Mediation by neurotensin-receptors of effects of neurotensin on self-stimulation of the medial prefrontal cortex.
1 Intracortical microinjections of neurotensin ( NT) selectively decreased intracranial self-stimulation (ICSS) of the medial prefrontal cortex in the rat. 2 To elucidate whether this effect is mediated by NT receptors or by the formation of NT-dopamine complexes, we investigated the effects on ICSS of intracortical microinjections of neurotensin (1-11), an NT fragment that forms extracellular complexes with dopamine but does not bind to NT receptors. 3 We also studied the effects of the peripheral administration of SR 48692, a selective antagonist of NT receptors, on the inhibition of ICSS produced by the intracortical administration of NT. 4 Unilateral microinjections of neurotensin (1-11) at doses of 10, 20 and 40 nmol into the medial prefrontal cortex did not change the basal ICSS rate of this area. 5 The intraperitoneal administration of SR 48692 at doses of 0.08 and 0.16 mg kg-1 30 min before microinjection of 10 nmol of NT into the medial prefrontal cortex, antagonized the inhibition of ICSS produced by the neuropeptide. 6 These results demonstrate that the inhibitory effect of NT on ICSS is mediated by NT receptors.[1]References
- Mediation by neurotensin-receptors of effects of neurotensin on self-stimulation of the medial prefrontal cortex. Fernández, R., Sabater, R., Sáez, J.A., Montes, R., Alba, F., Ferrer, J.M. Br. J. Pharmacol. (1996) [Pubmed]
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