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Gene Review

Ntsr1  -  neurotensin receptor 1

Rattus norvegicus

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Disease relevance of Ntsr1

 

Psychiatry related information on Ntsr1

  • The restoration effect on scopolamine-induced amnesia produced by PD149163 was blocked by SR142948A, a nonselective neurotensin receptor antagonist, at a dose of 1 mg/kg (intraperitonial) but not at 0.1 mg/kg [6].
 

High impact information on Ntsr1

 

Chemical compound and disease context of Ntsr1

 

Biological context of Ntsr1

 

Anatomical context of Ntsr1

 

Associations of Ntsr1 with chemical compounds

 

Physical interactions of Ntsr1

 

Regulatory relationships of Ntsr1

 

Other interactions of Ntsr1

 

Analytical, diagnostic and therapeutic context of Ntsr1

References

  1. Somatodendritic internalization and perinuclear targeting of neurotensin in the mammalian brain. Faure, M.P., Alonso, A., Nouel, D., Gaudriault, G., Dennis, M., Vincent, J.P., Beaudet, A. J. Neurosci. (1995) [Pubmed]
  2. Identification of residues involved in neurotensin binding and modeling of the agonist binding site in neurotensin receptor 1. Barroso, S., Richard, F., Nicolas-Ethève, D., Reversat, J.L., Bernassau, J.M., Kitabgi, P., Labbé-Jullié, C. J. Biol. Chem. (2000) [Pubmed]
  3. Thr-422 and Tyr-424 residues in the carboxyl terminus are critical for the internalization of the rat neurotensin receptor. Chabry, J., Botto, J.M., Nouel, D., Beaudet, A., Vincent, J.P., Mazella, J. J. Biol. Chem. (1995) [Pubmed]
  4. Expression of a rat neurotensin receptor in Escherichia coli. Grisshammer, R., Duckworth, R., Henderson, R. Biochem. J. (1993) [Pubmed]
  5. Evidence for the dual coupling of the rat neurotensin receptor with pertussis toxin-sensitive and insensitive G-proteins. Gailly, P., Najimi, M., Hermans, E. FEBS Lett. (2000) [Pubmed]
  6. Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Azmi, N., Norman, C., Spicer, C.H., Bennett, G.W. Behavioural pharmacology. (2006) [Pubmed]
  7. Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra. Uhl, G.R., Kuhar, M.J. Nature (1984) [Pubmed]
  8. Structure and functional expression of the cloned rat neurotensin receptor. Tanaka, K., Masu, M., Nakanishi, S. Neuron (1990) [Pubmed]
  9. Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression. Tyler, B.M., Jansen, K., McCormick, D.J., Douglas, C.L., Boules, M., Stewart, J.A., Zhao, L., Lacy, B., Cusack, B., Fauq, A., Richelson, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  10. Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra. Boudin, H., Pélaprat, D., Rostène, W., Pickel, V.M., Beaudet, A. J. Neurosci. (1998) [Pubmed]
  11. Central administration of the neurotensin receptor antagonist SR48692 attenuates vacuous chewing movements in a rodent model of tardive dyskinesia. McCormick, S.E., Stoessl, A.J. Neuroscience (2003) [Pubmed]
  12. Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. Najimi, M., Maloteaux, J.M., Hermans, E. FEBS Lett. (2002) [Pubmed]
  13. Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. Hermans, E., Maloteaux, J.M., Octave, J.N. Brain Res. Mol. Brain Res. (1992) [Pubmed]
  14. Mutagenesis and modeling of the neurotensin receptor NTR1. Identification of residues that are critical for binding SR 48692, a nonpeptide neurotensin antagonist. Labbé-Jullié, C., Barroso, S., Nicolas-Etève, D., Reversat, J.L., Botto, J.M., Mazella, J., Bernassau, J.M., Kitabgi, P. J. Biol. Chem. (1998) [Pubmed]
  15. Chimeric rat/human neurotensin receptors localize a region of the receptor sensitive to binding of a novel, species-specific, picomolar affinity peptide. Cusack, B., Groshan, K., McCormick, D.J., Pang, Y.P., Perry, R., Phung, C.T., Souder, T., Richelson, E. J. Biol. Chem. (1996) [Pubmed]
  16. Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells. Yamada, M., Yamada, M., Watson, M.A., Richelson, E. Mol. Pharmacol. (1994) [Pubmed]
  17. Crucial role of neuron-enriched endosomal protein of 21 kDa in sorting between degradation and recycling of internalized G-protein-coupled receptors. Debaigt, C., Hirling, H., Steiner, P., Vincent, J.P., Mazella, J. J. Biol. Chem. (2004) [Pubmed]
  18. Lack of rapid desensitization of Ca2+ responses in transfected CHO cells expressing the rat neurotensin receptor despite agonist-induced internalization. Hermans, E., Gailly, P., Gillis, J.M., Octave, J.N., Maloteaux, J.M. J. Neurochem. (1995) [Pubmed]
  19. Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra. Bolden-Watson, C., Watson, M.A., Murray, K.D., Isackson, P.J., Richelson, E. J. Neurochem. (1993) [Pubmed]
  20. The rat neurotensin receptor expressed in Chinese hamster ovary cells mediates the release of inositol phosphates. Watson, M.A., Yamada, M., Yamada, M., Cusack, B., Veverka, K., Bolden-Watson, C., Richelson, E. J. Neurochem. (1992) [Pubmed]
  21. Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms, and internalization. Chabry, J., Labbé-Jullié, C., Gully, D., Kitabgi, P., Vincent, J.P., Mazella, J. J. Neurochem. (1994) [Pubmed]
  22. The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop. Ferraro, L., Antonelli, T., O'Connor, W.T., Fuxe, K., Soubrié, P., Tanganelli, S. J. Neurosci. (1998) [Pubmed]
  23. Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity. Antonelli, T., Ferraro, L., Fuxe, K., Finetti, S., Fournier, J., Tanganelli, S., De Mattei, M., Tomasini, M.C. Cereb. Cortex (2004) [Pubmed]
  24. Rapid agonist-induced decrease of neurotensin receptors from the cell surface in rat cultured neurons. Vanisberg, M.A., Maloteaux, J.M., Octave, J.N., Laduron, P.M. Biochem. Pharmacol. (1991) [Pubmed]
  25. Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons. Yamada, M., Bolden-Watson, C., Watson, M.A., Cho, T., Coleman, N.J., Yamada, M., Richelson, E. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  26. Functional neuroanatomy of the ventral striopallidal GABA pathway. New sites of intervention in the treatment of schizophrenia. O'Connor, W.T. J. Neurosci. Methods (2001) [Pubmed]
  27. Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs. Binder, E.B., Kinkead, B., Owens, M.J., Nemeroff, C.B. Neuropsychopharmacology (2004) [Pubmed]
  28. Constitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix seven. Barroso, S., Richard, F., Nicolas-Ethève, D., Kitabgi, P., Labbé-Jullié, C. Br. J. Pharmacol. (2002) [Pubmed]
  29. Neurotensin receptors in human neoplasms: high incidence in Ewing's sarcomas. Reubi, J.C., Waser, B., Schaer, J.C., Laissue, J.A. Int. J. Cancer (1999) [Pubmed]
  30. Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive. Buhler, A.V., Choi, J., Proudfit, H.K., Gebhart, G.F. Pain (2005) [Pubmed]
  31. Different subcellular localization of neurotensin-receptor and neurotensin-acceptor sites in the rat brain dopaminergic system. Schotte, A., Rostène, W., Laduron, P.M. J. Neurochem. (1988) [Pubmed]
 
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