Orlando, R.C., Prange, A.J. J. Neurosci. Res. (1983) [Pubmed]
  3. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. Beck, B., Burlet, A., Nicolas, J.P., Burlet, C. J. Nutr. (1990) [Pubmed]
  4. Neuropeptides and thermoregulation: the interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins. Morley, J.E., Levine, A.S., Oken, M.M., Grace, M., Kneip, J. Peptides (1982) [Pubmed]
  5. Effect of acute and daily neurotensin and enkephalin treatments on extracellular dopamine in the nucleus accumbens. Kalivas, P.W., Duffy, P. J. Neurosci. (1990) [Pubmed]
  6. Mediation by neurotensin-receptors of effects of neurotensin on self-stimulation of the medial prefrontal cortex. Fernández, R., Sabater, R., Sáez, J.A., Montes, R., Alba, F., Ferrer, J.M. Br. J. Pharmacol. (1996) [Pubmed]
  7. Ventral tegmental area infusion of substance P, neurotensin and enkephalin: differential effects on feeding behavior. Cador, M., Kelley, A.E., Le Moal, M., Stinus, L. Neuroscience (1986) [Pubmed]
  8. Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat. Kalivas, P.W., Burgess, S.K., Nemeroff, C.B., Prange, A.J. Neuroscience (1983) [Pubmed]
  9. Neurotensin attenuates the reduction in alcohol drinking produced by angiotensin II. Grupp, L.A., Harding, S. Psychopharmacology (Berl.) (1996) [Pubmed]
  10. Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra. Uhl, G.R., Kuhar, M.J. Nature (1984) [Pubmed]
  11. Neurotensin in the rat anterior pituitary gland. Goedert, M., Lightman, S.L., Nagy, J.I., Marley, P.D., Emson, P.C. Nature (1982) [Pubmed]
  12. Neurotensin receptors are located on dopamine-containing neurones in rat midbrain. Palacios, J.M., Kuhar, M.J. Nature (1981) [Pubmed]
  13. Neurotensin blocks certain amphetamine-induced behaviours. Ervin, G.N., Birkemo, L.S., Nemeroff, C.B., Prange, A.J. Nature (1981) [Pubmed]
  14. Higher level organization of individual gene transcription and RNA splicing. Xing, Y., Johnson, C.V., Dobner, P.R., Lawrence, J.B. Science (1993) [Pubmed]
  15. Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells. Kislauskis, E., Dobner, P.R. Neuron (1990) [Pubmed]
  16. Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats. Zhang, L., Xing, L.P., Demers, L., Washington, J., Kauffman, G.L. Gastroenterology (1989) [Pubmed]
  17. Promotion by neurotensin of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Baba, M., Taniguchi, H. Cancer Res. (1989) [Pubmed]
  18. Effects of neurotensin and substance P on plasma insulin, glucagon and glucose levels. Brown, M., Vale, W. Endocrinology (1976) [Pubmed]
  19. Neurotensin excitation of rat ventral tegmental neurones. Jiang, Z.G., Pessia, M., North, R.A. J. Physiol. (Lond.) (1994) [Pubmed]
  20. Phenotypical characterization of the rat striatal neurons expressing muscarinic receptor genes. Bernard, V., Normand, E., Bloch, B. J. Neurosci. (1992) [Pubmed]
  21. Effects of intraventricular administration of neurotensin and somatostatin on thermoregulation in the rat. Chandra, A., Chou, H.C., Chang, C., Lin, M.T. Neuropharmacology (1981) [Pubmed]
  22. Rat kidney endopeptidase 24.16. Purification, physico-chemical characteristics and differential specificity towards opiates, tachykinins and neurotensin-related peptides. Barelli, H., Vincent, J.P., Checler, F. Eur. J. Biochem. (1993) [Pubmed]
  23. Oral neurotensin increases gastrointestinal transit in suckling rats. Tomomasa, T., Itoh, K., Hyman, P.E., Kuroume, T. J. Pediatr. Gastroenterol. Nutr. (1991) [Pubmed]
  24. Enkephalin, neurotensin, and substance P immunoreactivite neurones of the rat GP following 6-hydroxydopamine lesion of the substantia nigra. Martorana, A., Fusco, F.R., D'Angelo, V., Sancesario, G., Bernardi, G. Exp. Neurol. (2003) [Pubmed]
  25. Evidence for corticotropin-releasing factor, neurotensin, and somatostatin in the neural pathway from the central nucleus of the amygdala to the parabrachial nucleus. Moga, M.M., Gray, T.S. J. Comp. Neurol. (1985) [Pubmed]
  26. Presence of somatostatin or neurotensin in lateral septal dopaminergic axon terminals of distinct hypothalamic and midbrain origins: convergence on the somatospiny neurons. Jakab, R.L., Leranth, C. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1993) [Pubmed]
  27. Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons. Farkas, R.H., Chien, P.Y., Nakajima, S., Nakajima, Y. Neurosci. Lett. (1997) [Pubmed]
  28. Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats. Smits, S.M., Terwisscha van Scheltinga, A.F., van der Linden, A.J., Burbach, J.P., Smidt, M.P. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  29. Somatostatin as a mediator of the effect of neurotensin on pentagastrin-stimulated acid secretion in rats. Hammer, R.A., Ochoa, A., Fernandez, C., Ertan, A., Arimura, A. Peptides (1992) [Pubmed]
  30. Computer-assisted image analysis of the distributions of peptidergic terminals in the central nucleus of the amygdala: a preliminary study. Cassell, M.D., Mankovich, N.J., Gray, T.S., Williams, T.H. Peptides (1982) [Pubmed]
  31. Identification of residues involved in neurotensin binding and modeling of the agonist binding site in neurotensin receptor 1. Barroso, S., Richard, F., Nicolas-Ethève, D., Reversat, J.L., Bernassau, J.M., Kitabgi, P., Labbé-Jullié, C. J. Biol. Chem. (2000) [Pubmed]
  32. Neurotensin increases tyrosine hydroxylase messenger RNA-positive neurons in substantia nigra after retrograde axonal transport. Burgevin, M.C., Castel, M.N., Quarteronet, D., Chevet, T., Laduron, P.M. Neuroscience (1992) [Pubmed]
  33. Subsets of neurotensin-immunoreactive neurons in the rat striatal complex following antagonism of the dopamine D2 receptor: an immunohistochemical double-labeling study using antibodies against Fos. Senger, B., Brog, J.S., Zahm, D.S. Neuroscience (1993) [Pubmed]
  34. Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo [125I]Tyr3-neurotensin. Moyse, E., Rostène, W., Vial, M., Leonard, K., Mazella, J., Kitabgi, P., Vincent, J.P., Beaudet, A. Neuroscience (1987) [Pubmed]
  35. Morphology and Fos immunoreactivity reveal two subpopulations of striatal neurotensin neurons following acute 6-hydroxydopamine lesions and reserpine administration. Brog, J.S., Zahm, D.S. Neuroscience (1995) [Pubmed]
  36. Excessive grooming induced by somatostatin or its analog SMS 201-995. Van Wimersma Greidanus, T.B., Maigret, C., Krechting, B. Eur. J. Pharmacol. (1987) [Pubmed]
  37. Stimulation by thyrotropin-releasing hormone of vagal outflow to the thyroid gland. Tonoue, T. Regul. Pept. (1982) [Pubmed]
  38. Effect of neurotensin on insulin, glucagon, and somatostatin release from isolated pancreatic islets. Dolais-Kitabgi, J., Kitabgi, P., Brazeau, P., Freychet, P. Endocrinology (1979) [Pubmed]
  39. Involvement of arachidonate metabolism in neurotensin-induced prolactin release in vitro. Canonico, P.L., Speciale, C., Sortino, M.A., Scapagnini, U. Am. J. Physiol. (1985) [Pubmed]
  40. Involvement of spinal cholecystokininB receptors in mediating neurotensin hyperalgesia from the medullary nucleus raphe magnus in the rat. Urban, M.O., Smith, D.J., Gebhart, G.F. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  41. Neuropeptide and monoamine components of the parabrachial pontine complex. Block, C.H., Hoffman, G.E. Peptides (1987) [Pubmed]
  42. The distribution of neurotransmitter-specific cells and fibers in the anteroventral periventricular nucleus: implications for the control of gonadotropin secretion in the rat. Simerly, R.B., Swanson, L.W. Brain Res. (1987) [Pubmed]
  43. Effect of neurotensin on growth hormone release in vivo. Ibañez, R., Mallo, F., Benitez, L., Alvarez, C.V., Sanchez-Franco, F., Dieguez, C. Life Sci. (1993) [Pubmed]
  44. Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain. Zhang, R.X., Mi, Z.P., Qiao, J.T. Regul. Pept. (1994) [Pubmed]
  45. Neurotensin stimulates histamine release in in vivo skin 'blisters' in rats: an effect inhibited by cromolyn or somatostatin. Cochrane, D.E., Boucher, W., Bibb, P. Int. Arch. Allergy Appl. Immunol. (1986) [Pubmed]
  46. A survey of substance P, somatostatin, and neurotensin levels in aging in the rat and human central nervous system. Buck, S.H., Deshmukh, P.P., Burks, T.F., Yamamura, H.I. Neurobiol. Aging (1981) [Pubmed]
  47. Effect of intraventricular injection of neurotensin and other various bioactive peptides on plasma immunoreactive somatostatin levels in rat hypophysial portal blood. Abe, H., Chihara, K., Chiba, T., Matsukura, S., Fujita, T. Endocrinology (1981) [Pubmed]
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